Incidental Mutation 'R3720:Zfp935'
ID 258866
Institutional Source Beutler Lab
Gene Symbol Zfp935
Ensembl Gene ENSMUSG00000055228
Gene Name zinc finger protein 935
Synonyms 8430426H19Rik
MMRRC Submission 040711-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R3720 (G1)
Quality Score 183
Status Validated
Chromosome 13
Chromosomal Location 62600830-62614626 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 62602846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 98 (Q98*)
Ref Sequence ENSEMBL: ENSMUSP00000152739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076195] [ENSMUST00000221747] [ENSMUST00000223247]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000076195
AA Change: Q98*
SMART Domains Protein: ENSMUSP00000075552
Gene: ENSMUSG00000055228
AA Change: Q98*

DomainStartEndE-ValueType
KRAB 4 66 8.26e-16 SMART
ZnF_C2H2 133 155 2.09e-3 SMART
ZnF_C2H2 161 183 1.4e-4 SMART
ZnF_C2H2 189 211 2.57e-3 SMART
ZnF_C2H2 217 239 5.5e-3 SMART
ZnF_C2H2 245 267 7.26e-3 SMART
ZnF_C2H2 273 295 1.4e-4 SMART
ZnF_C2H2 301 323 8.6e-5 SMART
ZnF_C2H2 329 351 1.2e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221260
Predicted Effect possibly damaging
Transcript: ENSMUST00000221747
AA Change: T118I

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221951
Predicted Effect probably null
Transcript: ENSMUST00000223247
AA Change: Q98*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 93% (40/43)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Appl1 G A 14: 26,649,801 (GRCm39) T575M probably damaging Het
Atp2c1 A T 9: 105,300,175 (GRCm39) M708K probably damaging Het
C9 A G 15: 6,512,600 (GRCm39) T241A possibly damaging Het
Ccrl2 T C 9: 110,885,432 (GRCm39) D22G probably benign Het
Cd47 A G 16: 49,688,205 (GRCm39) I42V probably benign Het
Cntnap5c T C 17: 58,637,197 (GRCm39) S1025P probably benign Het
Col8a1 T C 16: 57,447,279 (GRCm39) M744V unknown Het
Cstf3 A G 2: 104,483,431 (GRCm39) probably benign Het
Dnah8 G A 17: 31,073,872 (GRCm39) R4514H probably damaging Het
Dnai1 G A 4: 41,602,615 (GRCm39) R113H probably damaging Het
Fry T C 5: 150,378,037 (GRCm39) S410P probably damaging Het
Glt6d1 ACCC ACCCC 2: 25,685,179 (GRCm39) probably null Het
Gm10717 A G 9: 3,025,532 (GRCm39) Y39C probably benign Het
Hivep1 C T 13: 42,312,077 (GRCm39) T1439I probably benign Het
Iqgap2 T C 13: 95,805,036 (GRCm39) probably null Het
Kbtbd11 T A 8: 15,079,118 (GRCm39) C572* probably null Het
Kif1c T C 11: 70,594,597 (GRCm39) F86L possibly damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Ldb1 C T 19: 46,033,331 (GRCm39) probably benign Het
Lrmda T A 14: 22,077,399 (GRCm39) probably benign Het
Med23 T C 10: 24,767,018 (GRCm39) L369S probably damaging Het
Mei1 A G 15: 81,987,405 (GRCm39) H399R possibly damaging Het
Myo1b G T 1: 51,815,505 (GRCm39) H614N possibly damaging Het
Neurl1b C T 17: 26,633,949 (GRCm39) T4M probably damaging Het
Or10al7 T C 17: 38,366,259 (GRCm39) Y66C probably damaging Het
Or5t15 T C 2: 86,681,935 (GRCm39) T36A probably benign Het
Polg G A 7: 79,106,539 (GRCm39) Q163* probably null Het
Pramel12 A G 4: 143,145,949 (GRCm39) T473A probably benign Het
Sdk2 G A 11: 113,691,070 (GRCm39) P1835L probably damaging Het
Slc35a5 A T 16: 44,967,685 (GRCm39) I138N probably damaging Het
Snx31 T C 15: 36,523,704 (GRCm39) probably null Het
Speg A T 1: 75,403,426 (GRCm39) H2590L probably damaging Het
Spink4 T A 4: 40,929,136 (GRCm39) C54S probably damaging Het
Swap70 A G 7: 109,869,254 (GRCm39) E349G probably damaging Het
Sybu A G 15: 44,536,028 (GRCm39) V766A possibly damaging Het
Tns3 G A 11: 8,442,999 (GRCm39) R455W probably damaging Het
Tnxb T A 17: 34,931,938 (GRCm39) V2157E possibly damaging Het
Trak2 A T 1: 58,985,404 (GRCm39) probably null Het
Trav18 C T 14: 54,069,074 (GRCm39) R39C possibly damaging Het
Uroc1 G A 6: 90,323,337 (GRCm39) V352M probably damaging Het
Zfp106 A C 2: 120,365,080 (GRCm39) I442M probably benign Het
Other mutations in Zfp935
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Zfp935 APN 13 62,602,278 (GRCm39) missense probably benign 0.33
IGL02169:Zfp935 APN 13 62,604,745 (GRCm39) critical splice donor site probably null
IGL02570:Zfp935 APN 13 62,604,792 (GRCm39) missense probably damaging 1.00
IGL02756:Zfp935 APN 13 62,602,701 (GRCm39) nonsense probably null
IGL03338:Zfp935 APN 13 62,602,247 (GRCm39) missense probably benign 0.11
R1252:Zfp935 UTSW 13 62,602,355 (GRCm39) missense probably damaging 1.00
R1503:Zfp935 UTSW 13 62,602,951 (GRCm39) missense possibly damaging 0.65
R2425:Zfp935 UTSW 13 62,602,922 (GRCm39) missense probably benign 0.02
R4819:Zfp935 UTSW 13 62,602,231 (GRCm39) missense probably damaging 1.00
R5391:Zfp935 UTSW 13 62,602,632 (GRCm39) nonsense probably null
R6253:Zfp935 UTSW 13 62,602,685 (GRCm39) missense probably benign 0.02
R6742:Zfp935 UTSW 13 62,602,293 (GRCm39) missense probably damaging 1.00
R9447:Zfp935 UTSW 13 62,602,842 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- AGGGTTTCTCTCCAGTATGAATTC -3'
(R):5'- TGGTAAAGCTCTCACATGGG -3'

Sequencing Primer
(F):5'- CATGCCTTTTAAGATGACTGGG -3'
(R):5'- GCCAATTCTCTTCTCAGGTGTGAAAG -3'
Posted On 2015-01-23