Incidental Mutation 'R3160:Or11g24'
ID 258120
Institutional Source Beutler Lab
Gene Symbol Or11g24
Ensembl Gene ENSMUSG00000057903
Gene Name olfactory receptor family 11 subfamily G member 24
Synonyms GA_x6K02T2PMLR-6121675-6122604, MOR106-2, Olfr739
MMRRC Submission 040611-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R3160 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50661978-50662907 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50662488 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 171 (C171S)
Ref Sequence ENSEMBL: ENSMUSP00000150559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]
AlphaFold E9Q1P0
Predicted Effect probably damaging
Transcript: ENSMUST00000075261
AA Change: C171S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: C171S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.1e-53 PFAM
Pfam:7tm_1 43 292 1.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216949
AA Change: C171S

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Meta Mutation Damage Score 0.6311 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy9 A G 16: 4,129,452 (GRCm39) L715P probably damaging Het
Amer2 A G 14: 60,616,000 (GRCm39) D65G probably damaging Het
Btnl2 T C 17: 34,577,039 (GRCm39) W65R probably damaging Het
Camk1g T C 1: 193,042,115 (GRCm39) T45A possibly damaging Het
Ccdc181 T A 1: 164,107,865 (GRCm39) S183T probably damaging Het
Cep350 T C 1: 155,738,910 (GRCm39) H2311R probably benign Het
Copa T A 1: 171,918,800 (GRCm39) C127S probably damaging Het
Crbn T C 6: 106,767,827 (GRCm39) Q221R probably benign Het
Dapk2 T G 9: 66,161,893 (GRCm39) V267G probably damaging Het
Decr1 T A 4: 15,930,972 (GRCm39) D120V probably damaging Het
Dennd1c C T 17: 57,373,562 (GRCm39) G637D possibly damaging Het
Disp1 T C 1: 182,868,806 (GRCm39) K1205E probably benign Het
Dnajc13 G T 9: 104,097,097 (GRCm39) N510K possibly damaging Het
Hnrnpu T C 1: 178,158,690 (GRCm39) probably benign Het
Iqgap1 G A 7: 80,402,086 (GRCm39) A393V probably benign Het
Irak2 G T 6: 113,649,721 (GRCm39) A119S probably benign Het
Itgb2l A G 16: 96,238,589 (GRCm39) L70P probably damaging Het
Itsn1 C A 16: 91,649,932 (GRCm39) S202* probably null Het
Mill2 A C 7: 18,590,099 (GRCm39) E127A probably benign Het
Msh6 T C 17: 88,292,909 (GRCm39) Y555H probably damaging Het
Myo18b A C 5: 112,840,594 (GRCm39) S2400A probably damaging Het
Naa25 A G 5: 121,573,135 (GRCm39) probably null Het
Nop2 A G 6: 125,111,555 (GRCm39) N96S probably benign Het
Or13c7b T A 4: 43,820,544 (GRCm39) K272N probably benign Het
Or2z2 T C 11: 58,346,053 (GRCm39) T241A probably damaging Het
Or4c52 T G 2: 89,845,365 (GRCm39) Y30* probably null Het
Pde5a T A 3: 122,575,277 (GRCm39) L356* probably null Het
Prss59 A G 6: 40,903,003 (GRCm39) M123T probably benign Het
Ralgapa1 A T 12: 55,756,371 (GRCm39) N1075K probably damaging Het
Rps2 G T 17: 24,939,952 (GRCm39) A129S probably benign Het
Serinc2 A G 4: 130,154,528 (GRCm39) S175P probably benign Het
Socs5 A T 17: 87,442,146 (GRCm39) Q362L probably damaging Het
Srbd1 A T 17: 86,437,643 (GRCm39) D233E probably benign Het
Srgap3 A G 6: 112,706,619 (GRCm39) V826A probably benign Het
Tns2 A G 15: 102,021,771 (GRCm39) E1118G possibly damaging Het
Topaz1 T C 9: 122,578,446 (GRCm39) I452T probably benign Het
Tuba8 A G 6: 121,199,697 (GRCm39) D127G possibly damaging Het
Tulp4 A G 17: 6,248,983 (GRCm39) M1V probably null Het
Urb1 A G 16: 90,594,791 (GRCm39) L247P probably damaging Het
Usp32 A G 11: 84,916,362 (GRCm39) W861R probably damaging Het
Vmn1r48 G A 6: 90,013,360 (GRCm39) T155I probably benign Het
Vmn2r117 A G 17: 23,679,352 (GRCm39) L624P probably damaging Het
Vstm5 T G 9: 15,168,594 (GRCm39) S53A probably benign Het
Yeats2 T C 16: 20,012,395 (GRCm39) V531A probably damaging Het
Other mutations in Or11g24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Or11g24 APN 14 50,662,018 (GRCm39) missense possibly damaging 0.88
IGL02430:Or11g24 APN 14 50,662,608 (GRCm39) missense probably benign
IGL02603:Or11g24 APN 14 50,662,657 (GRCm39) missense probably damaging 1.00
IGL02959:Or11g24 APN 14 50,662,389 (GRCm39) missense possibly damaging 0.76
IGL03154:Or11g24 APN 14 50,662,080 (GRCm39) missense probably benign 0.00
R0455:Or11g24 UTSW 14 50,662,359 (GRCm39) missense possibly damaging 0.45
R1984:Or11g24 UTSW 14 50,662,848 (GRCm39) missense possibly damaging 0.93
R3161:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R3162:Or11g24 UTSW 14 50,662,488 (GRCm39) missense probably damaging 0.99
R4821:Or11g24 UTSW 14 50,662,206 (GRCm39) missense possibly damaging 0.96
R4880:Or11g24 UTSW 14 50,662,758 (GRCm39) missense possibly damaging 0.90
R5047:Or11g24 UTSW 14 50,662,696 (GRCm39) missense probably damaging 1.00
R5384:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5385:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5386:Or11g24 UTSW 14 50,662,846 (GRCm39) missense possibly damaging 0.77
R5640:Or11g24 UTSW 14 50,662,111 (GRCm39) missense probably benign 0.18
R5809:Or11g24 UTSW 14 50,662,905 (GRCm39) makesense probably null
R6035:Or11g24 UTSW 14 50,661,984 (GRCm39) missense probably benign
R6035:Or11g24 UTSW 14 50,661,984 (GRCm39) missense probably benign
R6229:Or11g24 UTSW 14 50,662,662 (GRCm39) missense probably benign 0.38
R6614:Or11g24 UTSW 14 50,662,546 (GRCm39) missense probably benign 0.00
R7308:Or11g24 UTSW 14 50,662,722 (GRCm39) missense possibly damaging 0.57
R7443:Or11g24 UTSW 14 50,662,507 (GRCm39) missense probably damaging 1.00
R7699:Or11g24 UTSW 14 50,662,792 (GRCm39) missense probably benign
R7700:Or11g24 UTSW 14 50,662,792 (GRCm39) missense probably benign
R7851:Or11g24 UTSW 14 50,662,827 (GRCm39) missense probably damaging 0.99
R8397:Or11g24 UTSW 14 50,662,137 (GRCm39) missense probably damaging 1.00
R8906:Or11g24 UTSW 14 50,662,291 (GRCm39) missense probably damaging 1.00
R9393:Or11g24 UTSW 14 50,662,255 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTCCTTGGGTTCTACAGAATGC -3'
(R):5'- ATCCGCAAGTGGAGAAAGCC -3'

Sequencing Primer
(F):5'- ACAGAATGCTTTTTCCTGGCAG -3'
(R):5'- GTCCATCTCTTGAAGGAACTCTGAAC -3'
Posted On 2015-01-23