Incidental Mutation 'R3713:Zfp108'
ID 259739
Institutional Source Beutler Lab
Gene Symbol Zfp108
Ensembl Gene ENSMUSG00000030486
Gene Name zinc finger protein 108
Synonyms
MMRRC Submission 040706-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R3713 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 23954219-23961870 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 23961270 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 620 (C620*)
Ref Sequence ENSEMBL: ENSMUSP00000145928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072713] [ENSMUST00000205982] [ENSMUST00000206777]
AlphaFold E9Q8I5
Predicted Effect probably null
Transcript: ENSMUST00000072713
AA Change: C620*
SMART Domains Protein: ENSMUSP00000072496
Gene: ENSMUSG00000030486
AA Change: C620*

DomainStartEndE-ValueType
KRAB 8 63 7.94e-18 SMART
low complexity region 140 153 N/A INTRINSIC
ZnF_C2H2 281 303 1.33e-1 SMART
ZnF_C2H2 309 331 1.69e-3 SMART
ZnF_C2H2 337 359 1.3e-4 SMART
ZnF_C2H2 365 387 2.71e-2 SMART
ZnF_C2H2 393 415 5.14e-3 SMART
ZnF_C2H2 421 443 1.87e-5 SMART
ZnF_C2H2 449 471 3.44e-4 SMART
ZnF_C2H2 477 497 1.08e1 SMART
ZnF_C2H2 503 525 3.89e-3 SMART
ZnF_C2H2 531 553 2.09e-3 SMART
ZnF_C2H2 559 581 4.61e-5 SMART
ZnF_C2H2 587 609 7.9e-4 SMART
ZnF_C2H2 615 637 1.67e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000205982
AA Change: C620*
Predicted Effect probably null
Transcript: ENSMUST00000206777
AA Change: C620*
Meta Mutation Damage Score 0.9706 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (67/67)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik T C 16: 88,424,081 (GRCm39) M137V probably benign Het
Aak1 T A 6: 86,932,172 (GRCm39) I381N probably benign Het
Abcd4 C T 12: 84,658,533 (GRCm39) M223I probably benign Het
Adgrf2 A G 17: 43,023,979 (GRCm39) V164A probably damaging Het
Ahdc1 G A 4: 132,793,297 (GRCm39) A1513T possibly damaging Het
Akap13 T C 7: 75,235,929 (GRCm39) M168T probably damaging Het
Aox1 C T 1: 58,095,374 (GRCm39) T196I probably benign Het
Aqr A G 2: 113,949,150 (GRCm39) probably benign Het
Astn1 A G 1: 158,495,102 (GRCm39) E1042G possibly damaging Het
Azi2 A G 9: 117,876,508 (GRCm39) D8G possibly damaging Het
Bcam T C 7: 19,498,118 (GRCm39) T302A probably benign Het
Cct6b A T 11: 82,651,183 (GRCm39) I110N probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Ceacam5 G A 7: 17,493,263 (GRCm39) S762N possibly damaging Het
Cecr2 T C 6: 120,735,221 (GRCm39) L819P probably damaging Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Chd2 A G 7: 73,121,538 (GRCm39) probably benign Het
Col7a1 G T 9: 108,793,508 (GRCm39) G1357* probably null Het
Cux1 A G 5: 136,594,397 (GRCm39) probably benign Het
Cwh43 A T 5: 73,595,835 (GRCm39) I535F probably damaging Het
Dexi A T 16: 10,360,553 (GRCm39) M1K probably null Het
Dnah12 T C 14: 26,534,747 (GRCm39) V2081A probably benign Het
Efcab5 A T 11: 77,007,008 (GRCm39) L872Q probably damaging Het
Enpp7 A G 11: 118,881,344 (GRCm39) Y163C probably damaging Het
Fam221a T C 6: 49,349,548 (GRCm39) Y38H probably damaging Het
Foxred1 A G 9: 35,122,186 (GRCm39) M1T probably null Het
Fscn3 C T 6: 28,428,091 (GRCm39) T26I possibly damaging Het
Galp A T 7: 6,216,836 (GRCm39) D72V probably damaging Het
Gm9843 A G 16: 76,200,419 (GRCm39) noncoding transcript Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Lmbrd1 T C 1: 24,732,076 (GRCm39) Y98H probably damaging Het
Lrrc63 T G 14: 75,344,776 (GRCm39) Y437S probably benign Het
Macc1 A G 12: 119,410,576 (GRCm39) E448G probably benign Het
Madcam1 A G 10: 79,504,194 (GRCm39) H404R probably benign Het
Mink1 G T 11: 70,499,776 (GRCm39) R773L possibly damaging Het
Mroh2b A G 15: 4,973,131 (GRCm39) I1045V probably benign Het
Mroh3 T C 1: 136,113,714 (GRCm39) T692A probably benign Het
Myo15a A T 11: 60,370,057 (GRCm39) E939V possibly damaging Het
Naip2 A G 13: 100,298,410 (GRCm39) F542S probably damaging Het
Napsa A G 7: 44,230,852 (GRCm39) Y73C probably damaging Het
Ndst4 A T 3: 125,355,154 (GRCm39) H354L possibly damaging Het
Neil1 A T 9: 57,054,254 (GRCm39) V22E probably damaging Het
Nol4 T C 18: 23,172,994 (GRCm39) I36V probably damaging Het
Nprl3 G A 11: 32,205,464 (GRCm39) T111I probably damaging Het
Or12k8 A G 2: 36,975,517 (GRCm39) M81T possibly damaging Het
Or1e26 A T 11: 73,479,731 (GRCm39) Y278N probably damaging Het
Or4p22 C A 2: 88,317,787 (GRCm39) T237N probably damaging Het
Pald1 G A 10: 61,178,144 (GRCm39) T624I possibly damaging Het
Pcdhb13 C T 18: 37,576,786 (GRCm39) P388L probably damaging Het
Pcdhga6 T C 18: 37,840,976 (GRCm39) V232A probably damaging Het
Pde6b A G 5: 108,570,928 (GRCm39) I388V probably damaging Het
Phactr2 C A 10: 13,264,476 (GRCm39) probably benign Het
Prdx5 T C 19: 6,885,477 (GRCm39) D56G probably damaging Het
Ptprh A T 7: 4,574,969 (GRCm39) I350N probably damaging Het
Rangap1 C A 15: 81,594,661 (GRCm39) E389D probably benign Het
Reln A G 5: 22,109,732 (GRCm39) V3126A probably damaging Het
Rpl21 G A 5: 146,771,847 (GRCm39) G59S possibly damaging Het
Rsph6a G A 7: 18,791,475 (GRCm39) V215M probably damaging Het
Smcp T C 3: 92,491,431 (GRCm39) K139E unknown Het
Stag1 A G 9: 100,771,671 (GRCm39) T699A probably benign Het
Tars3 G A 7: 65,338,700 (GRCm39) probably null Het
Tle1 G T 4: 72,044,659 (GRCm39) H459Q possibly damaging Het
Ttn G A 2: 76,561,363 (GRCm39) P27302S probably damaging Het
Ttn C T 2: 76,571,610 (GRCm39) V26428I probably damaging Het
Usp53 T C 3: 122,742,968 (GRCm39) E656G probably benign Het
Vmn1r218 A T 13: 23,321,081 (GRCm39) N63Y probably damaging Het
Vmn1r79 A G 7: 11,910,139 (GRCm39) N40S possibly damaging Het
Wdr35 A G 12: 9,077,648 (GRCm39) D1107G possibly damaging Het
Zfp101 A G 17: 33,600,880 (GRCm39) M292T probably benign Het
Zscan4b T C 7: 10,635,818 (GRCm39) T170A probably benign Het
Other mutations in Zfp108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00591:Zfp108 APN 7 23,960,911 (GRCm39) missense possibly damaging 0.82
IGL01392:Zfp108 APN 7 23,957,872 (GRCm39) splice site probably benign
R0123:Zfp108 UTSW 7 23,959,892 (GRCm39) missense probably benign 0.00
R0126:Zfp108 UTSW 7 23,960,149 (GRCm39) missense probably benign 0.01
R0134:Zfp108 UTSW 7 23,959,892 (GRCm39) missense probably benign 0.00
R0243:Zfp108 UTSW 7 23,961,208 (GRCm39) missense possibly damaging 0.81
R1227:Zfp108 UTSW 7 23,959,885 (GRCm39) missense probably benign 0.00
R1464:Zfp108 UTSW 7 23,959,973 (GRCm39) missense probably benign 0.00
R1464:Zfp108 UTSW 7 23,959,973 (GRCm39) missense probably benign 0.00
R1731:Zfp108 UTSW 7 23,957,964 (GRCm39) missense possibly damaging 0.75
R1739:Zfp108 UTSW 7 23,960,735 (GRCm39) missense probably damaging 1.00
R1751:Zfp108 UTSW 7 23,961,321 (GRCm39) missense probably damaging 1.00
R3839:Zfp108 UTSW 7 23,959,981 (GRCm39) missense probably benign 0.01
R3919:Zfp108 UTSW 7 23,960,257 (GRCm39) missense probably damaging 0.99
R3922:Zfp108 UTSW 7 23,960,773 (GRCm39) missense probably damaging 1.00
R4707:Zfp108 UTSW 7 23,959,837 (GRCm39) missense probably benign 0.08
R4912:Zfp108 UTSW 7 23,960,739 (GRCm39) missense probably damaging 1.00
R4965:Zfp108 UTSW 7 23,959,573 (GRCm39) missense probably benign
R4989:Zfp108 UTSW 7 23,960,163 (GRCm39) missense probably benign 0.00
R5014:Zfp108 UTSW 7 23,960,163 (GRCm39) missense probably benign 0.00
R5163:Zfp108 UTSW 7 23,960,163 (GRCm39) missense probably benign 0.00
R5183:Zfp108 UTSW 7 23,960,163 (GRCm39) missense probably benign 0.00
R5184:Zfp108 UTSW 7 23,960,163 (GRCm39) missense probably benign 0.00
R5185:Zfp108 UTSW 7 23,960,163 (GRCm39) missense probably benign 0.00
R5453:Zfp108 UTSW 7 23,960,689 (GRCm39) missense probably damaging 1.00
R5600:Zfp108 UTSW 7 23,960,011 (GRCm39) missense probably benign 0.00
R6494:Zfp108 UTSW 7 23,960,782 (GRCm39) missense probably damaging 1.00
R6601:Zfp108 UTSW 7 23,960,819 (GRCm39) missense probably damaging 0.98
R6735:Zfp108 UTSW 7 23,961,197 (GRCm39) missense probably damaging 1.00
R7646:Zfp108 UTSW 7 23,960,840 (GRCm39) missense probably damaging 1.00
R7732:Zfp108 UTSW 7 23,960,952 (GRCm39) missense probably benign 0.00
R7873:Zfp108 UTSW 7 23,960,758 (GRCm39) missense probably benign 0.19
R8100:Zfp108 UTSW 7 23,960,602 (GRCm39) missense probably damaging 1.00
R8313:Zfp108 UTSW 7 23,960,087 (GRCm39) missense possibly damaging 0.80
R9169:Zfp108 UTSW 7 23,960,923 (GRCm39) missense probably damaging 1.00
R9702:Zfp108 UTSW 7 23,960,195 (GRCm39) missense probably benign 0.02
RF019:Zfp108 UTSW 7 23,961,032 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GTTCCGTCAGGCCTCAATCC -3'
(R):5'- GAGTCCACCTGAGTGCAGAAC -3'

Sequencing Primer
(F):5'- CCCTACAAATGTGACACGTGTGG -3'
(R):5'- CCTGAGTGCAGAACAAACCTAGG -3'
Posted On 2015-01-23