Incidental Mutation 'R2879:Wipf2'
ID 260245
Institutional Source Beutler Lab
Gene Symbol Wipf2
Ensembl Gene ENSMUSG00000038013
Gene Name WAS/WASL interacting protein family, member 2
Synonyms 1110014J05Rik, 5730509C05Rik
MMRRC Submission 040467-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.309) question?
Stock # R2879 (G1)
Quality Score 125
Status Not validated
Chromosome 11
Chromosomal Location 98754464-98795866 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 98783480 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 302 (A302V)
Ref Sequence ENSEMBL: ENSMUSP00000046991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037480] [ENSMUST00000142414]
AlphaFold Q6PEV3
Predicted Effect probably benign
Transcript: ENSMUST00000037480
AA Change: A302V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000046991
Gene: ENSMUSG00000038013
AA Change: A302V

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
WH2 36 53 2.81e-4 SMART
low complexity region 69 80 N/A INTRINSIC
low complexity region 116 134 N/A INTRINSIC
low complexity region 173 192 N/A INTRINSIC
low complexity region 225 236 N/A INTRINSIC
low complexity region 250 265 N/A INTRINSIC
low complexity region 288 308 N/A INTRINSIC
low complexity region 310 330 N/A INTRINSIC
low complexity region 353 377 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132006
Predicted Effect probably benign
Transcript: ENSMUST00000142414
SMART Domains Protein: ENSMUSP00000123244
Gene: ENSMUSG00000038013

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
WH2 36 53 2.81e-4 SMART
low complexity region 69 80 N/A INTRINSIC
low complexity region 116 134 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148439
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 G C 17: 24,508,481 (GRCm39) T1018R probably damaging Het
Acte1 T A 7: 143,447,800 (GRCm39) Y214* probably null Het
Akap9 A G 5: 4,026,353 (GRCm39) probably benign Het
Ankrd29 G A 18: 12,387,757 (GRCm39) A275V possibly damaging Het
Ano6 T A 15: 95,841,308 (GRCm39) C468* probably null Het
Arhgef10l G T 4: 140,242,598 (GRCm39) H890Q probably benign Het
Ccnj T A 19: 40,833,158 (GRCm39) L112Q probably damaging Het
Chaf1a T C 17: 56,351,114 (GRCm39) probably null Het
Chchd4 A G 6: 91,442,200 (GRCm39) S73P probably damaging Het
Chd3 T C 11: 69,254,924 (GRCm39) K139E possibly damaging Het
Cyp2b13 T G 7: 25,785,456 (GRCm39) probably null Het
Dagla T C 19: 10,248,448 (GRCm39) I71V possibly damaging Het
Epor A T 9: 21,870,936 (GRCm39) W315R probably damaging Het
Etv1 T A 12: 38,833,809 (GRCm39) probably null Het
Fbn2 A T 18: 58,202,314 (GRCm39) C1280S probably damaging Het
Fbxo2 G C 4: 148,250,468 (GRCm39) R269P probably damaging Het
Fer1l4 A T 2: 155,894,120 (GRCm39) L61Q probably damaging Het
Ggnbp2 C T 11: 84,723,797 (GRCm39) probably null Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Ibsp G A 5: 104,458,260 (GRCm39) E266K possibly damaging Het
Lamb3 T A 1: 193,013,092 (GRCm39) M439K possibly damaging Het
Lnx1 C T 5: 74,780,784 (GRCm39) V246M probably benign Het
Lrrc32 A G 7: 98,148,984 (GRCm39) Q588R probably benign Het
Magi2 A AG 5: 20,807,459 (GRCm39) probably null Het
Med13 C T 11: 86,189,988 (GRCm39) A974T possibly damaging Het
Mogat2 A T 7: 98,871,573 (GRCm39) I246N possibly damaging Het
Myl2 T C 5: 122,242,748 (GRCm39) probably null Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or1p1c T A 11: 74,161,049 (GRCm39) V278D probably damaging Het
Osbpl8 T A 10: 111,105,297 (GRCm39) S251T probably benign Het
Pik3r2 A G 8: 71,225,029 (GRCm39) Y145H probably benign Het
Plg A G 17: 12,622,987 (GRCm39) E509G possibly damaging Het
Pnkp T A 7: 44,508,102 (GRCm39) S142T probably damaging Het
Ros1 C T 10: 52,048,936 (GRCm39) probably null Het
Sbno1 A G 5: 124,526,635 (GRCm39) M960T probably damaging Het
Smad1 T C 8: 80,080,084 (GRCm39) probably null Het
Ssc5d G A 7: 4,939,906 (GRCm39) probably null Het
Tfcp2 C T 15: 100,449,201 (GRCm39) probably null Het
Tmem121 A G 12: 113,152,028 (GRCm39) Y82C probably damaging Het
Tmem131 T C 1: 36,880,788 (GRCm39) I161V possibly damaging Het
Tpp2 T A 1: 44,010,783 (GRCm39) F523L probably damaging Het
Ttn C T 2: 76,601,849 (GRCm39) silent Het
Ttpal A G 2: 163,457,503 (GRCm39) probably null Het
Vdr T A 15: 97,757,008 (GRCm39) Y288F probably benign Het
Zfp346 T G 13: 55,253,163 (GRCm39) C3G possibly damaging Het
Other mutations in Wipf2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01538:Wipf2 APN 11 98,781,629 (GRCm39) missense possibly damaging 0.93
IGL01642:Wipf2 APN 11 98,781,650 (GRCm39) missense probably benign 0.01
IGL03008:Wipf2 APN 11 98,783,554 (GRCm39) unclassified probably benign
R0557:Wipf2 UTSW 11 98,782,915 (GRCm39) missense possibly damaging 0.65
R1054:Wipf2 UTSW 11 98,787,141 (GRCm39) missense possibly damaging 0.91
R1936:Wipf2 UTSW 11 98,783,236 (GRCm39) nonsense probably null
R1937:Wipf2 UTSW 11 98,783,236 (GRCm39) nonsense probably null
R1939:Wipf2 UTSW 11 98,783,236 (GRCm39) nonsense probably null
R1940:Wipf2 UTSW 11 98,783,236 (GRCm39) nonsense probably null
R2143:Wipf2 UTSW 11 98,787,040 (GRCm39) missense possibly damaging 0.94
R2144:Wipf2 UTSW 11 98,787,040 (GRCm39) missense possibly damaging 0.94
R2398:Wipf2 UTSW 11 98,789,543 (GRCm39) splice site probably null
R4775:Wipf2 UTSW 11 98,781,558 (GRCm39) missense probably benign 0.04
R6037:Wipf2 UTSW 11 98,787,005 (GRCm39) missense probably benign 0.11
R6037:Wipf2 UTSW 11 98,787,005 (GRCm39) missense probably benign 0.11
R8965:Wipf2 UTSW 11 98,783,497 (GRCm39) missense probably benign 0.01
R8987:Wipf2 UTSW 11 98,783,092 (GRCm39) missense probably damaging 1.00
R9381:Wipf2 UTSW 11 98,787,068 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATCAGAACAGGACCCAGTG -3'
(R):5'- CTAGGCTGTCCACAATGAGTTC -3'

Sequencing Primer
(F):5'- ACCCAGTGGCCAGTCTCTG -3'
(R):5'- TTACCAACATATAAAAAGGCACCC -3'
Posted On 2015-01-23