Incidental Mutation 'R3715:Or4c15'
ID 259833
Institutional Source Beutler Lab
Gene Symbol Or4c15
Ensembl Gene ENSMUSG00000075112
Gene Name olfactory receptor family 4 subfamily C member 15
Synonyms MOR233-16P, MOR233-21, GA_x6K02T2Q125-50409367-50408432, Olfr1211
MMRRC Submission 040708-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R3715 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88759722-88764870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88759757 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 301 (W301R)
Ref Sequence ENSEMBL: ENSMUSP00000150571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]
AlphaFold Q7TR09
Predicted Effect probably benign
Transcript: ENSMUST00000099808
AA Change: W301R

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: W301R

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 9.5e-49 PFAM
Pfam:7tm_1 39 286 2.5e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141958
Predicted Effect probably benign
Transcript: ENSMUST00000213412
AA Change: W301R

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000215205
AA Change: W301R

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.7247 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik T C 16: 88,424,081 (GRCm39) M137V probably benign Het
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Aaas T C 15: 102,248,771 (GRCm39) I236V probably benign Het
Abcd4 C T 12: 84,658,533 (GRCm39) M223I probably benign Het
Adamtsl1 T A 4: 86,135,213 (GRCm39) I246N probably benign Het
Ak9 A G 10: 41,233,508 (GRCm39) D582G probably damaging Het
Aqr A G 2: 113,949,150 (GRCm39) probably benign Het
Bmal2 A G 6: 146,724,187 (GRCm39) K360E probably damaging Het
Cacna2d3 T C 14: 29,068,880 (GRCm39) I282M probably damaging Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Dexi A T 16: 10,360,553 (GRCm39) M1K probably null Het
Dlat A G 9: 50,549,354 (GRCm39) V510A probably damaging Het
Eaf1 T C 14: 31,224,402 (GRCm39) I173T possibly damaging Het
Elavl3 G T 9: 21,929,895 (GRCm39) D336E probably benign Het
Epm2a A G 10: 11,219,420 (GRCm39) Y69C probably benign Het
Fam168a A G 7: 100,473,432 (GRCm39) N107S probably damaging Het
Fam43b G C 4: 138,122,409 (GRCm39) R304G probably benign Het
Fras1 T C 5: 96,793,829 (GRCm39) probably null Het
Fscn3 C T 6: 28,428,091 (GRCm39) T26I possibly damaging Het
Glt8d2 C A 10: 82,488,571 (GRCm39) A300S probably benign Het
Hcn4 G A 9: 58,751,319 (GRCm39) R315H unknown Het
Lipk A G 19: 34,017,829 (GRCm39) N289S probably damaging Het
Lyg1 G T 1: 37,989,759 (GRCm39) R43S probably damaging Het
Marchf6 A G 15: 31,465,405 (GRCm39) L833P probably benign Het
Mc4r T A 18: 66,992,892 (GRCm39) N74Y probably damaging Het
Med17 G A 9: 15,175,062 (GRCm39) probably benign Het
Mink1 G T 11: 70,499,776 (GRCm39) R773L possibly damaging Het
Myo15a A T 11: 60,370,057 (GRCm39) E939V possibly damaging Het
Ndst4 A T 3: 125,355,154 (GRCm39) H354L possibly damaging Het
Or2t26 T C 11: 49,039,642 (GRCm39) L186P probably damaging Het
Or4p22 C A 2: 88,317,787 (GRCm39) T237N probably damaging Het
Otof T A 5: 30,534,215 (GRCm39) K1397* probably null Het
Rangap1 C A 15: 81,594,661 (GRCm39) E389D probably benign Het
Rbfox2 A G 15: 76,983,451 (GRCm39) I270T probably damaging Het
Rnf217 G T 10: 31,410,728 (GRCm39) C322* probably null Het
Sbk1 A G 7: 125,889,183 (GRCm39) T50A probably benign Het
Shmt1 T C 11: 60,688,402 (GRCm39) T248A probably damaging Het
Smim29 G A 17: 27,785,043 (GRCm39) probably benign Het
Sox30 C T 11: 45,875,619 (GRCm39) T457I probably damaging Het
Stox2 T A 8: 47,866,187 (GRCm39) I52F possibly damaging Het
Syncrip A T 9: 88,361,738 (GRCm39) probably benign Het
Tars3 G A 7: 65,338,700 (GRCm39) probably null Het
Tdrd12 T C 7: 35,204,405 (GRCm39) E235G probably benign Het
Tmem82 A T 4: 141,344,945 (GRCm39) probably null Het
Tro T C X: 149,437,230 (GRCm39) T476A probably damaging Het
Ttn G A 2: 76,561,363 (GRCm39) P27302S probably damaging Het
Ttn C T 2: 76,571,610 (GRCm39) V26428I probably damaging Het
Usp53 T C 3: 122,742,968 (GRCm39) E656G probably benign Het
Vmn2r100 A G 17: 19,752,272 (GRCm39) R772G probably damaging Het
Xkr5 T C 8: 18,984,474 (GRCm39) E190G probably benign Het
Zfp236 A G 18: 82,651,095 (GRCm39) probably benign Het
Zfr2 T G 10: 81,081,913 (GRCm39) V493G probably benign Het
Zp2 A T 7: 119,741,057 (GRCm39) S156T possibly damaging Het
Zswim5 A G 4: 116,819,755 (GRCm39) T387A probably benign Het
Other mutations in Or4c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02724:Or4c15 APN 2 88,759,792 (GRCm39) missense probably damaging 1.00
IGL02936:Or4c15 APN 2 88,760,128 (GRCm39) missense probably benign 0.01
IGL02960:Or4c15 APN 2 88,760,128 (GRCm39) missense possibly damaging 0.80
IGL02989:Or4c15 APN 2 88,760,048 (GRCm39) missense possibly damaging 0.72
R0193:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R0413:Or4c15 UTSW 2 88,759,906 (GRCm39) missense probably benign 0.16
R1644:Or4c15 UTSW 2 88,759,731 (GRCm39) missense probably benign 0.01
R4019:Or4c15 UTSW 2 88,760,080 (GRCm39) missense probably benign 0.02
R4722:Or4c15 UTSW 2 88,760,324 (GRCm39) missense possibly damaging 0.91
R4751:Or4c15 UTSW 2 88,760,258 (GRCm39) missense probably damaging 1.00
R4859:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R5053:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.02
R6148:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.00
R7064:Or4c15 UTSW 2 88,759,853 (GRCm39) missense probably benign 0.00
R7527:Or4c15 UTSW 2 88,760,434 (GRCm39) missense probably benign 0.00
R7584:Or4c15 UTSW 2 88,760,149 (GRCm39) missense probably damaging 1.00
R7989:Or4c15 UTSW 2 88,759,858 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGTTGCCAGCTAAGAATTGATACTC -3'
(R):5'- TGGAAAGCTCTCTCCACATG -3'

Sequencing Primer
(F):5'- GATGGTTTGCTAGTGCCA -3'
(R):5'- TGGATCCCACATTGCAGTTG -3'
Posted On 2015-01-23