Incidental Mutation 'R2879:Ccnj'
ID 260263
Institutional Source Beutler Lab
Gene Symbol Ccnj
Ensembl Gene ENSMUSG00000025010
Gene Name cyclin J
Synonyms D430039C20Rik
MMRRC Submission 040467-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R2879 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 40819723-40837016 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 40833158 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 112 (L112Q)
Ref Sequence ENSEMBL: ENSMUSP00000113712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025983] [ENSMUST00000119316] [ENSMUST00000120057]
AlphaFold Q3TZI6
Predicted Effect probably damaging
Transcript: ENSMUST00000025983
AA Change: L112Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025983
Gene: ENSMUSG00000025010
AA Change: L112Q

DomainStartEndE-ValueType
CYCLIN 45 136 1.59e-13 SMART
Cyclin_C 145 282 7.02e-21 SMART
CYCLIN 153 248 2.1e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119316
AA Change: L112Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112643
Gene: ENSMUSG00000025010
AA Change: L112Q

DomainStartEndE-ValueType
CYCLIN 45 136 1.59e-13 SMART
Cyclin_C 145 282 7.02e-21 SMART
CYCLIN 153 248 2.1e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000120057
AA Change: L112Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113712
Gene: ENSMUSG00000025010
AA Change: L112Q

DomainStartEndE-ValueType
CYCLIN 45 136 1.59e-13 SMART
Cyclin_C 145 270 6.99e-7 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 G C 17: 24,508,481 (GRCm39) T1018R probably damaging Het
Acte1 T A 7: 143,447,800 (GRCm39) Y214* probably null Het
Akap9 A G 5: 4,026,353 (GRCm39) probably benign Het
Ankrd29 G A 18: 12,387,757 (GRCm39) A275V possibly damaging Het
Ano6 T A 15: 95,841,308 (GRCm39) C468* probably null Het
Arhgef10l G T 4: 140,242,598 (GRCm39) H890Q probably benign Het
Chaf1a T C 17: 56,351,114 (GRCm39) probably null Het
Chchd4 A G 6: 91,442,200 (GRCm39) S73P probably damaging Het
Chd3 T C 11: 69,254,924 (GRCm39) K139E possibly damaging Het
Cyp2b13 T G 7: 25,785,456 (GRCm39) probably null Het
Dagla T C 19: 10,248,448 (GRCm39) I71V possibly damaging Het
Epor A T 9: 21,870,936 (GRCm39) W315R probably damaging Het
Etv1 T A 12: 38,833,809 (GRCm39) probably null Het
Fbn2 A T 18: 58,202,314 (GRCm39) C1280S probably damaging Het
Fbxo2 G C 4: 148,250,468 (GRCm39) R269P probably damaging Het
Fer1l4 A T 2: 155,894,120 (GRCm39) L61Q probably damaging Het
Ggnbp2 C T 11: 84,723,797 (GRCm39) probably null Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Ibsp G A 5: 104,458,260 (GRCm39) E266K possibly damaging Het
Lamb3 T A 1: 193,013,092 (GRCm39) M439K possibly damaging Het
Lnx1 C T 5: 74,780,784 (GRCm39) V246M probably benign Het
Lrrc32 A G 7: 98,148,984 (GRCm39) Q588R probably benign Het
Magi2 A AG 5: 20,807,459 (GRCm39) probably null Het
Med13 C T 11: 86,189,988 (GRCm39) A974T possibly damaging Het
Mogat2 A T 7: 98,871,573 (GRCm39) I246N possibly damaging Het
Myl2 T C 5: 122,242,748 (GRCm39) probably null Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or1p1c T A 11: 74,161,049 (GRCm39) V278D probably damaging Het
Osbpl8 T A 10: 111,105,297 (GRCm39) S251T probably benign Het
Pik3r2 A G 8: 71,225,029 (GRCm39) Y145H probably benign Het
Plg A G 17: 12,622,987 (GRCm39) E509G possibly damaging Het
Pnkp T A 7: 44,508,102 (GRCm39) S142T probably damaging Het
Ros1 C T 10: 52,048,936 (GRCm39) probably null Het
Sbno1 A G 5: 124,526,635 (GRCm39) M960T probably damaging Het
Smad1 T C 8: 80,080,084 (GRCm39) probably null Het
Ssc5d G A 7: 4,939,906 (GRCm39) probably null Het
Tfcp2 C T 15: 100,449,201 (GRCm39) probably null Het
Tmem121 A G 12: 113,152,028 (GRCm39) Y82C probably damaging Het
Tmem131 T C 1: 36,880,788 (GRCm39) I161V possibly damaging Het
Tpp2 T A 1: 44,010,783 (GRCm39) F523L probably damaging Het
Ttn C T 2: 76,601,849 (GRCm39) silent Het
Ttpal A G 2: 163,457,503 (GRCm39) probably null Het
Vdr T A 15: 97,757,008 (GRCm39) Y288F probably benign Het
Wipf2 C T 11: 98,783,480 (GRCm39) A302V probably benign Het
Zfp346 T G 13: 55,253,163 (GRCm39) C3G possibly damaging Het
Other mutations in Ccnj
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01903:Ccnj APN 19 40,834,454 (GRCm39) missense probably damaging 1.00
IGL02584:Ccnj APN 19 40,833,185 (GRCm39) missense probably benign 0.04
R0220:Ccnj UTSW 19 40,833,254 (GRCm39) missense probably damaging 0.99
R0452:Ccnj UTSW 19 40,833,508 (GRCm39) splice site probably null
R0693:Ccnj UTSW 19 40,825,551 (GRCm39) missense probably damaging 1.00
R1600:Ccnj UTSW 19 40,833,101 (GRCm39) splice site probably benign
R2237:Ccnj UTSW 19 40,834,219 (GRCm39) missense probably benign 0.00
R2258:Ccnj UTSW 19 40,834,277 (GRCm39) missense probably benign 0.00
R6162:Ccnj UTSW 19 40,833,606 (GRCm39) missense probably damaging 1.00
R6384:Ccnj UTSW 19 40,834,451 (GRCm39) missense probably benign 0.09
R6528:Ccnj UTSW 19 40,820,529 (GRCm39) splice site probably null
R6830:Ccnj UTSW 19 40,833,636 (GRCm39) missense probably damaging 0.99
R7338:Ccnj UTSW 19 40,825,477 (GRCm39) missense probably damaging 1.00
R7346:Ccnj UTSW 19 40,833,394 (GRCm39) missense probably benign 0.28
R8472:Ccnj UTSW 19 40,833,608 (GRCm39) missense probably damaging 0.97
R8977:Ccnj UTSW 19 40,833,383 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGATGCAAGGACATCTGTG -3'
(R):5'- TGCAGAGACACTTCCAGGAAG -3'

Sequencing Primer
(F):5'- TGTGAGATGGAGGAGAGTGCTC -3'
(R):5'- CCAGGAAGTAATCTGCATATTTGGCC -3'
Posted On 2015-01-23