Incidental Mutation 'R0328:Or10al5'
ID 25910
Institutional Source Beutler Lab
Gene Symbol Or10al5
Ensembl Gene ENSMUSG00000060017
Gene Name olfactory receptor family 10 subfamily AL member 5
Synonyms Olfr121, GA_x6K02T2PSCP-2211113-2212078, MOR263-4
MMRRC Submission 038537-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R0328 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38059757-38063895 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38063284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 180 (I180V)
Ref Sequence ENSEMBL: ENSMUSP00000133865 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074555] [ENSMUST00000174675]
AlphaFold Q5CZY0
Predicted Effect probably benign
Transcript: ENSMUST00000074555
AA Change: I180V

PolyPhen 2 Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000084377
Gene: ENSMUSG00000060017
AA Change: I180V

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.9e-56 PFAM
Pfam:7TM_GPCR_Srsx 41 311 2.1e-5 PFAM
Pfam:7tm_1 47 296 8.3e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000174675
AA Change: I180V

PolyPhen 2 Score 0.568 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017
AA Change: I180V

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.5%
  • 20x: 90.8%
Validation Efficiency 96% (46/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A T 2: 68,574,624 (GRCm39) H618L possibly damaging Het
Aacs T C 5: 125,593,323 (GRCm39) V642A probably benign Het
Alms1 A G 6: 85,587,796 (GRCm39) probably null Het
Arhgap39 A G 15: 76,636,152 (GRCm39) probably benign Het
Bard1 C T 1: 71,085,921 (GRCm39) V595I probably benign Het
Bptf T C 11: 106,937,953 (GRCm39) K2713E probably damaging Het
Calhm1 C T 19: 47,129,742 (GRCm39) G260D possibly damaging Het
Ccdc154 A C 17: 25,390,779 (GRCm39) K643T probably benign Het
Ccl4 T A 11: 83,554,383 (GRCm39) S59T probably damaging Het
Cntd1 T C 11: 101,174,259 (GRCm39) S73P probably benign Het
Colgalt2 A T 1: 152,348,859 (GRCm39) D168V probably damaging Het
Fam117a T C 11: 95,266,452 (GRCm39) probably benign Het
Fat1 A G 8: 45,476,827 (GRCm39) T1935A probably benign Het
Fbxw21 T A 9: 108,975,653 (GRCm39) I248F possibly damaging Het
Fhod3 A T 18: 25,246,657 (GRCm39) M1288L probably benign Het
Gm5114 T G 7: 39,057,885 (GRCm39) K578T probably damaging Het
Gxylt2 A T 6: 100,727,496 (GRCm39) probably benign Het
Helz G T 11: 107,495,174 (GRCm39) A383S probably benign Het
Ift172 C A 5: 31,421,195 (GRCm39) E968* probably null Het
Itpripl1 T C 2: 126,983,924 (GRCm39) N66S possibly damaging Het
Kcnma1 A G 14: 23,423,265 (GRCm39) Y686H probably damaging Het
Ndrg1 C A 15: 66,815,008 (GRCm39) probably benign Het
Ogdh T C 11: 6,297,216 (GRCm39) V545A probably benign Het
P3h3 G A 6: 124,831,269 (GRCm39) probably benign Het
Ppme1 A T 7: 99,983,182 (GRCm39) probably null Het
Prkag1 T G 15: 98,713,563 (GRCm39) D44A probably damaging Het
Prpf39 T C 12: 65,090,145 (GRCm39) probably benign Het
Rabep1 C A 11: 70,810,033 (GRCm39) R489S probably damaging Het
Scn10a A G 9: 119,523,168 (GRCm39) V75A possibly damaging Het
Sema3d T C 5: 12,498,042 (GRCm39) L16P possibly damaging Het
Skida1 T C 2: 18,051,997 (GRCm39) probably benign Het
Sptbn4 T C 7: 27,063,595 (GRCm39) Y2277C probably damaging Het
Syne1 A G 10: 5,298,945 (GRCm39) I1047T possibly damaging Het
Syt17 A G 7: 117,981,216 (GRCm39) Y369H probably benign Het
Tmem131l C T 3: 83,829,238 (GRCm39) probably benign Het
Traf3ip2 A T 10: 39,510,669 (GRCm39) D314V probably damaging Het
Ttc28 T G 5: 111,431,933 (GRCm39) probably benign Het
Ush1c A C 7: 45,874,872 (GRCm39) probably benign Het
Utp20 A T 10: 88,602,969 (GRCm39) Y1884N possibly damaging Het
Vmn2r112 T A 17: 22,824,251 (GRCm39) I502K probably benign Het
Vmn2r60 T C 7: 41,791,744 (GRCm39) probably benign Het
Vmn2r63 T C 7: 42,552,699 (GRCm39) I852M probably benign Het
Vmn2r9 T A 5: 108,995,405 (GRCm39) E414D probably benign Het
Wnt4 A G 4: 137,022,754 (GRCm39) T106A probably damaging Het
Zbtb26 A T 2: 37,326,807 (GRCm39) N76K possibly damaging Het
Zfhx2 T C 14: 55,309,445 (GRCm39) T885A probably benign Het
Other mutations in Or10al5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01348:Or10al5 APN 17 38,063,177 (GRCm39) missense probably benign 0.03
R0100:Or10al5 UTSW 17 38,063,594 (GRCm39) missense probably benign 0.12
R1641:Or10al5 UTSW 17 38,062,916 (GRCm39) missense possibly damaging 0.90
R2358:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3711:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3712:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R4658:Or10al5 UTSW 17 38,063,054 (GRCm39) missense probably damaging 1.00
R4913:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R5229:Or10al5 UTSW 17 38,063,192 (GRCm39) missense probably benign 0.00
R5611:Or10al5 UTSW 17 38,062,975 (GRCm39) missense possibly damaging 0.94
R6159:Or10al5 UTSW 17 38,063,038 (GRCm39) missense probably damaging 1.00
R6375:Or10al5 UTSW 17 38,062,990 (GRCm39) missense probably benign
R6500:Or10al5 UTSW 17 38,063,577 (GRCm39) missense probably damaging 1.00
R6818:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R7027:Or10al5 UTSW 17 38,063,300 (GRCm39) missense probably damaging 1.00
R7498:Or10al5 UTSW 17 38,063,242 (GRCm39) missense probably damaging 0.96
R7888:Or10al5 UTSW 17 38,062,888 (GRCm39) missense probably damaging 1.00
R8299:Or10al5 UTSW 17 38,062,891 (GRCm39) nonsense probably null
R9497:Or10al5 UTSW 17 38,062,942 (GRCm39) missense probably damaging 1.00
Z1176:Or10al5 UTSW 17 38,063,658 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGCCATTGCCATCTGCACCAGTC -3'
(R):5'- GGGCCAAGAGTTTGTCCATTCCTG -3'

Sequencing Primer
(F):5'- GATGTGCCACACAGATGTTTTTC -3'
(R):5'- CCATTCCTGGTAAGTGGCTAGAC -3'
Posted On 2013-04-16