|Institutional Source||Beutler Lab|
|Gene Name||neuromedin U receptor 2|
|Is this an essential gene?||Probably non essential (E-score: 0.145)|
|Stock #||R3701 (G1)|
|Chromosomal Location||56024987-56041010 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 56040777 bp|
|Amino Acid Change||Leucine to Proline at position 36 (L36P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000044718 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000037682]|
|Predicted Effect||probably damaging
AA Change: L36P
PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
AA Change: L36P
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.6467|
|Coding Region Coverage||
|Validation Efficiency||97% (37/38)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for one knock-out allele exhibit increased chemical and thermal nociception thresholds, insensitivity to treatment with Nmu or Nms, and altered weight gain following a fast or when fed a high-fat diet that can be sex-dependent. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nmur2||
(F):5'- CTTGAAGTAGCATCCCACCG -3'
(R):5'- TCAGCTTGAGACAGAGCCTC -3'
(F):5'- GGATAATTGTGCCACAACTCG -3'
(R):5'- TTGAGACAGAGCCTCAAGAGC -3'