Incidental Mutation 'R3715:Or2t26'
ID 259865
Institutional Source Beutler Lab
Gene Symbol Or2t26
Ensembl Gene ENSMUSG00000050763
Gene Name olfactory receptor family 2 subfamily T member 26
Synonyms GA_x6K02T2QP88-6286247-6285294, Olfr1395, MOR277-1
MMRRC Submission 040708-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R3715 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49039086-49040039 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49039642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 186 (L186P)
Ref Sequence ENSEMBL: ENSMUSP00000150679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059379] [ENSMUST00000203377] [ENSMUST00000214195]
AlphaFold Q8VGD7
Predicted Effect probably damaging
Transcript: ENSMUST00000059379
AA Change: L186P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000050142
Gene: ENSMUSG00000050763
AA Change: L186P

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 1e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 252 4.8e-6 PFAM
Pfam:7tm_1 42 291 1.9e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203377
AA Change: L186P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145357
Gene: ENSMUSG00000050763
AA Change: L186P

DomainStartEndE-ValueType
Pfam:7tm_1 1 219 1.9e-18 PFAM
Pfam:7tm_4 1 237 2.4e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214195
AA Change: L186P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik T C 16: 88,424,081 (GRCm39) M137V probably benign Het
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Aaas T C 15: 102,248,771 (GRCm39) I236V probably benign Het
Abcd4 C T 12: 84,658,533 (GRCm39) M223I probably benign Het
Adamtsl1 T A 4: 86,135,213 (GRCm39) I246N probably benign Het
Ak9 A G 10: 41,233,508 (GRCm39) D582G probably damaging Het
Aqr A G 2: 113,949,150 (GRCm39) probably benign Het
Bmal2 A G 6: 146,724,187 (GRCm39) K360E probably damaging Het
Cacna2d3 T C 14: 29,068,880 (GRCm39) I282M probably damaging Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Dexi A T 16: 10,360,553 (GRCm39) M1K probably null Het
Dlat A G 9: 50,549,354 (GRCm39) V510A probably damaging Het
Eaf1 T C 14: 31,224,402 (GRCm39) I173T possibly damaging Het
Elavl3 G T 9: 21,929,895 (GRCm39) D336E probably benign Het
Epm2a A G 10: 11,219,420 (GRCm39) Y69C probably benign Het
Fam168a A G 7: 100,473,432 (GRCm39) N107S probably damaging Het
Fam43b G C 4: 138,122,409 (GRCm39) R304G probably benign Het
Fras1 T C 5: 96,793,829 (GRCm39) probably null Het
Fscn3 C T 6: 28,428,091 (GRCm39) T26I possibly damaging Het
Glt8d2 C A 10: 82,488,571 (GRCm39) A300S probably benign Het
Hcn4 G A 9: 58,751,319 (GRCm39) R315H unknown Het
Lipk A G 19: 34,017,829 (GRCm39) N289S probably damaging Het
Lyg1 G T 1: 37,989,759 (GRCm39) R43S probably damaging Het
Marchf6 A G 15: 31,465,405 (GRCm39) L833P probably benign Het
Mc4r T A 18: 66,992,892 (GRCm39) N74Y probably damaging Het
Med17 G A 9: 15,175,062 (GRCm39) probably benign Het
Mink1 G T 11: 70,499,776 (GRCm39) R773L possibly damaging Het
Myo15a A T 11: 60,370,057 (GRCm39) E939V possibly damaging Het
Ndst4 A T 3: 125,355,154 (GRCm39) H354L possibly damaging Het
Or4c15 A G 2: 88,759,757 (GRCm39) W301R probably benign Het
Or4p22 C A 2: 88,317,787 (GRCm39) T237N probably damaging Het
Otof T A 5: 30,534,215 (GRCm39) K1397* probably null Het
Rangap1 C A 15: 81,594,661 (GRCm39) E389D probably benign Het
Rbfox2 A G 15: 76,983,451 (GRCm39) I270T probably damaging Het
Rnf217 G T 10: 31,410,728 (GRCm39) C322* probably null Het
Sbk1 A G 7: 125,889,183 (GRCm39) T50A probably benign Het
Shmt1 T C 11: 60,688,402 (GRCm39) T248A probably damaging Het
Smim29 G A 17: 27,785,043 (GRCm39) probably benign Het
Sox30 C T 11: 45,875,619 (GRCm39) T457I probably damaging Het
Stox2 T A 8: 47,866,187 (GRCm39) I52F possibly damaging Het
Syncrip A T 9: 88,361,738 (GRCm39) probably benign Het
Tars3 G A 7: 65,338,700 (GRCm39) probably null Het
Tdrd12 T C 7: 35,204,405 (GRCm39) E235G probably benign Het
Tmem82 A T 4: 141,344,945 (GRCm39) probably null Het
Tro T C X: 149,437,230 (GRCm39) T476A probably damaging Het
Ttn G A 2: 76,561,363 (GRCm39) P27302S probably damaging Het
Ttn C T 2: 76,571,610 (GRCm39) V26428I probably damaging Het
Usp53 T C 3: 122,742,968 (GRCm39) E656G probably benign Het
Vmn2r100 A G 17: 19,752,272 (GRCm39) R772G probably damaging Het
Xkr5 T C 8: 18,984,474 (GRCm39) E190G probably benign Het
Zfp236 A G 18: 82,651,095 (GRCm39) probably benign Het
Zfr2 T G 10: 81,081,913 (GRCm39) V493G probably benign Het
Zp2 A T 7: 119,741,057 (GRCm39) S156T possibly damaging Het
Zswim5 A G 4: 116,819,755 (GRCm39) T387A probably benign Het
Other mutations in Or2t26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02413:Or2t26 APN 11 49,039,384 (GRCm39) missense probably damaging 1.00
IGL02946:Or2t26 APN 11 49,039,719 (GRCm39) missense probably damaging 1.00
R0030:Or2t26 UTSW 11 49,039,867 (GRCm39) missense possibly damaging 0.81
R1013:Or2t26 UTSW 11 49,039,977 (GRCm39) missense probably damaging 1.00
R1577:Or2t26 UTSW 11 49,040,016 (GRCm39) missense probably benign 0.05
R1908:Or2t26 UTSW 11 49,039,101 (GRCm39) missense possibly damaging 0.95
R4386:Or2t26 UTSW 11 49,039,842 (GRCm39) missense probably damaging 1.00
R4496:Or2t26 UTSW 11 49,039,214 (GRCm39) missense possibly damaging 0.86
R5030:Or2t26 UTSW 11 49,039,188 (GRCm39) missense probably benign 0.01
R6044:Or2t26 UTSW 11 49,039,522 (GRCm39) missense probably benign 0.29
R6226:Or2t26 UTSW 11 49,039,660 (GRCm39) missense possibly damaging 0.81
R7177:Or2t26 UTSW 11 49,040,012 (GRCm39) nonsense probably null
R7282:Or2t26 UTSW 11 49,039,945 (GRCm39) missense probably damaging 1.00
R7391:Or2t26 UTSW 11 49,039,806 (GRCm39) missense probably damaging 1.00
R7411:Or2t26 UTSW 11 49,039,821 (GRCm39) missense probably benign 0.01
R7888:Or2t26 UTSW 11 49,039,266 (GRCm39) missense probably damaging 1.00
R8869:Or2t26 UTSW 11 49,039,483 (GRCm39) missense probably damaging 1.00
R8944:Or2t26 UTSW 11 49,039,266 (GRCm39) missense probably damaging 1.00
R9048:Or2t26 UTSW 11 49,039,830 (GRCm39) missense probably damaging 1.00
R9253:Or2t26 UTSW 11 49,039,822 (GRCm39) missense probably damaging 0.98
R9445:Or2t26 UTSW 11 49,039,879 (GRCm39) missense probably benign 0.25
R9752:Or2t26 UTSW 11 49,039,681 (GRCm39) missense probably benign 0.27
Predicted Primers PCR Primer
(F):5'- CAACCCGCTGAGATACTCTG -3'
(R):5'- TCATGTATGTGATCATGGCAGCC -3'

Sequencing Primer
(F):5'- GAGATACTCTGTAATCATGAGCCGC -3'
(R):5'- ATCATGGCAGCCCCGTAGAAG -3'
Posted On 2015-01-23