Incidental Mutation 'R3720:Zfp935'
ID 258866
Institutional Source Beutler Lab
Gene Symbol Zfp935
Ensembl Gene ENSMUSG00000055228
Gene Name zinc finger protein 935
Synonyms 8430426H19Rik
MMRRC Submission 040711-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R3720 (G1)
Quality Score 183
Status Validated
Chromosome 13
Chromosomal Location 62453715-62558511 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 62455032 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 98 (Q98*)
Ref Sequence ENSEMBL: ENSMUSP00000152739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076195] [ENSMUST00000221747] [ENSMUST00000223247]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000076195
AA Change: Q98*
SMART Domains Protein: ENSMUSP00000075552
Gene: ENSMUSG00000055228
AA Change: Q98*

DomainStartEndE-ValueType
KRAB 4 66 8.26e-16 SMART
ZnF_C2H2 133 155 2.09e-3 SMART
ZnF_C2H2 161 183 1.4e-4 SMART
ZnF_C2H2 189 211 2.57e-3 SMART
ZnF_C2H2 217 239 5.5e-3 SMART
ZnF_C2H2 245 267 7.26e-3 SMART
ZnF_C2H2 273 295 1.4e-4 SMART
ZnF_C2H2 301 323 8.6e-5 SMART
ZnF_C2H2 329 351 1.2e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221260
Predicted Effect possibly damaging
Transcript: ENSMUST00000221747
AA Change: T118I

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221951
Predicted Effect probably null
Transcript: ENSMUST00000223247
AA Change: Q98*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 93% (40/43)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Appl1 G A 14: 26,927,844 (GRCm38) T575M probably damaging Het
Atp2c1 A T 9: 105,422,976 (GRCm38) M708K probably damaging Het
C9 A G 15: 6,483,119 (GRCm38) T241A possibly damaging Het
Ccrl2 T C 9: 111,056,364 (GRCm38) D22G probably benign Het
Cd47 A G 16: 49,867,842 (GRCm38) I42V probably benign Het
Cntnap5c T C 17: 58,330,202 (GRCm38) S1025P probably benign Het
Col8a1 T C 16: 57,626,916 (GRCm38) M744V unknown Het
Cstf3 A G 2: 104,653,086 (GRCm38) probably benign Het
Dnah8 G A 17: 30,854,898 (GRCm38) R4514H probably damaging Het
Dnai1 G A 4: 41,602,615 (GRCm38) R113H probably damaging Het
Fry T C 5: 150,454,572 (GRCm38) S410P probably damaging Het
Glt6d1 ACCC ACCCC 2: 25,795,167 (GRCm38) probably null Het
Gm10717 A G 9: 3,025,532 (GRCm38) Y39C probably benign Het
Hivep1 C T 13: 42,158,601 (GRCm38) T1439I probably benign Het
Iqgap2 T C 13: 95,668,528 (GRCm38) probably null Het
Kbtbd11 T A 8: 15,029,118 (GRCm38) C572* probably null Het
Kif1c T C 11: 70,703,771 (GRCm38) F86L possibly damaging Het
Kirrel1 C T 3: 87,089,151 (GRCm38) M380I probably null Het
Ldb1 C T 19: 46,044,892 (GRCm38) probably benign Het
Lrmda T A 14: 22,027,331 (GRCm38) probably benign Het
Med23 T C 10: 24,891,120 (GRCm38) L369S probably damaging Het
Mei1 A G 15: 82,103,204 (GRCm38) H399R possibly damaging Het
Myo1b G T 1: 51,776,346 (GRCm38) H614N possibly damaging Het
Neurl1b C T 17: 26,414,975 (GRCm38) T4M probably damaging Het
Or10al7 T C 17: 38,055,368 (GRCm38) Y66C probably damaging Het
Or5t15 T C 2: 86,851,591 (GRCm38) T36A probably benign Het
Polg G A 7: 79,456,791 (GRCm38) Q163* probably null Het
Pramel12 A G 4: 143,419,379 (GRCm38) T473A probably benign Het
Sdk2 G A 11: 113,800,244 (GRCm38) P1835L probably damaging Het
Slc35a5 A T 16: 45,147,322 (GRCm38) I138N probably damaging Het
Snx31 T C 15: 36,523,558 (GRCm38) probably null Het
Speg A T 1: 75,426,782 (GRCm38) H2590L probably damaging Het
Spink4 T A 4: 40,929,136 (GRCm38) C54S probably damaging Het
Swap70 A G 7: 110,270,047 (GRCm38) E349G probably damaging Het
Sybu A G 15: 44,672,632 (GRCm38) V766A possibly damaging Het
Tns3 G A 11: 8,492,999 (GRCm38) R455W probably damaging Het
Tnxb T A 17: 34,712,964 (GRCm38) V2157E possibly damaging Het
Trak2 A T 1: 58,946,245 (GRCm38) probably null Het
Trav18 C T 14: 53,831,617 (GRCm38) R39C possibly damaging Het
Uroc1 G A 6: 90,346,355 (GRCm38) V352M probably damaging Het
Zfp106 A C 2: 120,534,599 (GRCm38) I442M probably benign Het
Other mutations in Zfp935
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Zfp935 APN 13 62,454,464 (GRCm38) missense probably benign 0.33
IGL02169:Zfp935 APN 13 62,456,931 (GRCm38) critical splice donor site probably null
IGL02570:Zfp935 APN 13 62,456,978 (GRCm38) missense probably damaging 1.00
IGL02756:Zfp935 APN 13 62,454,887 (GRCm38) nonsense probably null
IGL03338:Zfp935 APN 13 62,454,433 (GRCm38) missense probably benign 0.11
R1252:Zfp935 UTSW 13 62,454,541 (GRCm38) missense probably damaging 1.00
R1503:Zfp935 UTSW 13 62,455,137 (GRCm38) missense possibly damaging 0.65
R2425:Zfp935 UTSW 13 62,455,108 (GRCm38) missense probably benign 0.02
R4819:Zfp935 UTSW 13 62,454,417 (GRCm38) missense probably damaging 1.00
R5391:Zfp935 UTSW 13 62,454,818 (GRCm38) nonsense probably null
R6253:Zfp935 UTSW 13 62,454,871 (GRCm38) missense probably benign 0.02
R6742:Zfp935 UTSW 13 62,454,479 (GRCm38) missense probably damaging 1.00
R9447:Zfp935 UTSW 13 62,455,028 (GRCm38) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- AGGGTTTCTCTCCAGTATGAATTC -3'
(R):5'- TGGTAAAGCTCTCACATGGG -3'

Sequencing Primer
(F):5'- CATGCCTTTTAAGATGACTGGG -3'
(R):5'- GCCAATTCTCTTCTCAGGTGTGAAAG -3'
Posted On 2015-01-23