|Institutional Source||Beutler Lab|
|Gene Name||solute carrier family 15 (oligopeptide transporter), member 1|
|Is this an essential gene?||Probably non essential (E-score: 0.051)|
|Stock #||R2878 (G1)|
|Chromosomal Location||121459621-121505252 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 121465933 bp|
|Amino Acid Change||Lysine to Asparagine at position 545 (K545N)|
|Ref Sequence||ENSEMBL: ENSMUSP00000085728 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000088386]|
|Predicted Effect||probably benign
AA Change: K545N
PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
AA Change: K545N
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||92% (58/63)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
PHENOTYPE: Peptide uptake in the intestine is substantially reduced in mice homozygous for a null mutation of this gene. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Slc15a1||
(F):5'- AGTTGGGTTAGTTCTAAGACCATC -3'
(R):5'- ACCCTTAACGAGATGGTCACC -3'
(F):5'- GGGTTAGTTCTAAGACCATCTACAG -3'
(R):5'- AGTGAGTACCTTTACTGGGCAAC -3'