|Institutional Source||Beutler Lab|
|Gene Name||hydroxyacid oxidase 2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3177 (G1)|
|Chromosomal Location||98874521-98893239 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 98880328 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000029464 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029464]|
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (21/21)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Electrophoretic variants are known for this locus in kidney. The a allele determines a slow anodally migrating band in all inbred strains tested; the b allele determines a fast band in M. m. castaneus. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hao2||
(F):5'- GCTTCAATGCCTTTCAAACATC -3'
(R):5'- CTGGAATGATCTCCCCTTGC -3'
(F):5'- GTCTACTGTGAACCTGTACTCATTAG -3'
(R):5'- GGAATGATCTCCCCTTGCTTCAGAG -3'