Mutagenetix > Incidental Mutation

Incidental Mutation 'R2880:Gm4076'

260292

Institutional Source

Beutler Lab

Gene Symbol

Gm4076

Ensembl Gene

ENSMUSG00000096449

Gene Name

predicted gene 4076

Synonyms

MMRRC Submission

040468-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.276) question?

Stock #

R2880 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85274669-85275633 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

G to A at 85275357 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179230

SMART Domains

Protein: ENSMUSP00000137467
Gene: ENSMUSG00000096449

Domain	Start	End	E-Value	Type
Pfam:Proton_antipo_M	1	171	2.9e-47	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ano4	C	T	10: 88,948,661 (GRCm39)	E150K	probably damaging	Het
Blnk	T	C	19: 40,950,899 (GRCm39)	Y84C	probably damaging	Het
Brinp3	G	A	1: 146,777,740 (GRCm39)	R729H	probably damaging	Het
Bsn	C	T	9: 107,990,266 (GRCm39)	A1829T	possibly damaging	Het
Cd300c	A	T	11: 114,850,616 (GRCm39)	N62K	probably benign	Het
Chd3	T	C	11: 69,242,946 (GRCm39)	D1425G	probably damaging	Het
Ewsr1	C	A	11: 5,028,523 (GRCm39)		probably benign	Het
Gm9637	A	G	14: 19,401,978 (GRCm38)		noncoding transcript	Het
Greb1l	A	T	18: 10,547,288 (GRCm39)	N1502I	possibly damaging	Het
H13	A	G	2: 152,537,481 (GRCm39)	M309V	probably damaging	Het
Lmf2	A	G	15: 89,235,856 (GRCm39)	S683P	possibly damaging	Het
Lrit1	T	A	14: 36,779,394 (GRCm39)	L109Q	probably damaging	Het
Maml2	A	T	9: 13,531,893 (GRCm39)		probably null	Het
Map3k14	C	A	11: 103,111,858 (GRCm39)	R941L	probably damaging	Het
Megf6	A	G	4: 154,337,006 (GRCm39)	K262E	probably damaging	Het
Mtnr1b	T	G	9: 15,774,102 (GRCm39)	Y319S	probably damaging	Het
Myh8	A	G	11: 67,188,090 (GRCm39)	K954R	probably damaging	Het
Myof	T	C	19: 37,911,473 (GRCm39)	D1486G	probably benign	Het
Nbea	A	G	3: 55,554,779 (GRCm39)	V2623A	probably benign	Het
Pak1	T	A	7: 97,554,018 (GRCm39)	Y463N	probably damaging	Het
Pex5l	T	A	3: 33,047,152 (GRCm39)		probably null	Het
Rasa4	T	C	5: 136,120,625 (GRCm39)	V87A	probably damaging	Het
Rnf112	G	A	11: 61,341,293 (GRCm39)	H431Y	possibly damaging	Het
Slc25a30	A	G	14: 76,007,651 (GRCm39)	V118A	probably benign	Het
Slc4a7	T	A	14: 14,773,277 (GRCm38)	I872K	probably damaging	Het
Slc5a11	GGTGC	G	7: 122,838,595 (GRCm39)		probably null	Het
Sycp1	T	C	3: 102,726,214 (GRCm39)	E970G	probably damaging	Het
Tex15	T	A	8: 34,064,935 (GRCm39)	L1455*	probably null	Het
Tgfb2	T	A	1: 186,436,752 (GRCm39)	T74S	probably damaging	Het
Vmn2r65	A	T	7: 84,613,094 (GRCm39)	C42S	probably damaging	Het
Zbtb12	T	A	17: 35,114,455 (GRCm39)	I80N	probably damaging	Het

Other mutations in Gm4076

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL03102:Gm4076	APN	13	85,275,438 (GRCm39)	exon	noncoding transcript
R0499:Gm4076	UTSW	13	85,275,345 (GRCm39)	exon	noncoding transcript
R0879:Gm4076	UTSW	13	85,275,326 (GRCm39)	exon	noncoding transcript
R1027:Gm4076	UTSW	13	85,275,508 (GRCm39)	exon	noncoding transcript
R1117:Gm4076	UTSW	13	85,275,437 (GRCm39)	exon	noncoding transcript
R1892:Gm4076	UTSW	13	85,275,447 (GRCm39)	exon	noncoding transcript
R3551:Gm4076	UTSW	13	85,275,269 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- GAATGGCATTCCTGTGAGGG -3'
(R):5'- AGTAGTTGCAGGAATCTTTCTACTG -3'

Sequencing Primer
(F):5'- GCGAGGCTTCCGATTACTAG -3'
(R):5'- GCAGGAATCTTTCTACTGGTCCG -3'

Posted On

2015-01-23