Incidental Mutation 'R3161:Olfr1351'
ID258170
Institutional Source Beutler Lab
Gene Symbol Olfr1351
Ensembl Gene ENSMUSG00000063216
Gene Nameolfactory receptor 1351
SynonymsMOR139-4, GA_x6K02T2QGN0-2794907-2793948
MMRRC Submission 040612-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.134) question?
Stock #R3161 (G1)
Quality Score225
Status Validated
Chromosome10
Chromosomal Location79012472-79019645 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 79017604 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Asparagine at position 94 (T94N)
Ref Sequence ENSEMBL: ENSMUSP00000149241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]
Predicted Effect probably benign
Transcript: ENSMUST00000080730
AA Change: T94N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: T94N

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203906
AA Change: T94N
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: T94N

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216030
AA Change: T94N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Meta Mutation Damage Score 0.242 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik T C 5: 63,896,490 probably benign Het
1700066M21Rik T A 1: 57,383,075 N203K probably benign Het
1700125H20Rik A G 11: 85,173,284 S84G probably damaging Het
Adcy9 A G 16: 4,311,588 L715P probably damaging Het
Adgrl2 G A 3: 148,817,551 L1354F probably damaging Het
Amer2 A G 14: 60,378,551 D65G probably damaging Het
Aox2 G T 1: 58,304,438 V427L possibly damaging Het
Atad2b C A 12: 4,939,689 N133K possibly damaging Het
Bptf A T 11: 107,074,476 D1182E probably damaging Het
Camk1g T C 1: 193,359,807 T45A possibly damaging Het
Caps2 C A 10: 112,182,486 Y180* probably null Het
Cfap54 T A 10: 93,045,278 K349N probably damaging Het
Ciz1 A G 2: 32,370,063 D207G probably benign Het
Copa T A 1: 172,091,233 C127S probably damaging Het
Crabp2 A T 3: 87,952,177 K45* probably null Het
Daam1 C A 12: 71,947,098 T425K unknown Het
Dapk2 T G 9: 66,254,611 V267G probably damaging Het
Disp1 T C 1: 183,087,242 K1205E probably benign Het
Dlg4 G C 11: 70,017,225 R4T probably damaging Het
Fbf1 A G 11: 116,148,220 I743T probably damaging Het
Fen1 A G 19: 10,200,291 L263P probably damaging Het
G6pc2 A G 2: 69,220,112 N27S probably damaging Het
Garnl3 A T 2: 33,034,711 N246K probably damaging Het
Gm7337 A C 5: 87,851,557 noncoding transcript Het
Gpr152 A G 19: 4,142,714 T85A probably benign Het
Hnrnpu T C 1: 178,331,125 probably benign Het
Ighv1-81 C G 12: 115,920,329 E101Q probably benign Het
Ipo9 T C 1: 135,409,476 T174A probably benign Het
Myo9a C T 9: 59,832,315 probably benign Het
Nup155 G T 15: 8,148,383 R1083S possibly damaging Het
Olfr213 C T 6: 116,540,846 A131V probably damaging Het
Olfr262 T C 19: 12,241,496 H55R probably benign Het
Olfr739 T A 14: 50,425,031 C171S probably damaging Het
Phyh T A 2: 4,937,671 probably benign Het
Pkp4 G T 2: 59,308,105 R233M probably damaging Het
Plcb1 A T 2: 135,335,482 Q578L probably benign Het
Ppil3 A T 1: 58,434,414 N92K probably benign Het
Prokr1 C T 6: 87,588,431 R144H probably damaging Het
Psap T C 10: 60,277,753 L4P possibly damaging Het
Rai14 T C 15: 10,633,164 T47A possibly damaging Het
Rps2 G T 17: 24,720,978 A129S probably benign Het
Sult2a4 T C 7: 13,989,471 T40A probably benign Het
Tacr2 A G 10: 62,265,245 D378G probably benign Het
Topaz1 T C 9: 122,749,381 I452T probably benign Het
Ttn A G 2: 76,833,237 probably benign Het
Vmn2r115 T A 17: 23,357,024 M532K possibly damaging Het
Vmn2r117 A G 17: 23,460,378 L624P probably damaging Het
Vstm5 T G 9: 15,257,298 S53A probably benign Het
Wipf1 C T 2: 73,434,949 E437K probably damaging Het
Wls G T 3: 159,897,436 C162F probably damaging Het
Yeats2 T C 16: 20,193,645 V531A probably damaging Het
Zfp868 A G 8: 69,612,085 S200P probably benign Het
Other mutations in Olfr1351
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00913:Olfr1351 APN 10 79018251 missense probably benign 0.00
IGL01833:Olfr1351 APN 10 79017936 missense probably benign
IGL02141:Olfr1351 APN 10 79017721 missense probably damaging 1.00
IGL02178:Olfr1351 APN 10 79017720 missense possibly damaging 0.59
R1070:Olfr1351 UTSW 10 79017850 missense probably damaging 0.99
R1631:Olfr1351 UTSW 10 79017405 missense probably benign 0.00
R1646:Olfr1351 UTSW 10 79017506 nonsense probably null
R1781:Olfr1351 UTSW 10 79017325 start codon destroyed probably null 0.89
R2358:Olfr1351 UTSW 10 79018188 missense probably damaging 1.00
R3162:Olfr1351 UTSW 10 79017604 missense probably benign
R3162:Olfr1351 UTSW 10 79017604 missense probably benign
R5874:Olfr1351 UTSW 10 79017357 missense possibly damaging 0.95
R6382:Olfr1351 UTSW 10 79017517 missense probably damaging 1.00
R7108:Olfr1351 UTSW 10 79017649 nonsense probably null
R7567:Olfr1351 UTSW 10 79017545 missense probably benign 0.04
R7568:Olfr1351 UTSW 10 79017507 missense probably benign
Predicted Primers PCR Primer
(F):5'- GTGACTGTCACTGGAAACCTAC -3'
(R):5'- TGCAGAATGACAGCCGTAATG -3'

Sequencing Primer
(F):5'- TGGAAACCTACTCATCATCATGG -3'
(R):5'- CCGTAATGCCAAAAAGGTGTGTAAC -3'
Posted On2015-01-23