|Institutional Source||Beutler Lab|
|Gene Name||guanine nucleotide binding protein (G protein), gamma 11|
|Is this an essential gene?||Probably non essential (E-score: 0.130)|
|Stock #||R3718 (G1)|
|Chromosomal Location||4003904-4008445 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 4008078 bp|
|Amino Acid Change||Arginine to Histidine at position 47 (R47H)|
|Ref Sequence||ENSEMBL: ENSMUSP00000031670 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031670]|
|Predicted Effect||probably benign
AA Change: R47H
PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
AA Change: R47H
|Meta Mutation Damage Score||0.0581|
|Coding Region Coverage||
|Validation Efficiency||97% (36/37)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gng11||
(F):5'- CGCGTCTTAGAGAGTAAGGAAATC -3'
(R):5'- ATTCACACCCCAACTGCTTGG -3'
(F):5'- TCTTAGAGAGTAAGGAAATCATGGG -3'
(R):5'- AACTGCTTGGAGAGTGCTTATATGAC -3'