Incidental Mutation 'R0329:Myo9a'
| ID |
25958 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo9a
|
| Ensembl Gene |
ENSMUSG00000039585 |
| Gene Name |
myosin IXa |
| Synonyms |
C130068I12Rik, 4732465J09Rik |
| MMRRC Submission |
038538-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0329 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
59658179-59836149 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 59830960 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 2368
(T2368S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119401
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128341]
[ENSMUST00000135298]
[ENSMUST00000136740]
|
| AlphaFold |
Q8C170 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000128341
AA Change: T2368S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000119401
Gene: ENSMUSG00000039585
AA Change: T2368S
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1685 |
1938 |
6e-89 |
BLAST |
|
low complexity region
|
1982 |
1993 |
N/A |
INTRINSIC |
|
C1
|
2002 |
2050 |
2.6e-9 |
SMART |
|
RhoGAP
|
2075 |
2250 |
3.36e-73 |
SMART |
|
coiled coil region
|
2320 |
2360 |
N/A |
INTRINSIC |
|
low complexity region
|
2419 |
2438 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135298
AA Change: T2439S
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000117432
Gene: ENSMUSG00000039585
AA Change: T2439S
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1759 |
N/A |
INTRINSIC |
|
low complexity region
|
2053 |
2064 |
N/A |
INTRINSIC |
|
C1
|
2073 |
2121 |
2.6e-9 |
SMART |
|
RhoGAP
|
2146 |
2321 |
3.36e-73 |
SMART |
|
coiled coil region
|
2391 |
2431 |
N/A |
INTRINSIC |
|
low complexity region
|
2490 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000136740
AA Change: T2457S
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000122852
Gene: ENSMUSG00000039585
AA Change: T2457S
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1759 |
N/A |
INTRINSIC |
|
low complexity region
|
2053 |
2064 |
N/A |
INTRINSIC |
|
C1
|
2073 |
2121 |
2.6e-9 |
SMART |
|
RhoGAP
|
2146 |
2321 |
3.36e-73 |
SMART |
|
coiled coil region
|
2409 |
2449 |
N/A |
INTRINSIC |
|
low complexity region
|
2508 |
2527 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215963
|
| Meta Mutation Damage Score |
0.1028 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.8%
- 10x: 95.0%
- 20x: 89.0%
|
| Validation Efficiency |
99% (107/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous KO leads to obstructive hydrocephaly caused by blockage of the third ventricle and the rostral aqueduct caused by developmental failures of their ependymal cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 107 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
T |
11: 9,349,430 (GRCm39) |
H3668L |
probably damaging |
Het |
| Acsbg3 |
A |
T |
17: 57,190,631 (GRCm39) |
I400F |
probably benign |
Het |
| Acvr1c |
T |
C |
2: 58,174,850 (GRCm39) |
T313A |
probably damaging |
Het |
| Adam28 |
T |
C |
14: 68,855,188 (GRCm39) |
K651R |
probably damaging |
Het |
| Adamtsl3 |
A |
T |
7: 82,171,198 (GRCm39) |
D417V |
probably damaging |
Het |
| Adgrf4 |
A |
T |
17: 42,978,204 (GRCm39) |
C380S |
probably damaging |
Het |
| AI597479 |
T |
G |
1: 43,150,277 (GRCm39) |
L129R |
probably benign |
Het |
| Anpep |
C |
T |
7: 79,488,004 (GRCm39) |
E518K |
probably benign |
Het |
| Anxa7 |
A |
C |
14: 20,519,566 (GRCm39) |
|
probably null |
Het |
| Arb2a |
T |
A |
13: 77,910,070 (GRCm39) |
|
probably benign |
Het |
| Arhgap22 |
A |
G |
14: 33,091,374 (GRCm39) |
R650G |
possibly damaging |
Het |
| Atp8a1 |
T |
A |
5: 67,969,416 (GRCm39) |
|
probably benign |
Het |
| Bcr |
C |
T |
10: 75,017,466 (GRCm39) |
T1209I |
possibly damaging |
Het |
| Bmpr1a |
C |
T |
14: 34,151,734 (GRCm39) |
S185N |
probably benign |
Het |
| Calcoco1 |
A |
T |
15: 102,624,198 (GRCm39) |
M246K |
probably benign |
Het |
| Casp12 |
T |
A |
9: 5,345,534 (GRCm39) |
|
probably benign |
Het |
| Ccno |
T |
A |
13: 113,126,530 (GRCm39) |
L333Q |
probably damaging |
Het |
| Cdhr2 |
T |
A |
13: 54,882,614 (GRCm39) |
|
probably benign |
Het |
| Cftr |
T |
A |
6: 18,226,096 (GRCm39) |
M318K |
probably null |
Het |
| Ckmt2 |
T |
A |
13: 92,011,322 (GRCm39) |
D96V |
possibly damaging |
Het |
| Cnnm1 |
C |
T |
19: 43,430,349 (GRCm39) |
P489L |
probably damaging |
Het |
| Cntnap1 |
A |
T |
11: 101,079,135 (GRCm39) |
D1175V |
probably damaging |
Het |
| Cpne5 |
A |
T |
17: 29,430,634 (GRCm39) |
L92H |
probably damaging |
Het |
| Crcp |
C |
A |
5: 130,071,083 (GRCm39) |
Q61K |
possibly damaging |
Het |
| Crppa |
C |
T |
12: 36,431,837 (GRCm39) |
A22V |
possibly damaging |
Het |
| Dcaf8 |
T |
A |
1: 172,014,978 (GRCm39) |
D414E |
probably benign |
Het |
| Ddx28 |
T |
C |
8: 106,736,877 (GRCm39) |
T394A |
probably benign |
Het |
| Ddx55 |
T |
C |
5: 124,697,210 (GRCm39) |
F191L |
probably benign |
Het |
| Dnaaf1 |
T |
C |
8: 120,322,756 (GRCm39) |
|
probably benign |
Het |
| Dnaaf2 |
C |
A |
12: 69,244,518 (GRCm39) |
R181L |
probably damaging |
Het |
| Elac2 |
A |
G |
11: 64,870,136 (GRCm39) |
Y67C |
probably damaging |
Het |
| Elf5 |
A |
G |
2: 103,260,765 (GRCm39) |
|
probably benign |
Het |
| Emcn |
T |
A |
3: 137,122,575 (GRCm39) |
|
probably benign |
Het |
| Erbb4 |
T |
C |
1: 68,337,439 (GRCm39) |
|
probably benign |
Het |
| Erbin |
C |
A |
13: 104,005,373 (GRCm39) |
C114F |
probably damaging |
Het |
| Etfdh |
T |
C |
3: 79,517,151 (GRCm39) |
I353V |
probably benign |
Het |
| Fads2b |
T |
A |
2: 85,348,895 (GRCm39) |
R72S |
probably benign |
Het |
| Fbxl12 |
C |
T |
9: 20,549,776 (GRCm39) |
G316D |
probably damaging |
Het |
| Gbf1 |
G |
A |
19: 46,260,709 (GRCm39) |
|
probably null |
Het |
| Gbp2b |
T |
G |
3: 142,313,937 (GRCm39) |
S406A |
probably benign |
Het |
| Gli3 |
T |
G |
13: 15,898,143 (GRCm39) |
L741R |
probably damaging |
Het |
| Gmip |
G |
T |
8: 70,263,468 (GRCm39) |
S70I |
probably benign |
Het |
| Gnptab |
T |
C |
10: 88,276,171 (GRCm39) |
S1153P |
probably damaging |
Het |
| Gp1ba |
A |
G |
11: 70,531,235 (GRCm39) |
|
probably benign |
Het |
| Gramd1a |
T |
C |
7: 30,837,679 (GRCm39) |
D360G |
possibly damaging |
Het |
| Hectd4 |
T |
C |
5: 121,397,927 (GRCm39) |
I285T |
probably benign |
Het |
| Hrh4 |
A |
G |
18: 13,140,302 (GRCm39) |
|
probably benign |
Het |
| Hsp90b1 |
T |
C |
10: 86,530,019 (GRCm39) |
E226G |
probably damaging |
Het |
| Hspa13 |
A |
T |
16: 75,562,018 (GRCm39) |
D60E |
probably damaging |
Het |
| Htt |
T |
A |
5: 34,974,478 (GRCm39) |
|
probably benign |
Het |
| Iqca1l |
T |
C |
5: 24,750,783 (GRCm39) |
|
probably null |
Het |
| Kif14 |
G |
C |
1: 136,423,764 (GRCm39) |
|
probably benign |
Het |
| Kit |
T |
G |
5: 75,813,489 (GRCm39) |
V888G |
probably damaging |
Het |
| Lpin3 |
T |
C |
2: 160,747,225 (GRCm39) |
V827A |
probably benign |
Het |
| Lrriq4 |
T |
C |
3: 30,709,873 (GRCm39) |
S406P |
probably benign |
Het |
| Man2c1 |
T |
C |
9: 57,048,467 (GRCm39) |
V777A |
probably benign |
Het |
| Mcm8 |
A |
G |
2: 132,661,914 (GRCm39) |
K83E |
possibly damaging |
Het |
| Mep1a |
A |
G |
17: 43,808,789 (GRCm39) |
|
probably null |
Het |
| Mtor |
T |
A |
4: 148,568,837 (GRCm39) |
V1119E |
probably benign |
Het |
| Mybpc2 |
C |
T |
7: 44,158,453 (GRCm39) |
A710T |
possibly damaging |
Het |
| Nbeal1 |
A |
G |
1: 60,307,222 (GRCm39) |
Y1684C |
probably damaging |
Het |
| Npm3 |
A |
G |
19: 45,737,965 (GRCm39) |
F11L |
probably benign |
Het |
| Nutf2 |
T |
A |
8: 106,602,995 (GRCm39) |
S37T |
probably damaging |
Het |
| Obscn |
T |
A |
11: 58,931,267 (GRCm39) |
I5790F |
probably damaging |
Het |
| Obscn |
A |
T |
11: 58,943,332 (GRCm39) |
D4833E |
probably damaging |
Het |
| Or2g1 |
A |
T |
17: 38,106,880 (GRCm39) |
M182L |
probably benign |
Het |
| Or7d9 |
T |
A |
9: 20,197,153 (GRCm39) |
S61T |
possibly damaging |
Het |
| Or8g35 |
T |
C |
9: 39,381,852 (GRCm39) |
T57A |
possibly damaging |
Het |
| Or9g4b |
T |
A |
2: 85,616,147 (GRCm39) |
C97* |
probably null |
Het |
| Pcdhb1 |
A |
G |
18: 37,400,077 (GRCm39) |
D676G |
possibly damaging |
Het |
| Pcif1 |
G |
T |
2: 164,731,364 (GRCm39) |
R466L |
probably damaging |
Het |
| Pdk1 |
T |
C |
2: 71,726,018 (GRCm39) |
|
probably benign |
Het |
| Phxr2 |
T |
C |
10: 98,961,979 (GRCm39) |
|
probably benign |
Het |
| Pidd1 |
A |
T |
7: 141,019,474 (GRCm39) |
|
probably benign |
Het |
| Plec |
A |
G |
15: 76,075,618 (GRCm39) |
|
probably null |
Het |
| Polr1a |
T |
A |
6: 71,943,400 (GRCm39) |
C1212S |
possibly damaging |
Het |
| Pot1a |
A |
G |
6: 25,778,830 (GRCm39) |
|
probably benign |
Het |
| Prdm5 |
T |
C |
6: 65,839,887 (GRCm39) |
|
probably benign |
Het |
| Primpol |
A |
T |
8: 47,063,496 (GRCm39) |
N53K |
probably damaging |
Het |
| Pyroxd1 |
A |
G |
6: 142,307,702 (GRCm39) |
I491V |
probably benign |
Het |
| Serpinb3b |
G |
T |
1: 107,087,433 (GRCm39) |
N25K |
probably damaging |
Het |
| Slc9b1 |
C |
T |
3: 135,078,996 (GRCm39) |
R218* |
probably null |
Het |
| Ssbp2 |
T |
A |
13: 91,828,698 (GRCm39) |
|
probably null |
Het |
| Stat4 |
A |
G |
1: 52,130,029 (GRCm39) |
|
probably benign |
Het |
| Steap4 |
T |
C |
5: 8,025,829 (GRCm39) |
V130A |
possibly damaging |
Het |
| Stoml2 |
A |
G |
4: 43,030,238 (GRCm39) |
|
probably null |
Het |
| Syne2 |
G |
T |
12: 76,013,727 (GRCm39) |
G2974C |
probably benign |
Het |
| Tfdp2 |
T |
G |
9: 96,188,946 (GRCm39) |
F200V |
probably damaging |
Het |
| Tgm4 |
T |
C |
9: 122,877,622 (GRCm39) |
|
probably null |
Het |
| Tie1 |
C |
A |
4: 118,341,924 (GRCm39) |
R175L |
probably benign |
Het |
| Tmem145 |
A |
G |
7: 25,008,099 (GRCm39) |
|
probably benign |
Het |
| Tsacc |
A |
G |
3: 88,190,169 (GRCm39) |
S94P |
possibly damaging |
Het |
| Tshz3 |
T |
A |
7: 36,469,458 (GRCm39) |
D482E |
probably benign |
Het |
| Tspan33 |
T |
C |
6: 29,711,091 (GRCm39) |
|
probably null |
Het |
| Ugt2b35 |
A |
G |
5: 87,151,264 (GRCm39) |
K290R |
probably null |
Het |
| Unc80 |
T |
C |
1: 66,713,246 (GRCm39) |
L2788P |
possibly damaging |
Het |
| Usp10 |
T |
A |
8: 120,663,296 (GRCm39) |
C39* |
probably null |
Het |
| Utp20 |
T |
A |
10: 88,653,841 (GRCm39) |
T260S |
probably benign |
Het |
| Vmn2r118 |
G |
T |
17: 55,917,717 (GRCm39) |
T265K |
probably damaging |
Het |
| Vmn2r7 |
C |
A |
3: 64,598,439 (GRCm39) |
C797F |
probably damaging |
Het |
| Vmn2r98 |
A |
C |
17: 19,286,609 (GRCm39) |
H369P |
probably benign |
Het |
| Vps39 |
A |
T |
2: 120,169,268 (GRCm39) |
Y245N |
possibly damaging |
Het |
| Wdr27 |
A |
G |
17: 15,154,721 (GRCm39) |
|
probably benign |
Het |
| Ythdc2 |
A |
G |
18: 44,998,127 (GRCm39) |
|
probably benign |
Het |
| Zcwpw2 |
C |
A |
9: 117,843,123 (GRCm39) |
|
noncoding transcript |
Het |
| Zdhhc1 |
C |
A |
8: 106,210,175 (GRCm39) |
A81S |
probably benign |
Het |
| Zfp729a |
G |
T |
13: 67,768,473 (GRCm39) |
H585Q |
probably damaging |
Het |
|
| Other mutations in Myo9a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Myo9a
|
APN |
9 |
59,750,342 (GRCm39) |
splice site |
probably benign |
|
|
IGL00510:Myo9a
|
APN |
9 |
59,739,464 (GRCm39) |
splice site |
probably benign |
|
|
IGL00710:Myo9a
|
APN |
9 |
59,782,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Myo9a
|
APN |
9 |
59,807,655 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01087:Myo9a
|
APN |
9 |
59,697,361 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01145:Myo9a
|
APN |
9 |
59,762,658 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01403:Myo9a
|
APN |
9 |
59,778,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01528:Myo9a
|
APN |
9 |
59,686,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Myo9a
|
APN |
9 |
59,778,119 (GRCm39) |
nonsense |
probably null |
|
|
IGL01701:Myo9a
|
APN |
9 |
59,791,877 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01918:Myo9a
|
APN |
9 |
59,686,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02026:Myo9a
|
APN |
9 |
59,813,245 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02139:Myo9a
|
APN |
9 |
59,687,275 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02176:Myo9a
|
APN |
9 |
59,777,836 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02272:Myo9a
|
APN |
9 |
59,791,883 (GRCm39) |
splice site |
probably benign |
|
|
IGL02283:Myo9a
|
APN |
9 |
59,778,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02499:Myo9a
|
APN |
9 |
59,722,669 (GRCm39) |
splice site |
probably benign |
|
|
IGL02652:Myo9a
|
APN |
9 |
59,771,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Myo9a
|
APN |
9 |
59,832,187 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02878:Myo9a
|
APN |
9 |
59,815,583 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02982:Myo9a
|
APN |
9 |
59,815,491 (GRCm39) |
nonsense |
probably null |
|
|
IGL03072:Myo9a
|
APN |
9 |
59,716,725 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03090:Myo9a
|
APN |
9 |
59,801,418 (GRCm39) |
splice site |
probably benign |
|
|
IGL03111:Myo9a
|
APN |
9 |
59,734,526 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03389:Myo9a
|
APN |
9 |
59,776,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
essentials
|
UTSW |
9 |
59,802,149 (GRCm39) |
missense |
probably benign |
0.09 |
|
necessities
|
UTSW |
9 |
59,722,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4402001:Myo9a
|
UTSW |
9 |
59,777,719 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0013:Myo9a
|
UTSW |
9 |
59,767,489 (GRCm39) |
splice site |
probably benign |
|
|
R0013:Myo9a
|
UTSW |
9 |
59,767,489 (GRCm39) |
splice site |
probably benign |
|
|
R0018:Myo9a
|
UTSW |
9 |
59,779,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0018:Myo9a
|
UTSW |
9 |
59,779,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0423:Myo9a
|
UTSW |
9 |
59,802,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Myo9a
|
UTSW |
9 |
59,801,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Myo9a
|
UTSW |
9 |
59,829,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0652:Myo9a
|
UTSW |
9 |
59,779,209 (GRCm39) |
missense |
probably benign |
|
|
R0653:Myo9a
|
UTSW |
9 |
59,832,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Myo9a
|
UTSW |
9 |
59,778,383 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0784:Myo9a
|
UTSW |
9 |
59,803,828 (GRCm39) |
splice site |
probably benign |
|
|
R0842:Myo9a
|
UTSW |
9 |
59,778,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1055:Myo9a
|
UTSW |
9 |
59,762,653 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1056:Myo9a
|
UTSW |
9 |
59,739,484 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Myo9a
|
UTSW |
9 |
59,695,739 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1698:Myo9a
|
UTSW |
9 |
59,775,464 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1715:Myo9a
|
UTSW |
9 |
59,739,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1981:Myo9a
|
UTSW |
9 |
59,801,429 (GRCm39) |
missense |
probably benign |
|
|
R2228:Myo9a
|
UTSW |
9 |
59,801,463 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2272:Myo9a
|
UTSW |
9 |
59,722,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Myo9a
|
UTSW |
9 |
59,687,048 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2990:Myo9a
|
UTSW |
9 |
59,832,172 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3161:Myo9a
|
UTSW |
9 |
59,739,598 (GRCm39) |
splice site |
probably benign |
|
|
R3721:Myo9a
|
UTSW |
9 |
59,775,463 (GRCm39) |
missense |
probably benign |
|
|
R3928:Myo9a
|
UTSW |
9 |
59,802,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Myo9a
|
UTSW |
9 |
59,802,149 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4212:Myo9a
|
UTSW |
9 |
59,813,349 (GRCm39) |
nonsense |
probably null |
|
|
R4610:Myo9a
|
UTSW |
9 |
59,779,165 (GRCm39) |
missense |
probably benign |
|
|
R4616:Myo9a
|
UTSW |
9 |
59,728,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4621:Myo9a
|
UTSW |
9 |
59,778,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4623:Myo9a
|
UTSW |
9 |
59,778,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4632:Myo9a
|
UTSW |
9 |
59,776,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4657:Myo9a
|
UTSW |
9 |
59,782,699 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4892:Myo9a
|
UTSW |
9 |
59,731,525 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Myo9a
|
UTSW |
9 |
59,803,800 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4966:Myo9a
|
UTSW |
9 |
59,779,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4993:Myo9a
|
UTSW |
9 |
59,768,755 (GRCm39) |
nonsense |
probably null |
|
|
R5160:Myo9a
|
UTSW |
9 |
59,779,085 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5233:Myo9a
|
UTSW |
9 |
59,817,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5271:Myo9a
|
UTSW |
9 |
59,814,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5308:Myo9a
|
UTSW |
9 |
59,771,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5367:Myo9a
|
UTSW |
9 |
59,807,732 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5432:Myo9a
|
UTSW |
9 |
59,772,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5459:Myo9a
|
UTSW |
9 |
59,791,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5511:Myo9a
|
UTSW |
9 |
59,687,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5568:Myo9a
|
UTSW |
9 |
59,781,911 (GRCm39) |
missense |
probably benign |
|
|
R5573:Myo9a
|
UTSW |
9 |
59,778,284 (GRCm39) |
missense |
probably benign |
|
|
R5589:Myo9a
|
UTSW |
9 |
59,802,527 (GRCm39) |
nonsense |
probably null |
|
|
R5607:Myo9a
|
UTSW |
9 |
59,771,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5633:Myo9a
|
UTSW |
9 |
59,775,467 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5885:Myo9a
|
UTSW |
9 |
59,778,503 (GRCm39) |
missense |
probably benign |
|
|
R6024:Myo9a
|
UTSW |
9 |
59,762,671 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6086:Myo9a
|
UTSW |
9 |
59,697,340 (GRCm39) |
nonsense |
probably null |
|
|
R6146:Myo9a
|
UTSW |
9 |
59,778,512 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6194:Myo9a
|
UTSW |
9 |
59,777,033 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6213:Myo9a
|
UTSW |
9 |
59,734,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Myo9a
|
UTSW |
9 |
59,832,231 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6550:Myo9a
|
UTSW |
9 |
59,775,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Myo9a
|
UTSW |
9 |
59,734,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Myo9a
|
UTSW |
9 |
59,779,155 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6951:Myo9a
|
UTSW |
9 |
59,802,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Myo9a
|
UTSW |
9 |
59,722,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Myo9a
|
UTSW |
9 |
59,778,098 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7310:Myo9a
|
UTSW |
9 |
59,778,436 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7473:Myo9a
|
UTSW |
9 |
59,802,527 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7723:Myo9a
|
UTSW |
9 |
59,687,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7823:Myo9a
|
UTSW |
9 |
59,719,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7824:Myo9a
|
UTSW |
9 |
59,767,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Myo9a
|
UTSW |
9 |
59,695,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8031:Myo9a
|
UTSW |
9 |
59,687,374 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8055:Myo9a
|
UTSW |
9 |
59,814,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Myo9a
|
UTSW |
9 |
59,781,931 (GRCm39) |
missense |
probably benign |
|
|
R8250:Myo9a
|
UTSW |
9 |
59,767,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Myo9a
|
UTSW |
9 |
59,817,961 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8355:Myo9a
|
UTSW |
9 |
59,817,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8432:Myo9a
|
UTSW |
9 |
59,687,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Myo9a
|
UTSW |
9 |
59,739,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8528:Myo9a
|
UTSW |
9 |
59,767,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8681:Myo9a
|
UTSW |
9 |
59,775,394 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8690:Myo9a
|
UTSW |
9 |
59,782,657 (GRCm39) |
missense |
probably benign |
|
|
R8793:Myo9a
|
UTSW |
9 |
59,791,850 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8812:Myo9a
|
UTSW |
9 |
59,687,030 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9016:Myo9a
|
UTSW |
9 |
59,775,427 (GRCm39) |
nonsense |
probably null |
|
|
R9026:Myo9a
|
UTSW |
9 |
59,716,757 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9036:Myo9a
|
UTSW |
9 |
59,687,584 (GRCm39) |
nonsense |
probably null |
|
|
R9130:Myo9a
|
UTSW |
9 |
59,739,514 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9131:Myo9a
|
UTSW |
9 |
59,768,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9213:Myo9a
|
UTSW |
9 |
59,772,922 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9498:Myo9a
|
UTSW |
9 |
59,734,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Myo9a
|
UTSW |
9 |
59,813,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9651:Myo9a
|
UTSW |
9 |
59,778,764 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9672:Myo9a
|
UTSW |
9 |
59,687,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
RF018:Myo9a
|
UTSW |
9 |
59,776,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF019:Myo9a
|
UTSW |
9 |
59,829,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Myo9a
|
UTSW |
9 |
59,802,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGCTTTCCTGCTTTTCATCATCACC -3'
(R):5'- GTCTACCTATGCAACATCATGTAATGAAGCTA -3'
Sequencing Primer
(F):5'- CATGGTGGGACAGTAAGAGATG -3'
(R):5'- catacacacacacacacacac -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation