Incidental Mutation 'R3705:Dnajc19'
ID258689
Institutional Source Beutler Lab
Gene Symbol Dnajc19
Ensembl Gene ENSMUSG00000027679
Gene NameDnaJ heat shock protein family (Hsp40) member C19
Synonyms1810055D05Rik
MMRRC Submission 040698-MU
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #R3705 (G1)
Quality Score225
Status Validated
Chromosome3
Chromosomal Location34056020-34081321 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 34080229 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113484 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011029] [ENSMUST00000108195] [ENSMUST00000117223] [ENSMUST00000120805]
Predicted Effect probably null
Transcript: ENSMUST00000011029
SMART Domains Protein: ENSMUSP00000011029
Gene: ENSMUSG00000027679

DomainStartEndE-ValueType
transmembrane domain 4 23 N/A INTRINSIC
DnaJ 61 101 1.31e-1 SMART
low complexity region 106 124 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000108195
SMART Domains Protein: ENSMUSP00000103830
Gene: ENSMUSG00000027679

DomainStartEndE-ValueType
transmembrane domain 4 23 N/A INTRINSIC
DnaJ 61 115 1.05e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000117223
SMART Domains Protein: ENSMUSP00000113484
Gene: ENSMUSG00000027679

DomainStartEndE-ValueType
transmembrane domain 4 23 N/A INTRINSIC
DnaJ 61 109 2.01e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120805
SMART Domains Protein: ENSMUSP00000113514
Gene: ENSMUSG00000027679

DomainStartEndE-ValueType
DnaJ 55 109 1.05e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197014
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197111
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T A 3: 36,987,581 C2703S probably damaging Het
9930111J21Rik1 T C 11: 48,947,976 T595A possibly damaging Het
Abca12 T C 1: 71,285,705 D1538G probably damaging Het
Asap3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGAGGAGGA 4: 136,241,241 probably benign Het
Bcap29 T C 12: 31,617,152 H170R probably benign Het
Brwd3 A G X: 108,760,415 probably benign Het
Capn1 T C 19: 6,007,371 E349G probably damaging Het
Cers3 G T 7: 66,786,075 A261S probably benign Het
Csf3r A G 4: 126,032,285 D221G possibly damaging Het
Cubn T A 2: 13,350,943 H1826L probably damaging Het
Dync1h1 G A 12: 110,640,586 V2566I possibly damaging Het
Ehd1 A G 19: 6,298,300 D436G probably benign Het
Fam133b T C 5: 3,561,034 probably benign Het
Fam43b G C 4: 138,395,098 R304G probably benign Het
Gm13084 T C 4: 143,811,775 T209A probably benign Het
Gpnmb T A 6: 49,051,865 I439N possibly damaging Het
Grm1 G A 10: 10,782,729 T339I possibly damaging Het
Gtpbp3 T G 8: 71,492,135 S345A probably benign Het
Hdac4 A G 1: 91,934,694 probably benign Het
Hfm1 A G 5: 106,892,839 probably benign Het
Ift172 A G 5: 31,261,437 probably null Het
Igfn1 T C 1: 135,968,409 N1473S probably benign Het
Jak3 A G 8: 71,681,522 K423E probably damaging Het
Kifc3 G A 8: 95,104,028 probably benign Het
Lrrc8d T C 5: 105,813,475 S584P probably damaging Het
Nipal4 T C 11: 46,161,851 probably benign Het
Nisch A G 14: 31,176,745 probably benign Het
Nmur2 T C 11: 56,040,474 Y137C probably damaging Het
Nod2 T C 8: 88,653,320 S150P probably benign Het
Olfr153 A G 2: 87,532,068 I12V probably benign Het
Pdgfc T C 3: 81,204,444 probably null Het
Phldb1 G T 9: 44,694,394 H1323N probably damaging Het
Ppp1r14c A G 10: 3,423,524 I112V possibly damaging Het
Rcc1l A T 5: 134,154,191 V414E probably damaging Het
Riok3 A G 18: 12,148,954 M327V probably benign Het
Sf3b4 T C 3: 96,176,628 probably benign Het
Spag6 A G 2: 18,710,557 Y49C probably damaging Het
Syngap1 T C 17: 26,960,020 S495P probably damaging Het
Tedc2 A G 17: 24,216,387 S343P probably benign Het
Tenm2 T A 11: 36,068,326 D1132V probably damaging Het
Tmem63a G A 1: 180,963,114 D446N possibly damaging Het
Top1 G A 2: 160,702,824 probably null Het
Tox3 G T 8: 90,248,905 T366K possibly damaging Het
Tph2 G A 10: 115,119,893 Q332* probably null Het
Zfr2 T G 10: 81,246,079 V493G probably benign Het
Other mutations in Dnajc19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02071:Dnajc19 APN 3 34078765 missense possibly damaging 0.81
FR4976:Dnajc19 UTSW 3 34057994 frame shift probably null
IGL03134:Dnajc19 UTSW 3 34078735 intron probably benign
R1344:Dnajc19 UTSW 3 34058012 missense probably damaging 0.97
R1446:Dnajc19 UTSW 3 34057979 missense probably benign 0.00
R3703:Dnajc19 UTSW 3 34080229 critical splice donor site probably null
R5234:Dnajc19 UTSW 3 34057959 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCAGGCTTCAAATACAGGCAAG -3'
(R):5'- AGGCACCTTACCAGCATGAG -3'

Sequencing Primer
(F):5'- CAAGTTAGTTAGCAAGAAGGTTCAC -3'
(R):5'- GCATGAGACACACACTAGGTTC -3'
Posted On2015-01-23