Incidental Mutation 'R3405:Tmem28'
List |< first << previous [record 43 of 47] next >> last >|
Institutional Source Beutler Lab
Gene Symbol Tmem28
Ensembl Gene ENSMUSG00000071719
Gene Nametransmembrane protein 28
SynonymsEG620592, Fam155b
MMRRC Submission 040623-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #R3405 (G1)
Quality Score222
Status Validated
Chromosomal Location99821021-99848790 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 99845503 bp
Amino Acid Change Isoleucine to Valine at position 325 (I325V)
Ref Sequence ENSEMBL: ENSMUSP00000094090 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096363]
Predicted Effect probably benign
Transcript: ENSMUST00000096363
AA Change: I325V

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000094090
Gene: ENSMUSG00000071719
AA Change: I325V

low complexity region 90 112 N/A INTRINSIC
low complexity region 159 176 N/A INTRINSIC
low complexity region 381 401 N/A INTRINSIC
low complexity region 432 444 N/A INTRINSIC
low complexity region 447 457 N/A INTRINSIC
Meta Mutation Damage Score 0.0613 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.4%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 C A 6: 85,667,963 probably benign Het
Bcorl1 T A X: 48,371,007 M1139K probably benign Het
C2cd3 T C 7: 100,390,166 S191P probably benign Het
Cdc27 T C 11: 104,507,200 E778G probably damaging Het
Col3a1 G A 1: 45,338,753 probably benign Het
Cubn C T 2: 13,333,508 V2350I probably benign Het
Dhodh G A 8: 109,603,475 R86* probably null Het
Dnhd1 C T 7: 105,694,761 Q1771* probably null Het
Dpt A C 1: 164,796,931 E67A probably damaging Het
Eif2ak2 A G 17: 78,858,639 probably benign Het
Exo1 A G 1: 175,905,970 K787E possibly damaging Het
Fancm T C 12: 65,075,772 S23P probably benign Het
Fmn1 A G 2: 113,364,348 E131G unknown Het
Gm5612 A T 9: 18,427,853 probably benign Het
Gsdma T C 11: 98,673,138 probably benign Het
Hormad2 T G 11: 4,424,302 Q88P probably damaging Het
Immp2l T A 12: 41,110,847 L48* probably null Het
Kcne4 C T 1: 78,817,971 A112V possibly damaging Het
Lamb1 C T 12: 31,287,529 R372C probably damaging Het
Lrrc30 A G 17: 67,632,180 L135P probably damaging Het
Ltn1 A T 16: 87,416,215 V486D probably damaging Het
Mab21l3 C A 3: 101,823,531 V131F probably damaging Het
Map3k4 A T 17: 12,256,781 F809Y probably damaging Het
Mki67 T A 7: 135,707,475 T416S probably benign Het
Mlst8 A T 17: 24,478,125 M56K probably benign Het
Mmp9 A G 2: 164,949,390 Y160C probably damaging Het
Mslnl A G 17: 25,746,181 Y507C probably damaging Het
Myl12a A T 17: 70,994,742 M130K probably benign Het
Myrfl A G 10: 116,822,865 F396L probably damaging Het
Ncf2 A G 1: 152,825,947 probably benign Het
Nlrp9c T A 7: 26,385,282 I291F probably benign Het
Nrp1 T A 8: 128,498,088 Y777* probably null Het
Ogdh T C 11: 6,349,462 V776A probably damaging Het
Pcdh17 T A 14: 84,446,622 D176E probably damaging Het
Plg G T 17: 12,403,209 S472I possibly damaging Het
Pnlip A G 19: 58,680,759 T397A probably benign Het
Rbfox3 T A 11: 118,496,457 Q277L possibly damaging Het
Senp7 T A 16: 56,188,277 W1007R probably damaging Het
Stap2 A T 17: 55,997,511 W374R probably benign Het
Szt2 A G 4: 118,394,020 V297A probably benign Het
Thada A T 17: 84,230,785 probably benign Het
Ticrr G C 7: 79,694,791 S1468T probably benign Het
Uvssa G T 5: 33,389,818 G243C probably damaging Het
Vmn2r-ps159 G T 4: 156,334,397 noncoding transcript Het
Vwa8 T A 14: 79,164,220 probably benign Het
Zfp609 A T 9: 65,701,172 M1142K possibly damaging Het
Other mutations in Tmem28
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3406:Tmem28 UTSW X 99845503 missense probably benign 0.02
R3932:Tmem28 UTSW X 99821864 missense possibly damaging 0.94
R3933:Tmem28 UTSW X 99821864 missense possibly damaging 0.94
RF011:Tmem28 UTSW X 99821361 small insertion probably benign
RF017:Tmem28 UTSW X 99821365 small insertion probably benign
RF018:Tmem28 UTSW X 99821361 small insertion probably benign
RF033:Tmem28 UTSW X 99821373 small insertion probably benign
RF039:Tmem28 UTSW X 99821372 small insertion probably benign
RF051:Tmem28 UTSW X 99821362 small insertion probably benign
X0033:Tmem28 UTSW X 99821121 small deletion probably benign
X0036:Tmem28 UTSW X 99821121 small deletion probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-01-23