Incidental Mutation 'R3705:Or5w22'
ID 258687
Institutional Source Beutler Lab
Gene Symbol Or5w22
Ensembl Gene ENSMUSG00000061520
Gene Name olfactory receptor family 5 subfamily W member 22
Synonyms Olfr4-2, V5, GA_x6K02T2Q125-49033418-49034341, MOR177-5, Olfr153
MMRRC Submission 040698-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R3705 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87362379-87363302 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87362412 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 12 (I12V)
Ref Sequence ENSEMBL: ENSMUSP00000149859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077471] [ENSMUST00000217113]
AlphaFold Q7TR48
Predicted Effect probably benign
Transcript: ENSMUST00000077471
AA Change: I12V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000076681
Gene: ENSMUSG00000075151
AA Change: I12V

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 6e-48 PFAM
Pfam:7tm_1 40 289 2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217113
AA Change: I12V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Abca12 T C 1: 71,324,864 (GRCm39) D1538G probably damaging Het
Asap3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGAGGAGGA 4: 135,968,552 (GRCm39) probably benign Het
Bcap29 T C 12: 31,667,151 (GRCm39) H170R probably benign Het
Bltp1 T A 3: 37,041,730 (GRCm39) C2703S probably damaging Het
Brwd3 A G X: 107,804,021 (GRCm39) probably benign Het
Capn1 T C 19: 6,057,401 (GRCm39) E349G probably damaging Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Csf3r A G 4: 125,926,078 (GRCm39) D221G possibly damaging Het
Cubn T A 2: 13,355,754 (GRCm39) H1826L probably damaging Het
Dnajc19 A G 3: 34,134,378 (GRCm39) probably null Het
Dync1h1 G A 12: 110,607,020 (GRCm39) V2566I possibly damaging Het
Ehd1 A G 19: 6,348,330 (GRCm39) D436G Het
Fam133b T C 5: 3,611,034 (GRCm39) probably benign Het
Fam43b G C 4: 138,122,409 (GRCm39) R304G probably benign Het
Gpnmb T A 6: 49,028,799 (GRCm39) I439N possibly damaging Het
Grm1 G A 10: 10,658,473 (GRCm39) T339I possibly damaging Het
Gtpbp3 T G 8: 71,944,779 (GRCm39) S345A probably benign Het
Hdac4 A G 1: 91,862,416 (GRCm39) probably benign Het
Hfm1 A G 5: 107,040,705 (GRCm39) probably benign Het
Ift172 A G 5: 31,418,781 (GRCm39) probably null Het
Igfn1 T C 1: 135,896,147 (GRCm39) N1473S probably benign Het
Jak3 A G 8: 72,134,166 (GRCm39) K423E probably damaging Het
Kifc3 G A 8: 95,830,656 (GRCm39) probably benign Het
Lrrc8d T C 5: 105,961,341 (GRCm39) S584P probably damaging Het
Nipal4 T C 11: 46,052,678 (GRCm39) probably benign Het
Nisch A G 14: 30,898,702 (GRCm39) probably benign Het
Nmur2 T C 11: 55,931,300 (GRCm39) Y137C probably damaging Het
Nod2 T C 8: 89,379,948 (GRCm39) S150P probably benign Het
Pdgfc T C 3: 81,111,751 (GRCm39) probably null Het
Phldb1 G T 9: 44,605,691 (GRCm39) H1323N probably damaging Het
Ppp1r14c A G 10: 3,373,524 (GRCm39) I112V possibly damaging Het
Pramel26 T C 4: 143,538,345 (GRCm39) T209A probably benign Het
Rcc1l A T 5: 134,183,030 (GRCm39) V414E probably damaging Het
Riok3 A G 18: 12,282,011 (GRCm39) M327V probably benign Het
Sf3b4 T C 3: 96,083,944 (GRCm39) probably benign Het
Spag6 A G 2: 18,715,368 (GRCm39) Y49C probably damaging Het
Syngap1 T C 17: 27,178,994 (GRCm39) S495P probably damaging Het
Tedc2 A G 17: 24,435,361 (GRCm39) S343P probably benign Het
Tenm2 T A 11: 35,959,153 (GRCm39) D1132V probably damaging Het
Tmem63a G A 1: 180,790,679 (GRCm39) D446N possibly damaging Het
Top1 G A 2: 160,544,744 (GRCm39) probably null Het
Tox3 G T 8: 90,975,533 (GRCm39) T366K possibly damaging Het
Tph2 G A 10: 114,955,798 (GRCm39) Q332* probably null Het
Zfr2 T G 10: 81,081,913 (GRCm39) V493G probably benign Het
Other mutations in Or5w22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01320:Or5w22 APN 2 87,362,629 (GRCm39) missense probably benign 0.01
IGL02102:Or5w22 APN 2 87,362,805 (GRCm39) missense probably benign
IGL02604:Or5w22 APN 2 87,362,949 (GRCm39) missense probably damaging 0.98
IGL02695:Or5w22 APN 2 87,362,461 (GRCm39) missense probably benign 0.00
IGL02961:Or5w22 APN 2 87,363,028 (GRCm39) missense probably damaging 0.98
PIT4696001:Or5w22 UTSW 2 87,363,124 (GRCm39) missense probably damaging 1.00
R0727:Or5w22 UTSW 2 87,363,245 (GRCm39) nonsense probably null
R1534:Or5w22 UTSW 2 87,363,016 (GRCm39) missense probably damaging 0.99
R1699:Or5w22 UTSW 2 87,362,427 (GRCm39) missense probably benign 0.07
R1885:Or5w22 UTSW 2 87,363,168 (GRCm39) missense probably damaging 0.99
R5664:Or5w22 UTSW 2 87,363,178 (GRCm39) missense probably benign 0.35
R6492:Or5w22 UTSW 2 87,363,085 (GRCm39) missense possibly damaging 0.66
R6808:Or5w22 UTSW 2 87,363,285 (GRCm39) missense probably benign
R7432:Or5w22 UTSW 2 87,362,784 (GRCm39) missense probably damaging 1.00
R7477:Or5w22 UTSW 2 87,362,431 (GRCm39) missense probably benign 0.00
R8014:Or5w22 UTSW 2 87,362,508 (GRCm39) missense probably benign 0.13
R8345:Or5w22 UTSW 2 87,362,691 (GRCm39) missense probably benign 0.01
R8887:Or5w22 UTSW 2 87,363,187 (GRCm39) missense possibly damaging 0.95
R8971:Or5w22 UTSW 2 87,362,580 (GRCm39) missense probably benign 0.19
R9311:Or5w22 UTSW 2 87,362,358 (GRCm39) start gained probably benign
R9690:Or5w22 UTSW 2 87,362,759 (GRCm39) missense probably benign 0.03
X0028:Or5w22 UTSW 2 87,362,383 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGACTGTCCATCCCAGATATTG -3'
(R):5'- TCACAGAAAGACAAGTGGCTC -3'

Sequencing Primer
(F):5'- GTCCATCCCAGATATTGGTCATTTTG -3'
(R):5'- CTCAGGAAAAAGTACATGGGTGTGTG -3'
Posted On 2015-01-23