Incidental Mutation 'R0328:Ccl4'
ID 25884
Institutional Source Beutler Lab
Gene Symbol Ccl4
Ensembl Gene ENSMUSG00000018930
Gene Name C-C motif chemokine ligand 4
Synonyms MIP-1B, MIP-1 beta, Mip1b, AT744.1, Act-2, Scya4
MMRRC Submission 038537-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.173) question?
Stock # R0328 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 83553410-83555509 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 83554383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 59 (S59T)
Ref Sequence ENSEMBL: ENSMUSP00000019074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019074]
AlphaFold P14097
Predicted Effect probably damaging
Transcript: ENSMUST00000019074
AA Change: S59T

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000019074
Gene: ENSMUSG00000018930
AA Change: S59T

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
SCY 31 89 9.92e-32 SMART
Meta Mutation Damage Score 0.1950 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.5%
  • 20x: 90.8%
Validation Efficiency 96% (46/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A T 2: 68,574,624 (GRCm39) H618L possibly damaging Het
Aacs T C 5: 125,593,323 (GRCm39) V642A probably benign Het
Alms1 A G 6: 85,587,796 (GRCm39) probably null Het
Arhgap39 A G 15: 76,636,152 (GRCm39) probably benign Het
Bard1 C T 1: 71,085,921 (GRCm39) V595I probably benign Het
Bptf T C 11: 106,937,953 (GRCm39) K2713E probably damaging Het
Calhm1 C T 19: 47,129,742 (GRCm39) G260D possibly damaging Het
Ccdc154 A C 17: 25,390,779 (GRCm39) K643T probably benign Het
Cntd1 T C 11: 101,174,259 (GRCm39) S73P probably benign Het
Colgalt2 A T 1: 152,348,859 (GRCm39) D168V probably damaging Het
Fam117a T C 11: 95,266,452 (GRCm39) probably benign Het
Fat1 A G 8: 45,476,827 (GRCm39) T1935A probably benign Het
Fbxw21 T A 9: 108,975,653 (GRCm39) I248F possibly damaging Het
Fhod3 A T 18: 25,246,657 (GRCm39) M1288L probably benign Het
Gm5114 T G 7: 39,057,885 (GRCm39) K578T probably damaging Het
Gxylt2 A T 6: 100,727,496 (GRCm39) probably benign Het
Helz G T 11: 107,495,174 (GRCm39) A383S probably benign Het
Ift172 C A 5: 31,421,195 (GRCm39) E968* probably null Het
Itpripl1 T C 2: 126,983,924 (GRCm39) N66S possibly damaging Het
Kcnma1 A G 14: 23,423,265 (GRCm39) Y686H probably damaging Het
Ndrg1 C A 15: 66,815,008 (GRCm39) probably benign Het
Ogdh T C 11: 6,297,216 (GRCm39) V545A probably benign Het
Or10al5 A G 17: 38,063,284 (GRCm39) I180V possibly damaging Het
P3h3 G A 6: 124,831,269 (GRCm39) probably benign Het
Ppme1 A T 7: 99,983,182 (GRCm39) probably null Het
Prkag1 T G 15: 98,713,563 (GRCm39) D44A probably damaging Het
Prpf39 T C 12: 65,090,145 (GRCm39) probably benign Het
Rabep1 C A 11: 70,810,033 (GRCm39) R489S probably damaging Het
Scn10a A G 9: 119,523,168 (GRCm39) V75A possibly damaging Het
Sema3d T C 5: 12,498,042 (GRCm39) L16P possibly damaging Het
Skida1 T C 2: 18,051,997 (GRCm39) probably benign Het
Sptbn4 T C 7: 27,063,595 (GRCm39) Y2277C probably damaging Het
Syne1 A G 10: 5,298,945 (GRCm39) I1047T possibly damaging Het
Syt17 A G 7: 117,981,216 (GRCm39) Y369H probably benign Het
Tmem131l C T 3: 83,829,238 (GRCm39) probably benign Het
Traf3ip2 A T 10: 39,510,669 (GRCm39) D314V probably damaging Het
Ttc28 T G 5: 111,431,933 (GRCm39) probably benign Het
Ush1c A C 7: 45,874,872 (GRCm39) probably benign Het
Utp20 A T 10: 88,602,969 (GRCm39) Y1884N possibly damaging Het
Vmn2r112 T A 17: 22,824,251 (GRCm39) I502K probably benign Het
Vmn2r60 T C 7: 41,791,744 (GRCm39) probably benign Het
Vmn2r63 T C 7: 42,552,699 (GRCm39) I852M probably benign Het
Vmn2r9 T A 5: 108,995,405 (GRCm39) E414D probably benign Het
Wnt4 A G 4: 137,022,754 (GRCm39) T106A probably damaging Het
Zbtb26 A T 2: 37,326,807 (GRCm39) N76K possibly damaging Het
Zfhx2 T C 14: 55,309,445 (GRCm39) T885A probably benign Het
Other mutations in Ccl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03217:Ccl4 APN 11 83,553,504 (GRCm39) missense unknown
R0302:Ccl4 UTSW 11 83,554,280 (GRCm39) splice site probably benign
R1342:Ccl4 UTSW 11 83,554,402 (GRCm39) splice site probably benign
R2894:Ccl4 UTSW 11 83,554,329 (GRCm39) splice site probably null
R4934:Ccl4 UTSW 11 83,553,504 (GRCm39) missense unknown
R6334:Ccl4 UTSW 11 83,553,504 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GGGTGGATGACCATAGATTTCAGGGAC -3'
(R):5'- CGTGTAGCAACTTCCTCCCCAAAAG -3'

Sequencing Primer
(F):5'- GGTTCCAGTAGTCCATAAGAATGC -3'
(R):5'- AAGCCATTCCTGACTCCAC -3'
Posted On 2013-04-16