Incidental Mutation 'R2878:Fscb'
ID 260186
Institutional Source Beutler Lab
Gene Symbol Fscb
Ensembl Gene ENSMUSG00000043060
Gene Name fibrous sheath CABYR binding protein
Synonyms EG623046
MMRRC Submission 040466-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R2878 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 64518104-64521464 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 64519348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 706 (V706E)
Ref Sequence ENSEMBL: ENSMUSP00000051554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059833]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000059833
AA Change: V706E
SMART Domains Protein: ENSMUSP00000051554
Gene: ENSMUSG00000043060
AA Change: V706E

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
low complexity region 273 290 N/A INTRINSIC
internal_repeat_1 295 465 2.4e-7 PROSPERO
low complexity region 483 501 N/A INTRINSIC
low complexity region 510 547 N/A INTRINSIC
low complexity region 558 595 N/A INTRINSIC
low complexity region 599 622 N/A INTRINSIC
low complexity region 641 661 N/A INTRINSIC
low complexity region 673 708 N/A INTRINSIC
low complexity region 721 730 N/A INTRINSIC
internal_repeat_1 736 895 2.4e-7 PROSPERO
internal_repeat_2 751 871 6.17e-6 PROSPERO
low complexity region 899 916 N/A INTRINSIC
internal_repeat_2 919 1046 6.17e-6 PROSPERO
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 92% (58/63)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,241,889 (GRCm39) L1251F possibly damaging Het
Accsl A T 2: 93,689,755 (GRCm39) M384K probably damaging Het
Adgrg7 A G 16: 56,570,817 (GRCm39) F404L probably benign Het
Akr1c20 G A 13: 4,557,774 (GRCm39) T251M probably damaging Het
Amph G A 13: 19,288,437 (GRCm39) V309I possibly damaging Het
Ano2 T G 6: 125,840,481 (GRCm39) F384C probably damaging Het
Aplf G A 6: 87,645,409 (GRCm39) R32* probably null Het
Arhgef18 A G 8: 3,482,759 (GRCm39) M155V probably benign Het
Atg2b A T 12: 105,630,268 (GRCm39) Y374* probably null Het
Camkmt T C 17: 85,738,979 (GRCm39) probably benign Het
Capn2 T A 1: 182,344,798 (GRCm39) E41V probably benign Het
Cd53 T C 3: 106,674,732 (GRCm39) T112A probably benign Het
Cyp2a4 G A 7: 26,011,612 (GRCm39) E278K possibly damaging Het
Dact2 A T 17: 14,416,176 (GRCm39) S675T probably damaging Het
Dync1li2 A C 8: 105,156,047 (GRCm39) Y265D probably damaging Het
Eml4 T A 17: 83,717,603 (GRCm39) H58Q probably benign Het
F13b T C 1: 139,429,485 (GRCm39) M1T probably null Het
Fam83b A G 9: 76,398,092 (GRCm39) F1004L probably damaging Het
Fbxo48 A G 11: 16,903,382 (GRCm39) K3E possibly damaging Het
Fbxw13 A G 9: 109,010,534 (GRCm39) F368S probably damaging Het
Fbxw19 A T 9: 109,315,038 (GRCm39) W175R probably damaging Het
Fibcd1 G A 2: 31,728,678 (GRCm39) P60S probably benign Het
Gfm2 A G 13: 97,289,757 (GRCm39) R181G possibly damaging Het
Gm17546 A T 15: 95,727,805 (GRCm39) probably benign Het
Grin1 A G 2: 25,187,641 (GRCm39) V594A probably damaging Het
Itpripl1 A G 2: 126,983,534 (GRCm39) V196A probably benign Het
Kcns1 A G 2: 164,006,682 (GRCm39) I427T probably damaging Het
Map3k19 T A 1: 127,751,530 (GRCm39) E607V possibly damaging Het
Map3k4 T C 17: 12,482,954 (GRCm39) S588G probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Naa80 A T 9: 107,460,367 (GRCm39) E87D possibly damaging Het
Nebl C A 2: 17,439,740 (GRCm39) D178Y probably damaging Het
Nfatc3 C A 8: 106,818,776 (GRCm39) T498K probably damaging Het
Nfkb2 G A 19: 46,295,880 (GRCm39) R158H possibly damaging Het
Obscn T C 11: 58,947,014 (GRCm39) E4337G possibly damaging Het
Or5b106 A G 19: 13,123,771 (GRCm39) L84P probably benign Het
Palb2 A G 7: 121,713,652 (GRCm39) V877A probably damaging Het
Rbm6 T C 9: 107,729,649 (GRCm39) E333G probably damaging Het
Rem2 A G 14: 54,713,819 (GRCm39) T31A possibly damaging Het
Ric1 A G 19: 29,579,730 (GRCm39) D1224G possibly damaging Het
Rp1 A G 1: 4,418,362 (GRCm39) S917P probably damaging Het
Scn2a G A 2: 65,518,715 (GRCm39) G363D probably damaging Het
Shcbp1l A T 1: 153,313,264 (GRCm39) probably benign Het
Skor2 G T 18: 76,948,419 (GRCm39) E714* probably null Het
Slc15a1 T A 14: 121,703,345 (GRCm39) K545N probably benign Het
Slc1a2 T A 2: 102,591,512 (GRCm39) M414K probably damaging Het
Slc7a8 A G 14: 54,997,143 (GRCm39) S70P probably damaging Het
Spopfm1 G T 3: 94,173,787 (GRCm39) C265F possibly damaging Het
Taf1a A G 1: 183,179,173 (GRCm39) E117G probably damaging Het
Trem2 A G 17: 48,658,141 (GRCm39) D135G probably benign Het
Ttn T C 2: 76,567,409 (GRCm39) D27828G probably damaging Het
Ulk4 T C 9: 121,089,105 (GRCm39) D258G probably benign Het
Unc80 TGTATTCCAGGCG TG 1: 66,710,735 (GRCm39) probably benign Het
Vmn2r56 A C 7: 12,444,954 (GRCm39) M433R probably benign Het
Wdr45 C T X: 7,593,611 (GRCm39) P271S probably damaging Het
Zfp410 A C 12: 84,378,411 (GRCm39) N245T probably damaging Het
Other mutations in Fscb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01095:Fscb APN 12 64,520,155 (GRCm39) missense possibly damaging 0.46
IGL01099:Fscb APN 12 64,518,875 (GRCm39) missense unknown
IGL01394:Fscb APN 12 64,520,578 (GRCm39) missense possibly damaging 0.83
IGL02570:Fscb APN 12 64,518,952 (GRCm39) missense unknown
IGL02974:Fscb APN 12 64,518,299 (GRCm39) missense unknown
IGL03150:Fscb APN 12 64,519,204 (GRCm39) missense unknown
IGL03407:Fscb APN 12 64,520,269 (GRCm39) missense probably damaging 0.96
BB007:Fscb UTSW 12 64,519,337 (GRCm39) missense unknown
BB017:Fscb UTSW 12 64,519,337 (GRCm39) missense unknown
FR4548:Fscb UTSW 12 64,519,339 (GRCm39) missense unknown
FR4548:Fscb UTSW 12 64,519,337 (GRCm39) missense unknown
R0056:Fscb UTSW 12 64,521,021 (GRCm39) missense possibly damaging 0.66
R0490:Fscb UTSW 12 64,519,661 (GRCm39) missense unknown
R0492:Fscb UTSW 12 64,520,292 (GRCm39) missense possibly damaging 0.46
R0702:Fscb UTSW 12 64,518,775 (GRCm39) missense unknown
R1017:Fscb UTSW 12 64,520,242 (GRCm39) missense probably benign 0.07
R1672:Fscb UTSW 12 64,518,292 (GRCm39) missense unknown
R1737:Fscb UTSW 12 64,521,355 (GRCm39) missense possibly damaging 0.83
R1795:Fscb UTSW 12 64,521,175 (GRCm39) missense probably damaging 0.99
R1969:Fscb UTSW 12 64,520,008 (GRCm39) missense unknown
R1984:Fscb UTSW 12 64,521,457 (GRCm39) missense unknown
R2164:Fscb UTSW 12 64,520,567 (GRCm39) missense probably damaging 0.96
R2213:Fscb UTSW 12 64,520,890 (GRCm39) missense possibly damaging 0.84
R2874:Fscb UTSW 12 64,520,210 (GRCm39) missense probably benign 0.00
R3873:Fscb UTSW 12 64,519,906 (GRCm39) missense unknown
R4734:Fscb UTSW 12 64,521,244 (GRCm39) missense possibly damaging 0.82
R4773:Fscb UTSW 12 64,520,464 (GRCm39) missense probably damaging 1.00
R4940:Fscb UTSW 12 64,520,588 (GRCm39) missense probably benign 0.03
R4981:Fscb UTSW 12 64,520,393 (GRCm39) missense possibly damaging 0.46
R5105:Fscb UTSW 12 64,520,110 (GRCm39) missense possibly damaging 0.82
R5845:Fscb UTSW 12 64,519,558 (GRCm39) missense unknown
R6049:Fscb UTSW 12 64,521,094 (GRCm39) missense possibly damaging 0.66
R6743:Fscb UTSW 12 64,518,347 (GRCm39) missense unknown
R7026:Fscb UTSW 12 64,518,391 (GRCm39) missense unknown
R7285:Fscb UTSW 12 64,518,323 (GRCm39) missense unknown
R7372:Fscb UTSW 12 64,518,598 (GRCm39) missense unknown
R7400:Fscb UTSW 12 64,518,391 (GRCm39) missense unknown
R7563:Fscb UTSW 12 64,520,059 (GRCm39) missense possibly damaging 0.82
R7748:Fscb UTSW 12 64,521,181 (GRCm39) missense probably benign 0.04
R7759:Fscb UTSW 12 64,520,866 (GRCm39) missense probably benign 0.03
R7930:Fscb UTSW 12 64,519,337 (GRCm39) missense unknown
R8026:Fscb UTSW 12 64,521,049 (GRCm39) missense probably benign 0.12
R8070:Fscb UTSW 12 64,521,382 (GRCm39) missense probably benign 0.04
R8081:Fscb UTSW 12 64,518,802 (GRCm39) missense unknown
R8331:Fscb UTSW 12 64,520,242 (GRCm39) missense probably benign 0.07
R8405:Fscb UTSW 12 64,520,278 (GRCm39) missense possibly damaging 0.82
R8788:Fscb UTSW 12 64,518,395 (GRCm39) missense unknown
R8833:Fscb UTSW 12 64,519,997 (GRCm39) missense unknown
R8997:Fscb UTSW 12 64,520,758 (GRCm39) missense possibly damaging 0.46
R9192:Fscb UTSW 12 64,520,890 (GRCm39) missense possibly damaging 0.49
R9282:Fscb UTSW 12 64,520,097 (GRCm39) missense possibly damaging 0.46
R9437:Fscb UTSW 12 64,519,708 (GRCm39) missense unknown
R9581:Fscb UTSW 12 64,521,122 (GRCm39) missense probably benign 0.16
RF011:Fscb UTSW 12 64,519,768 (GRCm39) small deletion probably benign
RF019:Fscb UTSW 12 64,519,370 (GRCm39) small insertion probably benign
RF038:Fscb UTSW 12 64,519,343 (GRCm39) small insertion probably benign
Z1176:Fscb UTSW 12 64,519,704 (GRCm39) missense unknown
Z1177:Fscb UTSW 12 64,519,402 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACTTGTGCAGAGGCTTCTTCAG -3'
(R):5'- GGCTCTGCTGAAGTTTCTCC -3'

Sequencing Primer
(F):5'- TTCAGCAGTGGACTCACCTGATAAAG -3'
(R):5'- GTTTCTCCTCCACAAACTGAAGAGG -3'
Posted On 2015-01-23