|Institutional Source||Beutler Lab|
|Gene Name||galanin-like peptide|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3713 (G1)|
|Chromosomal Location||6197090-6216137 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 6213837 bp|
|Amino Acid Change||Aspartic acid to Valine at position 72 (D72V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000037408 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000037553]|
|Predicted Effect||probably damaging
AA Change: D72V
PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
AA Change: D72V
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.2733|
|Coding Region Coverage||
|Validation Efficiency||100% (67/67)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Galp||
(F):5'- GAGCCTTTGCATCTATCTATGTATCT -3'
(R):5'- CCCAAAGAAACATATAGAGCCATGGA -3'
(F):5'- ctcagttcaccagtcttg -3'
(R):5'- GATGCACTCCTGAATGCTGTGAAC -3'