Incidental Mutation 'R3276:Nsun6'
ID 258197
Institutional Source Beutler Lab
Gene Symbol Nsun6
Ensembl Gene ENSMUSG00000026707
Gene Name NOL1/NOP2/Sun domain family member 6
Synonyms 4933414E04Rik, 4933403D21Rik, NOPD1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # R3276 (G1)
Quality Score 203
Status Validated
Chromosome 2
Chromosomal Location 14995131-15055069 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 15009404 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028034] [ENSMUST00000076435] [ENSMUST00000114715] [ENSMUST00000195749]
AlphaFold Q7TS68
Predicted Effect probably benign
Transcript: ENSMUST00000028034
SMART Domains Protein: ENSMUSP00000028034
Gene: ENSMUSG00000026707

DomainStartEndE-ValueType
PUA 112 203 1.96e-4 SMART
Pfam:FtsJ 216 397 1.4e-8 PFAM
Pfam:Methyltransf_31 232 423 1.3e-9 PFAM
Pfam:Methyltransf_18 234 373 1.4e-8 PFAM
Pfam:Methyltransf_26 235 374 2.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000076435
SMART Domains Protein: ENSMUSP00000075766
Gene: ENSMUSG00000026707

DomainStartEndE-ValueType
PUA 112 203 1.96e-4 SMART
Pfam:FtsJ 224 392 4.7e-9 PFAM
Pfam:Nol1_Nop2_Fmu 227 464 4.7e-48 PFAM
Pfam:Methyltransf_31 232 423 8.8e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114715
SMART Domains Protein: ENSMUSP00000110363
Gene: ENSMUSG00000026707

DomainStartEndE-ValueType
PUA 61 152 1.96e-4 SMART
Pfam:FtsJ 165 346 4.5e-9 PFAM
Pfam:Methyltransf_31 181 372 2.3e-10 PFAM
Pfam:Methyltransf_18 183 322 2.8e-9 PFAM
Pfam:Methyltransf_26 184 323 5.1e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000195749
SMART Domains Protein: ENSMUSP00000141924
Gene: ENSMUSG00000026707

DomainStartEndE-ValueType
PUA 112 203 1.96e-4 SMART
Pfam:FtsJ 216 397 1.4e-8 PFAM
Pfam:Methyltransf_31 232 423 1.3e-9 PFAM
Pfam:Methyltransf_18 234 373 1.4e-8 PFAM
Pfam:Methyltransf_26 235 374 2.9e-9 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 96% (47/49)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 C T 8: 86,506,866 (GRCm38) R1269H probably damaging Het
Ace A G 11: 105,976,702 (GRCm38) E164G probably null Het
Als2 A T 1: 59,170,008 (GRCm38) V1464E possibly damaging Het
Atox1 A G 11: 55,450,553 (GRCm38) L52P possibly damaging Het
Btnl10 A G 11: 58,922,390 (GRCm38) K282E probably benign Het
Cdkn3 T C 14: 46,771,477 (GRCm38) probably benign Het
Col16a1 A G 4: 130,057,999 (GRCm38) K72E probably damaging Het
Col6a5 G A 9: 105,911,107 (GRCm38) R1565* probably null Het
Col6a6 T C 9: 105,786,230 (GRCm38) H36R probably benign Het
Cyp4b1 T C 4: 115,625,850 (GRCm38) N415D possibly damaging Het
Dennd4a G T 9: 64,888,993 (GRCm38) R767L probably damaging Het
Dhcr24 T C 4: 106,561,239 (GRCm38) F25L probably benign Het
Dhrs3 A G 4: 144,923,940 (GRCm38) T219A probably benign Het
Dhx58 A G 11: 100,696,979 (GRCm38) F584S probably damaging Het
Dmbt1 A G 7: 131,088,071 (GRCm38) T715A probably benign Het
Eogt T A 6: 97,131,394 (GRCm38) I229F probably benign Het
Ern2 T C 7: 122,180,964 (GRCm38) T164A possibly damaging Het
Fam133b A T 5: 3,558,522 (GRCm38) N84I probably damaging Het
Fbxl21 T A 13: 56,537,122 (GRCm38) Y346* probably null Het
Fcgbp C A 7: 28,091,661 (GRCm38) H782Q probably damaging Het
Gm11492 T C 11: 87,567,244 (GRCm38) V148A possibly damaging Het
Gm5592 A G 7: 41,288,380 (GRCm38) E362G probably benign Het
Golga3 T C 5: 110,201,998 (GRCm38) probably benign Het
Gpatch2l A G 12: 86,244,315 (GRCm38) T91A possibly damaging Het
Hsp90aa1 C A 12: 110,695,681 (GRCm38) probably null Het
Hsp90aa1 T A 12: 110,695,680 (GRCm38) M1L possibly damaging Het
Itgad C A 7: 128,190,981 (GRCm38) H651N possibly damaging Het
Itgav A G 2: 83,776,542 (GRCm38) D409G probably damaging Het
Kcnt2 A G 1: 140,609,639 (GRCm38) N1119S probably benign Het
Klhl32 T C 4: 24,682,063 (GRCm38) I207V probably benign Het
Klk14 G A 7: 43,692,077 (GRCm38) C51Y probably damaging Het
Lhfpl5 T C 17: 28,579,946 (GRCm38) I143T possibly damaging Het
Lrrk1 T C 7: 66,305,521 (GRCm38) K431E possibly damaging Het
Mag C T 7: 30,901,648 (GRCm38) probably null Het
Maml3 A T 3: 51,856,930 (GRCm38) N204K possibly damaging Het
Mrpl19 T C 6: 81,964,066 (GRCm38) S115G probably damaging Het
Mthfd1l G C 10: 4,148,025 (GRCm38) G954A probably damaging Het
Mut A G 17: 40,958,872 (GRCm38) probably null Het
Myo19 A G 11: 84,892,175 (GRCm38) I172V probably benign Het
Naca T C 10: 128,040,661 (GRCm38) probably benign Het
Nfatc2 T C 2: 168,506,994 (GRCm38) N638D possibly damaging Het
Olfr1412 A G 1: 92,588,813 (GRCm38) N161S probably benign Het
Olfr584 C A 7: 103,085,750 (GRCm38) D72E probably damaging Het
Olfr913 T A 9: 38,594,643 (GRCm38) C141S probably damaging Het
Padi6 A G 4: 140,735,389 (GRCm38) L307P probably damaging Het
Pafah1b1 G A 11: 74,690,232 (GRCm38) S57F probably damaging Het
Prcd A G 11: 116,659,811 (GRCm38) E103G possibly damaging Het
Prkx A T X: 77,771,275 (GRCm38) F260I probably damaging Het
Rad54l2 A G 9: 106,753,943 (GRCm38) probably null Het
Ranbp1 T C 16: 18,247,429 (GRCm38) probably benign Het
Rb1cc1 T A 1: 6,249,366 (GRCm38) M1003K probably benign Het
Scap A T 9: 110,374,025 (GRCm38) M256L probably benign Het
Sema4c C T 1: 36,549,879 (GRCm38) R722H possibly damaging Het
Sgk1 C T 10: 21,996,601 (GRCm38) R171W probably damaging Het
Spata7 A G 12: 98,637,598 (GRCm38) N75D possibly damaging Het
Tmem120b T A 5: 123,114,104 (GRCm38) I146N probably damaging Het
Ttc23l A G 15: 10,547,232 (GRCm38) F99L possibly damaging Het
Ube3a T A 7: 59,276,519 (GRCm38) C348* probably null Het
Ubr4 T A 4: 139,421,855 (GRCm38) D1777E probably benign Het
Unc79 C A 12: 103,113,217 (GRCm38) D1880E probably damaging Het
Usp36 C T 11: 118,276,759 (GRCm38) probably null Het
Zswim9 T C 7: 13,277,270 (GRCm38) T51A possibly damaging Het
Other mutations in Nsun6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01123:Nsun6 APN 2 15,048,978 (GRCm38) missense possibly damaging 0.69
IGL02347:Nsun6 APN 2 15,030,020 (GRCm38) splice site probably benign
IGL03352:Nsun6 APN 2 14,996,346 (GRCm38) nonsense probably null
R0371:Nsun6 UTSW 2 15,030,087 (GRCm38) missense probably damaging 1.00
R0639:Nsun6 UTSW 2 14,996,336 (GRCm38) missense probably benign
R0737:Nsun6 UTSW 2 14,996,474 (GRCm38) missense probably damaging 1.00
R1076:Nsun6 UTSW 2 15,009,472 (GRCm38) missense probably benign 0.01
R1676:Nsun6 UTSW 2 15,047,213 (GRCm38) nonsense probably null
R1842:Nsun6 UTSW 2 15,009,477 (GRCm38) missense probably damaging 0.98
R1989:Nsun6 UTSW 2 15,038,184 (GRCm38) missense probably benign
R2091:Nsun6 UTSW 2 15,039,731 (GRCm38) critical splice donor site probably null
R2972:Nsun6 UTSW 2 15,038,072 (GRCm38) critical splice donor site probably null
R4386:Nsun6 UTSW 2 14,996,522 (GRCm38) missense probably benign 0.05
R4761:Nsun6 UTSW 2 15,030,061 (GRCm38) missense possibly damaging 0.88
R4782:Nsun6 UTSW 2 15,036,326 (GRCm38) missense possibly damaging 0.88
R6701:Nsun6 UTSW 2 15,036,302 (GRCm38) missense probably benign 0.00
R6890:Nsun6 UTSW 2 15,048,977 (GRCm38) missense probably damaging 1.00
R7555:Nsun6 UTSW 2 14,996,339 (GRCm38) missense possibly damaging 0.73
R7587:Nsun6 UTSW 2 15,039,825 (GRCm38) missense probably benign
R7880:Nsun6 UTSW 2 14,996,379 (GRCm38) missense probably damaging 0.99
R7888:Nsun6 UTSW 2 14,996,544 (GRCm38) missense probably benign 0.01
R8160:Nsun6 UTSW 2 15,009,408 (GRCm38) critical splice donor site probably null
R8458:Nsun6 UTSW 2 15,030,052 (GRCm38) missense probably benign
R8784:Nsun6 UTSW 2 14,996,495 (GRCm38) nonsense probably null
R9320:Nsun6 UTSW 2 15,042,237 (GRCm38) missense probably benign 0.01
R9643:Nsun6 UTSW 2 15,042,295 (GRCm38) missense probably benign
R9710:Nsun6 UTSW 2 14,998,198 (GRCm38) missense probably benign
Z1177:Nsun6 UTSW 2 15,039,820 (GRCm38) missense probably benign
Z1177:Nsun6 UTSW 2 15,030,103 (GRCm38) missense probably damaging 1.00
Z1192:Nsun6 UTSW 2 15,038,107 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAAGCATCCCAAATCCTTTTC -3'
(R):5'- GAAAGTCTTATTGCTCTGGTATGGC -3'

Sequencing Primer
(F):5'- CAAGGGCCATTCATGTTGTAGCAC -3'
(R):5'- TAAGCATTCTTAGCTTAGTCAAGCAC -3'
Posted On 2015-01-23