Mutagenetix > Incidental Mutation

Incidental Mutation 'R3705:Dync1h1'

258721

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

9930018I23Rik, Dnchc1, dynein heavy chain, retrograde transport, Swl, MAP1C, Loa, Dnec1

MMRRC Submission

040698-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R3705 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

110601452-110666945 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 110640586 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 2566 (V2566I)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000018851
AA Change: V2566I

PolyPhen 2 Score 0.796 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: V2566I

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000172218

Meta Mutation Damage Score

0.1317

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

100% (46/46)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	A	3: 36,987,581	C2703S	probably damaging	Het
9930111J21Rik1	T	C	11: 48,947,976	T595A	possibly damaging	Het
Abca12	T	C	1: 71,285,705	D1538G	probably damaging	Het
Asap3	TGAGGAGGAGGAGGAGGA	TGAGGAGGAGGAGGAGGAGGA	4: 136,241,241		probably benign	Het
Bcap29	T	C	12: 31,617,152	H170R	probably benign	Het
Brwd3	A	G	X: 108,760,415		probably benign	Het
Capn1	T	C	19: 6,007,371	E349G	probably damaging	Het
Cers3	G	T	7: 66,786,075	A261S	probably benign	Het
Csf3r	A	G	4: 126,032,285	D221G	possibly damaging	Het
Cubn	T	A	2: 13,350,943	H1826L	probably damaging	Het
Dnajc19	A	G	3: 34,080,229		probably null	Het
Ehd1	A	G	19: 6,298,300	D436G		Het
Fam133b	T	C	5: 3,561,034		probably benign	Het
Fam43b	G	C	4: 138,395,098	R304G	probably benign	Het
Gm13084	T	C	4: 143,811,775	T209A	probably benign	Het
Gpnmb	T	A	6: 49,051,865	I439N	possibly damaging	Het
Grm1	G	A	10: 10,782,729	T339I	possibly damaging	Het
Gtpbp3	T	G	8: 71,492,135	S345A	probably benign	Het
Hdac4	A	G	1: 91,934,694		probably benign	Het
Hfm1	A	G	5: 106,892,839		probably benign	Het
Ift172	A	G	5: 31,261,437		probably null	Het
Igfn1	T	C	1: 135,968,409	N1473S	probably benign	Het
Jak3	A	G	8: 71,681,522	K423E	probably damaging	Het
Kifc3	G	A	8: 95,104,028		probably benign	Het
Lrrc8d	T	C	5: 105,813,475	S584P	probably damaging	Het
Nipal4	T	C	11: 46,161,851		probably benign	Het
Nisch	A	G	14: 31,176,745		probably benign	Het
Nmur2	T	C	11: 56,040,474	Y137C	probably damaging	Het
Nod2	T	C	8: 88,653,320	S150P	probably benign	Het
Olfr153	A	G	2: 87,532,068	I12V	probably benign	Het
Pdgfc	T	C	3: 81,204,444		probably null	Het
Phldb1	G	T	9: 44,694,394	H1323N	probably damaging	Het
Ppp1r14c	A	G	10: 3,423,524	I112V	possibly damaging	Het
Rcc1l	A	T	5: 134,154,191	V414E	probably damaging	Het
Riok3	A	G	18: 12,148,954	M327V	probably benign	Het
Sf3b4	T	C	3: 96,176,628		probably benign	Het
Spag6	A	G	2: 18,710,557	Y49C	probably damaging	Het
Syngap1	T	C	17: 26,960,020	S495P	probably damaging	Het
Tedc2	A	G	17: 24,216,387	S343P	probably benign	Het
Tenm2	T	A	11: 36,068,326	D1132V	probably damaging	Het
Tmem63a	G	A	1: 180,963,114	D446N	possibly damaging	Het
Top1	G	A	2: 160,702,824		probably null	Het
Tox3	G	T	8: 90,248,905	T366K	possibly damaging	Het
Tph2	G	A	10: 115,119,893	Q332*	probably null	Het
Zfr2	T	G	10: 81,246,079	V493G	probably benign	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,649,104 (GRCm38)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,614,107 (GRCm38)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,625,607 (GRCm38)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,626,865 (GRCm38)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,616,692 (GRCm38)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,638,851 (GRCm38)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,658,128 (GRCm38)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,614,940 (GRCm38)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,658,930 (GRCm38)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,652,196 (GRCm38)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,637,124 (GRCm38)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,662,559 (GRCm38)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,663,002 (GRCm38)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,640,888 (GRCm38)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,640,210 (GRCm38)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,659,232 (GRCm38)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,659,272 (GRCm38)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,657,893 (GRCm38)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,666,555 (GRCm38)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,628,734 (GRCm38)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,619,210 (GRCm38)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
Gesund	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
gymnast	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
Lissom	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
Strong	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
waters	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,649,104 (GRCm38)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,616,807 (GRCm38)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,636,446 (GRCm38)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,618,674 (GRCm38)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,631,692 (GRCm38)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,632,788 (GRCm38)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,616,496 (GRCm38)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,651,747 (GRCm38)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,657,192 (GRCm38)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,629,284 (GRCm38)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,612,411 (GRCm38)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,665,213 (GRCm38)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,665,959 (GRCm38)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,649,264 (GRCm38)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,656,357 (GRCm38)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,665,662 (GRCm38)	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110,626,992 (GRCm38)	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,632,928 (GRCm38)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,662,900 (GRCm38)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,662,625 (GRCm38)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,624,636 (GRCm38)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,646,304 (GRCm38)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,662,629 (GRCm38)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,625,732 (GRCm38)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,666,423 (GRCm38)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,614,592 (GRCm38)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,649,588 (GRCm38)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,629,986 (GRCm38)	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110,640,882 (GRCm38)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,656,631 (GRCm38)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,641,220 (GRCm38)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,643,247 (GRCm38)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,616,891 (GRCm38)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,641,026 (GRCm38)	critical splice donor site	probably null
R3708:Dync1h1	UTSW	12	110,643,129 (GRCm38)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,629,058 (GRCm38)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,665,965 (GRCm38)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,643,190 (GRCm38)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,618,049 (GRCm38)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,632,899 (GRCm38)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,657,139 (GRCm38)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,649,483 (GRCm38)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,638,844 (GRCm38)	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110,628,767 (GRCm38)	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110,662,541 (GRCm38)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,655,528 (GRCm38)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,661,196 (GRCm38)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,639,801 (GRCm38)	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,662,855 (GRCm38)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,618,010 (GRCm38)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,626,892 (GRCm38)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,630,535 (GRCm38)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,640,907 (GRCm38)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,617,932 (GRCm38)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,629,680 (GRCm38)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,628,830 (GRCm38)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,615,068 (GRCm38)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,632,665 (GRCm38)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,660,950 (GRCm38)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,641,141 (GRCm38)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,665,988 (GRCm38)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,629,062 (GRCm38)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,646,273 (GRCm38)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,614,220 (GRCm38)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,632,778 (GRCm38)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,620,414 (GRCm38)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,628,006 (GRCm38)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,617,993 (GRCm38)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,646,205 (GRCm38)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,616,737 (GRCm38)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,649,848 (GRCm38)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,658,547 (GRCm38)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,652,180 (GRCm38)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,624,561 (GRCm38)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,638,901 (GRCm38)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,666,087 (GRCm38)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,657,078 (GRCm38)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,601,739 (GRCm38)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,617,762 (GRCm38)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,664,749 (GRCm38)	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110,665,162 (GRCm38)	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110,635,642 (GRCm38)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,624,602 (GRCm38)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,634,220 (GRCm38)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,665,675 (GRCm38)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,651,577 (GRCm38)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,614,107 (GRCm38)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,630,625 (GRCm38)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,660,893 (GRCm38)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,618,646 (GRCm38)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,665,766 (GRCm38)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,655,459 (GRCm38)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,643,156 (GRCm38)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,616,457 (GRCm38)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,628,734 (GRCm38)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,616,360 (GRCm38)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,636,474 (GRCm38)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,665,792 (GRCm38)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,618,142 (GRCm38)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,616,743 (GRCm38)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,640,584 (GRCm38)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,614,580 (GRCm38)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,616,827 (GRCm38)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,616,738 (GRCm38)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,642,043 (GRCm38)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,658,168 (GRCm38)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,618,037 (GRCm38)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,620,371 (GRCm38)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,639,963 (GRCm38)	missense	probably benign
R9036:Dync1h1	UTSW	12	110,639,752 (GRCm38)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,656,272 (GRCm38)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,658,589 (GRCm38)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,635,503 (GRCm38)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,658,703 (GRCm38)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,658,371 (GRCm38)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,649,099 (GRCm38)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,640,928 (GRCm38)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,629,917 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,658,517 (GRCm38)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,641,177 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,637,554 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GATGAGCTTGTCCTGCCTGTAC -3'
(R):5'- TGTTCAAGCCCACACTTCAC -3'

Sequencing Primer
(F):5'- CCTGCCTGTACTTTGGAGATTTAAAC -3'
(R):5'- ACCCCAAAGCTCTTGTTTATGC -3'

Posted On

2015-01-23