Incidental Mutation 'R3410:Vmn2r89'
ID 258489
Institutional Source Beutler Lab
Gene Symbol Vmn2r89
Ensembl Gene ENSMUSG00000070448
Gene Name vomeronasal 2, receptor 89
Synonyms V2r10, V2r11
MMRRC Submission 040628-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R3410 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 51689419-51698750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 51693628 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 326 (E326V)
Ref Sequence ENSEMBL: ENSMUSP00000124256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159611] [ENSMUST00000159734] [ENSMUST00000161670] [ENSMUST00000162998]
AlphaFold O35199
Predicted Effect probably damaging
Transcript: ENSMUST00000159611
AA Change: E326V

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000124065
Gene: ENSMUSG00000070448
AA Change: E326V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 449 4.8e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000159734
AA Change: E326V

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000124256
Gene: ENSMUSG00000070448
AA Change: E326V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 420 1.1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161670
SMART Domains Protein: ENSMUSP00000124261
Gene: ENSMUSG00000070448

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162998
SMART Domains Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399

DomainStartEndE-ValueType
Pfam:Takusan 35 115 2.2e-25 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad2 T C 8: 120,342,708 (GRCm39) V418A probably benign Het
Adamts16 T C 13: 70,901,345 (GRCm39) T911A probably benign Het
Adgra1 T C 7: 139,427,619 (GRCm39) F62S possibly damaging Het
Adgra3 A G 5: 50,159,272 (GRCm39) V326A probably damaging Het
Adgrg6 A G 10: 14,316,114 (GRCm39) F569S probably benign Het
Alcam T C 16: 52,130,261 (GRCm39) T30A probably null Het
Arnt2 G A 7: 83,924,655 (GRCm39) R391W probably damaging Het
Ascc3 T C 10: 50,576,196 (GRCm39) V817A probably damaging Het
Atp13a4 G T 16: 29,232,567 (GRCm39) T923K probably damaging Het
Atp5po C T 16: 91,725,794 (GRCm39) R64H probably damaging Het
Ccdc185 T G 1: 182,576,313 (GRCm39) Q125H possibly damaging Het
Ccdc88a T A 11: 29,436,006 (GRCm39) C10S probably damaging Het
Cct2 T C 10: 116,897,968 (GRCm39) N73S probably benign Het
Clock G A 5: 76,377,401 (GRCm39) Q633* probably null Het
Col6a2 T C 10: 76,439,193 (GRCm39) I826V probably benign Het
Cpsf1 G T 15: 76,485,981 (GRCm39) Y396* probably null Het
Dnah1 A T 14: 30,991,774 (GRCm39) M3076K possibly damaging Het
Dxo A G 17: 35,057,825 (GRCm39) N177D probably damaging Het
Fbxw28 A T 9: 109,167,472 (GRCm39) V95E possibly damaging Het
Galnt6 T C 15: 100,597,018 (GRCm39) N383D probably damaging Het
Gpat2 G A 2: 127,270,211 (GRCm39) V75M probably damaging Het
Grik5 T C 7: 24,762,397 (GRCm39) D198G probably benign Het
Gsdmc4 A G 15: 63,763,895 (GRCm39) S401P probably benign Het
Gspt1 A T 16: 11,047,109 (GRCm39) D435E probably damaging Het
Hsf2 T C 10: 57,381,378 (GRCm39) S266P probably damaging Het
Jade2 T C 11: 51,708,050 (GRCm39) D721G probably benign Het
Klhl7 G T 5: 24,343,319 (GRCm39) V212L probably damaging Het
Klra17 T A 6: 129,851,809 (GRCm39) N21I probably damaging Het
L3mbtl3 T C 10: 26,215,197 (GRCm39) N196S unknown Het
Lama3 G C 18: 12,546,915 (GRCm39) probably null Het
Mcm5 T C 8: 75,848,272 (GRCm39) M507T possibly damaging Het
Mycbp2 T C 14: 103,372,553 (GRCm39) R814G probably damaging Het
Nlrp4b A G 7: 10,449,456 (GRCm39) E186G probably damaging Het
Nlrp4c A G 7: 6,095,569 (GRCm39) K816E possibly damaging Het
Nod1 G T 6: 54,921,902 (GRCm39) R139S probably benign Het
Nudcd1 T C 15: 44,284,207 (GRCm39) M60V probably benign Het
Or5b101 G C 19: 13,005,411 (GRCm39) A94G probably benign Het
Or5p63 G A 7: 107,811,490 (GRCm39) P82L possibly damaging Het
Or5p69 A T 7: 107,967,551 (GRCm39) I285F possibly damaging Het
Or8g28 G T 9: 39,169,897 (GRCm39) Q24K possibly damaging Het
Ovol2 A G 2: 144,159,796 (GRCm39) S82P probably benign Het
Ppl T C 16: 4,925,381 (GRCm39) E86G possibly damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ripk4 T C 16: 97,545,157 (GRCm39) T497A probably benign Het
Scml4 A G 10: 42,833,667 (GRCm39) Y327C probably damaging Het
Serpina3n A G 12: 104,377,536 (GRCm39) E263G possibly damaging Het
Six4 A G 12: 73,159,657 (GRCm39) F101S probably damaging Het
Sltm T G 9: 70,493,240 (GRCm39) L728V probably damaging Het
Sptb T G 12: 76,657,589 (GRCm39) K1311Q possibly damaging Het
Sycp1 T C 3: 102,748,357 (GRCm39) K812E possibly damaging Het
Tenm4 T C 7: 96,501,737 (GRCm39) Y1314H probably damaging Het
Tmem67 A T 4: 12,073,952 (GRCm39) M288K probably benign Het
Toporsl T C 4: 52,610,970 (GRCm39) S288P probably benign Het
Ttn A C 2: 76,772,749 (GRCm39) N2415K possibly damaging Het
Vmn2r65 T C 7: 84,595,896 (GRCm39) I263V probably benign Het
Wdr81 A G 11: 75,343,758 (GRCm39) I503T probably damaging Het
Other mutations in Vmn2r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Vmn2r89 APN 14 51,692,422 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r89 APN 14 51,694,950 (GRCm39) missense probably benign
IGL00990:Vmn2r89 APN 14 51,693,428 (GRCm39) missense probably benign 0.14
IGL01991:Vmn2r89 APN 14 51,689,676 (GRCm39) missense probably benign 0.00
IGL03073:Vmn2r89 APN 14 51,693,528 (GRCm39) missense possibly damaging 0.95
IGL03085:Vmn2r89 APN 14 51,689,615 (GRCm39) missense probably damaging 0.99
IGL03278:Vmn2r89 APN 14 51,692,557 (GRCm39) missense probably damaging 0.99
R0115:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0127:Vmn2r89 UTSW 14 51,693,160 (GRCm39) missense probably damaging 0.98
R0391:Vmn2r89 UTSW 14 51,693,435 (GRCm39) missense probably damaging 0.99
R0481:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0538:Vmn2r89 UTSW 14 51,695,048 (GRCm39) splice site probably null
R1210:Vmn2r89 UTSW 14 51,692,427 (GRCm39) missense probably benign 0.01
R1332:Vmn2r89 UTSW 14 51,692,559 (GRCm39) missense probably benign 0.00
R1660:Vmn2r89 UTSW 14 51,693,693 (GRCm39) missense possibly damaging 0.48
R1959:Vmn2r89 UTSW 14 51,694,897 (GRCm39) missense probably benign 0.22
R2876:Vmn2r89 UTSW 14 51,692,541 (GRCm39) missense possibly damaging 0.47
R4026:Vmn2r89 UTSW 14 51,689,500 (GRCm39) start codon destroyed probably null 1.00
R4398:Vmn2r89 UTSW 14 51,689,551 (GRCm39) missense probably damaging 1.00
R4700:Vmn2r89 UTSW 14 51,694,942 (GRCm39) missense probably damaging 1.00
R4714:Vmn2r89 UTSW 14 51,689,688 (GRCm39) missense probably damaging 0.97
R5162:Vmn2r89 UTSW 14 51,693,620 (GRCm39) missense possibly damaging 0.88
R5294:Vmn2r89 UTSW 14 51,692,570 (GRCm39) missense probably benign 0.00
R5811:Vmn2r89 UTSW 14 51,693,565 (GRCm39) missense probably benign 0.12
R6087:Vmn2r89 UTSW 14 51,695,033 (GRCm39) splice site probably null
R6229:Vmn2r89 UTSW 14 51,693,178 (GRCm39) missense probably benign 0.05
R6246:Vmn2r89 UTSW 14 51,693,503 (GRCm39) missense probably damaging 1.00
R6572:Vmn2r89 UTSW 14 51,693,450 (GRCm39) missense probably damaging 1.00
R7351:Vmn2r89 UTSW 14 51,693,739 (GRCm39) missense probably benign 0.30
R7683:Vmn2r89 UTSW 14 51,692,651 (GRCm39) missense probably benign
R7974:Vmn2r89 UTSW 14 51,693,459 (GRCm39) missense probably damaging 1.00
R8047:Vmn2r89 UTSW 14 51,692,549 (GRCm39) missense probably benign 0.05
R8093:Vmn2r89 UTSW 14 51,693,699 (GRCm39) missense probably benign 0.00
R8348:Vmn2r89 UTSW 14 51,692,548 (GRCm39) missense possibly damaging 0.90
R8723:Vmn2r89 UTSW 14 51,693,910 (GRCm39) missense probably benign
R8737:Vmn2r89 UTSW 14 51,693,722 (GRCm39) missense probably damaging 1.00
R8859:Vmn2r89 UTSW 14 51,693,170 (GRCm39) missense probably benign
R9183:Vmn2r89 UTSW 14 51,692,501 (GRCm39) missense probably benign 0.01
R9197:Vmn2r89 UTSW 14 51,693,596 (GRCm39) missense possibly damaging 0.70
R9377:Vmn2r89 UTSW 14 51,692,601 (GRCm39) missense probably benign 0.02
R9395:Vmn2r89 UTSW 14 51,693,783 (GRCm39) missense probably damaging 1.00
R9452:Vmn2r89 UTSW 14 51,693,288 (GRCm39) missense probably damaging 0.99
R9457:Vmn2r89 UTSW 14 51,693,469 (GRCm39) missense probably damaging 0.99
R9678:Vmn2r89 UTSW 14 51,693,511 (GRCm39) missense probably benign 0.09
X0019:Vmn2r89 UTSW 14 51,693,872 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TGCAGATATACATGACAAGGGCTAC -3'
(R):5'- GCAGTGCTGTCCATTCCAATG -3'

Sequencing Primer
(F):5'- ATGACATCTTCAGCAAAGGTTG -3'
(R):5'- GCTGTCCATTCCAATGTGTTG -3'
Posted On 2015-01-23