Incidental Mutation 'R3410:Vmn2r65'
| ID |
258461 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r65
|
| Ensembl Gene |
ENSMUSG00000066372 |
| Gene Name |
vomeronasal 2, receptor 65 |
| Synonyms |
ENSMUSG00000070600 |
| MMRRC Submission |
040628-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R3410 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84595896 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 263
(I263V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
| AlphaFold |
G3X931 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044583
AA Change: I263V
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: I263V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
|
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
|
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
100% (59/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adad2 |
T |
C |
8: 120,342,708 (GRCm39) |
V418A |
probably benign |
Het |
| Adamts16 |
T |
C |
13: 70,901,345 (GRCm39) |
T911A |
probably benign |
Het |
| Adgra1 |
T |
C |
7: 139,427,619 (GRCm39) |
F62S |
possibly damaging |
Het |
| Adgra3 |
A |
G |
5: 50,159,272 (GRCm39) |
V326A |
probably damaging |
Het |
| Adgrg6 |
A |
G |
10: 14,316,114 (GRCm39) |
F569S |
probably benign |
Het |
| Alcam |
T |
C |
16: 52,130,261 (GRCm39) |
T30A |
probably null |
Het |
| Arnt2 |
G |
A |
7: 83,924,655 (GRCm39) |
R391W |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,576,196 (GRCm39) |
V817A |
probably damaging |
Het |
| Atp13a4 |
G |
T |
16: 29,232,567 (GRCm39) |
T923K |
probably damaging |
Het |
| Atp5po |
C |
T |
16: 91,725,794 (GRCm39) |
R64H |
probably damaging |
Het |
| Ccdc185 |
T |
G |
1: 182,576,313 (GRCm39) |
Q125H |
possibly damaging |
Het |
| Ccdc88a |
T |
A |
11: 29,436,006 (GRCm39) |
C10S |
probably damaging |
Het |
| Cct2 |
T |
C |
10: 116,897,968 (GRCm39) |
N73S |
probably benign |
Het |
| Clock |
G |
A |
5: 76,377,401 (GRCm39) |
Q633* |
probably null |
Het |
| Col6a2 |
T |
C |
10: 76,439,193 (GRCm39) |
I826V |
probably benign |
Het |
| Cpsf1 |
G |
T |
15: 76,485,981 (GRCm39) |
Y396* |
probably null |
Het |
| Dnah1 |
A |
T |
14: 30,991,774 (GRCm39) |
M3076K |
possibly damaging |
Het |
| Dxo |
A |
G |
17: 35,057,825 (GRCm39) |
N177D |
probably damaging |
Het |
| Fbxw28 |
A |
T |
9: 109,167,472 (GRCm39) |
V95E |
possibly damaging |
Het |
| Galnt6 |
T |
C |
15: 100,597,018 (GRCm39) |
N383D |
probably damaging |
Het |
| Gpat2 |
G |
A |
2: 127,270,211 (GRCm39) |
V75M |
probably damaging |
Het |
| Grik5 |
T |
C |
7: 24,762,397 (GRCm39) |
D198G |
probably benign |
Het |
| Gsdmc4 |
A |
G |
15: 63,763,895 (GRCm39) |
S401P |
probably benign |
Het |
| Gspt1 |
A |
T |
16: 11,047,109 (GRCm39) |
D435E |
probably damaging |
Het |
| Hsf2 |
T |
C |
10: 57,381,378 (GRCm39) |
S266P |
probably damaging |
Het |
| Jade2 |
T |
C |
11: 51,708,050 (GRCm39) |
D721G |
probably benign |
Het |
| Klhl7 |
G |
T |
5: 24,343,319 (GRCm39) |
V212L |
probably damaging |
Het |
| Klra17 |
T |
A |
6: 129,851,809 (GRCm39) |
N21I |
probably damaging |
Het |
| L3mbtl3 |
T |
C |
10: 26,215,197 (GRCm39) |
N196S |
unknown |
Het |
| Lama3 |
G |
C |
18: 12,546,915 (GRCm39) |
|
probably null |
Het |
| Mcm5 |
T |
C |
8: 75,848,272 (GRCm39) |
M507T |
possibly damaging |
Het |
| Mycbp2 |
T |
C |
14: 103,372,553 (GRCm39) |
R814G |
probably damaging |
Het |
| Nlrp4b |
A |
G |
7: 10,449,456 (GRCm39) |
E186G |
probably damaging |
Het |
| Nlrp4c |
A |
G |
7: 6,095,569 (GRCm39) |
K816E |
possibly damaging |
Het |
| Nod1 |
G |
T |
6: 54,921,902 (GRCm39) |
R139S |
probably benign |
Het |
| Nudcd1 |
T |
C |
15: 44,284,207 (GRCm39) |
M60V |
probably benign |
Het |
| Or5b101 |
G |
C |
19: 13,005,411 (GRCm39) |
A94G |
probably benign |
Het |
| Or5p63 |
G |
A |
7: 107,811,490 (GRCm39) |
P82L |
possibly damaging |
Het |
| Or5p69 |
A |
T |
7: 107,967,551 (GRCm39) |
I285F |
possibly damaging |
Het |
| Or8g28 |
G |
T |
9: 39,169,897 (GRCm39) |
Q24K |
possibly damaging |
Het |
| Ovol2 |
A |
G |
2: 144,159,796 (GRCm39) |
S82P |
probably benign |
Het |
| Ppl |
T |
C |
16: 4,925,381 (GRCm39) |
E86G |
possibly damaging |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Ripk4 |
T |
C |
16: 97,545,157 (GRCm39) |
T497A |
probably benign |
Het |
| Scml4 |
A |
G |
10: 42,833,667 (GRCm39) |
Y327C |
probably damaging |
Het |
| Serpina3n |
A |
G |
12: 104,377,536 (GRCm39) |
E263G |
possibly damaging |
Het |
| Six4 |
A |
G |
12: 73,159,657 (GRCm39) |
F101S |
probably damaging |
Het |
| Sltm |
T |
G |
9: 70,493,240 (GRCm39) |
L728V |
probably damaging |
Het |
| Sptb |
T |
G |
12: 76,657,589 (GRCm39) |
K1311Q |
possibly damaging |
Het |
| Sycp1 |
T |
C |
3: 102,748,357 (GRCm39) |
K812E |
possibly damaging |
Het |
| Tenm4 |
T |
C |
7: 96,501,737 (GRCm39) |
Y1314H |
probably damaging |
Het |
| Tmem67 |
A |
T |
4: 12,073,952 (GRCm39) |
M288K |
probably benign |
Het |
| Toporsl |
T |
C |
4: 52,610,970 (GRCm39) |
S288P |
probably benign |
Het |
| Ttn |
A |
C |
2: 76,772,749 (GRCm39) |
N2415K |
possibly damaging |
Het |
| Vmn2r89 |
A |
T |
14: 51,693,628 (GRCm39) |
E326V |
probably damaging |
Het |
| Wdr81 |
A |
G |
11: 75,343,758 (GRCm39) |
I503T |
probably damaging |
Het |
|
| Other mutations in Vmn2r65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Vmn2r65
|
UTSW |
7 |
84,592,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6354:Vmn2r65
|
UTSW |
7 |
84,589,574 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Vmn2r65
|
UTSW |
7 |
84,613,198 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7021:Vmn2r65
|
UTSW |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7654:Vmn2r65
|
UTSW |
7 |
84,590,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r65
|
UTSW |
7 |
84,596,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGGTGCACTGTCTGGATG -3'
(R):5'- CACATTTCTGACCCTGGCCATG -3'
Sequencing Primer
(F):5'- GTCTGGATGAATTTCTTAAAACCAGG -3'
(R):5'- CCATGACGGCCTTAGTGG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation