Mutagenetix > Incidental Mutation

Incidental Mutation 'R3406:Or11g7'

259398

Institutional Source

Beutler Lab

Gene Symbol

Or11g7

Ensembl Gene

ENSMUSG00000095917

Gene Name

olfactory receptor family 11 subfamily G member 7

Synonyms

MOR106-4, Olfr740, GA_x6K02T2PMLR-6167145-6168080

MMRRC Submission

040624-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R3406 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50690511-50693135 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 50690653 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 48 (C48Y)

Ref Sequence

ENSEMBL: ENSMUSP00000148916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]

AlphaFold

E9PV79

Predicted Effect

probably benign
Transcript: ENSMUST00000089838
AA Change: C48Y

PolyPhen 2 Score 0.144 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: C48Y

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.3e-56	PFAM
Pfam:7tm_1	45	294	1.6e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214792
AA Change: C48Y

PolyPhen 2 Score 0.144 (Sensitivity: 0.92; Specificity: 0.86)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 93.4%

Validation Efficiency

98% (52/53)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd18	T	A	3: 40,859,338 (GRCm39)	M1K	probably null	Het
Adam34l	A	T	8: 44,079,089 (GRCm39)	C378*	probably null	Het
Bdkrb2	T	C	12: 105,558,755 (GRCm39)	V332A	possibly damaging	Het
Cdc27	T	C	11: 104,398,026 (GRCm39)	E778G	probably damaging	Het
Chd4	C	A	6: 125,098,970 (GRCm39)	T1586K	probably benign	Het
Cnga3	A	G	1: 37,301,146 (GRCm39)	E622G	probably benign	Het
Dbh	A	G	2: 27,064,977 (GRCm39)	D396G	possibly damaging	Het
Dhodh	G	A	8: 110,330,107 (GRCm39)	R86*	probably null	Het
Dpt	A	C	1: 164,624,500 (GRCm39)	E67A	probably damaging	Het
Eif2ak2	A	G	17: 79,166,068 (GRCm39)		probably benign	Het
Esp4	T	A	17: 40,913,336 (GRCm39)	L68M	possibly damaging	Het
Exo1	A	G	1: 175,733,536 (GRCm39)	K787E	possibly damaging	Het
Fbxo38	T	C	18: 62,647,914 (GRCm39)	T875A	probably damaging	Het
Gsdma	T	C	11: 98,563,964 (GRCm39)		probably benign	Het
Hemk1	G	A	9: 107,214,415 (GRCm39)	Q6*	probably null	Het
Hmcn2	C	T	2: 31,323,284 (GRCm39)		probably benign	Het
Hook2	A	G	8: 85,720,613 (GRCm39)		probably benign	Het
Irx3	A	G	8: 92,525,555 (GRCm39)	S507P	unknown	Het
Kazn	C	A	4: 141,966,506 (GRCm39)		probably benign	Het
Kcne4	C	T	1: 78,795,688 (GRCm39)	A112V	possibly damaging	Het
Lamb1	C	T	12: 31,337,528 (GRCm39)	R372C	probably damaging	Het
Lrrc30	A	G	17: 67,939,175 (GRCm39)	L135P	probably damaging	Het
Lyst	T	A	13: 13,809,815 (GRCm39)	M495K	possibly damaging	Het
Mab21l3	C	A	3: 101,730,847 (GRCm39)	V131F	probably damaging	Het
Mki67	T	A	7: 135,309,204 (GRCm39)	T416S	probably benign	Het
Mlst8	A	T	17: 24,697,099 (GRCm39)	M56K	probably benign	Het
Mmp9	A	G	2: 164,791,310 (GRCm39)	Y160C	probably damaging	Het
Mslnl	A	G	17: 25,965,155 (GRCm39)	Y507C	probably damaging	Het
Muc6	G	A	7: 141,218,313 (GRCm39)	S2120F	possibly damaging	Het
Myl12a	A	T	17: 71,301,737 (GRCm39)	M130K	probably benign	Het
Nalf2	A	G	X: 98,889,109 (GRCm39)	I325V	probably benign	Het
Ncdn	C	T	4: 126,642,388 (GRCm39)	R423Q	probably benign	Het
Ncf2	A	G	1: 152,701,698 (GRCm39)		probably benign	Het
Nek8	G	T	11: 78,061,572 (GRCm39)	S319*	probably null	Het
Or52m2	T	C	7: 102,263,993 (GRCm39)	M68V	possibly damaging	Het
Pcdh17	T	A	14: 84,684,062 (GRCm39)	D176E	probably damaging	Het
Pcdhb15	C	A	18: 37,608,442 (GRCm39)	A558E	probably benign	Het
Plrg1	T	A	3: 82,978,526 (GRCm39)	W431R	probably damaging	Het
Rbfox3	T	A	11: 118,387,283 (GRCm39)	Q277L	possibly damaging	Het
Rpgrip1	G	A	14: 52,382,666 (GRCm39)	D600N	possibly damaging	Het
Siah3	A	G	14: 75,763,421 (GRCm39)	D224G	probably damaging	Het
Slc22a6	T	C	19: 8,598,675 (GRCm39)	L244P	probably damaging	Het
Stap2	A	T	17: 56,304,511 (GRCm39)	W374R	probably benign	Het
Tbck	T	A	3: 132,432,845 (GRCm39)	N418K	probably benign	Het
Tcp11x2	T	C	X: 134,555,733 (GRCm39)	N474S	probably damaging	Het
Tenm3	A	C	8: 48,681,590 (GRCm39)	V2680G	probably damaging	Het
Thada	A	T	17: 84,538,213 (GRCm39)		probably benign	Het
Tlr6	C	T	5: 65,110,772 (GRCm39)	V712M	probably damaging	Het
Uvssa	G	T	5: 33,547,162 (GRCm39)	G243C	probably damaging	Het
Vwa8	T	A	14: 79,401,660 (GRCm39)		probably benign	Het
Znrf2	A	T	6: 54,861,776 (GRCm39)	N229I	probably damaging	Het

Other mutations in Or11g7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01663:Or11g7	APN	14	50,690,607 (GRCm39)	missense	probably benign	0.04
IGL02117:Or11g7	APN	14	50,691,399 (GRCm39)	missense	possibly damaging	0.91
IGL02663:Or11g7	APN	14	50,691,309 (GRCm39)	missense	probably benign	0.02
IGL02858:Or11g7	APN	14	50,690,507 (GRCm39)	utr 5 prime	probably benign
IGL02955:Or11g7	APN	14	50,691,442 (GRCm39)	missense	probably damaging	0.99
IGL03210:Or11g7	APN	14	50,691,440 (GRCm39)	missense	probably benign	0.10
IGL03249:Or11g7	APN	14	50,690,668 (GRCm39)	missense	probably damaging	0.98
G1Funyon:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
R0946:Or11g7	UTSW	14	50,691,130 (GRCm39)	missense	probably benign	0.13
R1449:Or11g7	UTSW	14	50,691,378 (GRCm39)	missense	probably damaging	1.00
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1513:Or11g7	UTSW	14	50,691,138 (GRCm39)	missense	probably benign	0.00
R1908:Or11g7	UTSW	14	50,691,295 (GRCm39)	missense	probably damaging	0.99
R2422:Or11g7	UTSW	14	50,690,893 (GRCm39)	missense	probably damaging	1.00
R4184:Or11g7	UTSW	14	50,690,827 (GRCm39)	missense	probably damaging	1.00
R4795:Or11g7	UTSW	14	50,690,874 (GRCm39)	missense	probably damaging	0.96
R5028:Or11g7	UTSW	14	50,691,196 (GRCm39)	missense	probably damaging	1.00
R5436:Or11g7	UTSW	14	50,691,184 (GRCm39)	missense	probably damaging	1.00
R6057:Or11g7	UTSW	14	50,691,201 (GRCm39)	nonsense	probably null
R6455:Or11g7	UTSW	14	50,691,042 (GRCm39)	missense	possibly damaging	0.92
R6903:Or11g7	UTSW	14	50,691,412 (GRCm39)	missense	possibly damaging	0.93
R6998:Or11g7	UTSW	14	50,690,890 (GRCm39)	missense	probably benign	0.29
R7671:Or11g7	UTSW	14	50,691,342 (GRCm39)	missense	probably benign	0.04
R8048:Or11g7	UTSW	14	50,691,373 (GRCm39)	missense	possibly damaging	0.52
R8301:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
X0066:Or11g7	UTSW	14	50,691,115 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CTGATGCTTTCACAGGTCACAG -3'
(R):5'- ATCAAATGCCATGACTGCCAG -3'

Sequencing Primer
(F):5'- GCTTTCACAGGTCACAGACAGATG -3'
(R):5'- GGCATTCTGTAGAACCCAAGG -3'

Posted On

2015-01-23