Incidental Mutation 'R2874:Ralgds'
ID 260446
Institutional Source Beutler Lab
Gene Symbol Ralgds
Ensembl Gene ENSMUSG00000026821
Gene Name ral guanine nucleotide dissociation stimulator
Synonyms RalGDS, Rgds, Gnds
MMRRC Submission 040462-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R2874 (G1)
Quality Score 217
Status Validated
Chromosome 2
Chromosomal Location 28403137-28443093 bp(+) (GRCm39)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) A to G at 28438781 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109526 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028170] [ENSMUST00000100241] [ENSMUST00000113893] [ENSMUST00000140704]
AlphaFold Q03385
Predicted Effect probably null
Transcript: ENSMUST00000028170
SMART Domains Protein: ENSMUSP00000028170
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 56 194 4.02e-37 SMART
low complexity region 239 285 N/A INTRINSIC
RasGEF 320 587 5.28e-118 SMART
low complexity region 613 626 N/A INTRINSIC
low complexity region 646 655 N/A INTRINSIC
low complexity region 683 712 N/A INTRINSIC
low complexity region 716 726 N/A INTRINSIC
RA 736 823 6.51e-22 SMART
Predicted Effect probably null
Transcript: ENSMUST00000100241
SMART Domains Protein: ENSMUSP00000097812
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 111 249 4.02e-37 SMART
low complexity region 294 340 N/A INTRINSIC
RasGEF 375 642 5.28e-118 SMART
low complexity region 668 681 N/A INTRINSIC
low complexity region 701 710 N/A INTRINSIC
low complexity region 738 767 N/A INTRINSIC
low complexity region 771 781 N/A INTRINSIC
RA 791 878 6.51e-22 SMART
Predicted Effect probably null
Transcript: ENSMUST00000113893
SMART Domains Protein: ENSMUSP00000109526
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 111 237 1.25e-42 SMART
low complexity region 282 328 N/A INTRINSIC
RasGEF 363 630 5.28e-118 SMART
low complexity region 656 669 N/A INTRINSIC
low complexity region 689 698 N/A INTRINSIC
low complexity region 726 755 N/A INTRINSIC
low complexity region 759 769 N/A INTRINSIC
RA 779 866 6.51e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128680
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130281
Predicted Effect probably benign
Transcript: ENSMUST00000137215
SMART Domains Protein: ENSMUSP00000116215
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
RasGEFN 1 107 5.55e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137513
Predicted Effect probably benign
Transcript: ENSMUST00000140704
SMART Domains Protein: ENSMUSP00000118966
Gene: ENSMUSG00000026821

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
RA 36 123 6.51e-22 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
PHENOTYPE: Homozygous mutant mice exhibit reduced tumor incidence, size and progression to malignancy in multistage skin carcinogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(16) : Targeted(5) Gene trapped(11)

Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930029G22Rik T A 17: 69,725,106 (GRCm39) noncoding transcript Het
Ankrd42 T C 7: 92,254,566 (GRCm39) K348E possibly damaging Het
Arhgef10 T C 8: 15,025,093 (GRCm39) probably null Het
Arhgef10 A G 8: 15,025,666 (GRCm39) I459V probably benign Het
Cd6 A G 19: 10,771,990 (GRCm39) I307T possibly damaging Het
Cebpz A T 17: 79,239,532 (GRCm39) probably benign Het
Clcn4 A G 7: 7,293,520 (GRCm39) I412T probably benign Het
Clstn3 T A 6: 124,415,294 (GRCm39) D690V probably damaging Het
Col12a1 A T 9: 79,606,831 (GRCm39) F531I probably damaging Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Dhx57 A T 17: 80,558,805 (GRCm39) D1051E probably benign Het
Ext2 A G 2: 93,570,031 (GRCm39) V460A possibly damaging Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Het
Fscb T C 12: 64,520,210 (GRCm39) K419E probably benign Het
Ftdc1 A T 16: 58,434,342 (GRCm39) I125K probably benign Het
Ggct G T 6: 54,969,759 (GRCm39) A21D probably damaging Het
Gm10717 A G 9: 3,025,532 (GRCm39) Y39C probably benign Het
Grid2ip C A 5: 143,343,684 (GRCm39) Q127K probably benign Het
Ighv2-2 G A 12: 113,552,118 (GRCm39) T40I possibly damaging Het
Itpr2 T C 6: 146,327,996 (GRCm39) K79R possibly damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Het
Kpna7 T C 5: 144,930,745 (GRCm39) T367A probably benign Het
Lactbl1 G A 4: 136,354,097 (GRCm39) C37Y probably damaging Het
Lrp1b A G 2: 40,741,705 (GRCm39) L3188P probably damaging Het
Matcap1 A G 8: 106,008,664 (GRCm39) M451T possibly damaging Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Noc4l A G 5: 110,796,969 (GRCm39) V465A probably benign Het
Notch1 A G 2: 26,350,247 (GRCm39) C2298R possibly damaging Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Plxna3 T A X: 73,383,002 (GRCm39) probably benign Het
Prdx4 A G X: 154,123,460 (GRCm39) V15A probably benign Het
Prps1 C T X: 139,372,743 (GRCm39) probably benign Het
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Qng1 T A 13: 58,530,384 (GRCm39) I209F probably damaging Het
Rasl12 A G 9: 65,315,605 (GRCm39) N83S probably benign Het
Rnf6 T C 5: 146,147,215 (GRCm39) Y601C probably benign Het
Rreb1 T C 13: 38,100,484 (GRCm39) I205T probably benign Het
Sgk2 A G 2: 162,836,449 (GRCm39) probably benign Het
Spsb4 G T 9: 96,878,071 (GRCm39) T84K probably damaging Het
St7 C T 6: 17,819,276 (GRCm39) P60L probably damaging Het
Stx3 A T 19: 11,766,938 (GRCm39) V91D probably damaging Het
Tbc1d8 A G 1: 39,444,398 (GRCm39) F187S probably damaging Het
Tep1 A G 14: 51,088,107 (GRCm39) I85T possibly damaging Het
Trpa1 A G 1: 14,957,844 (GRCm39) C705R probably damaging Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Other mutations in Ralgds
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00426:Ralgds APN 2 28,442,230 (GRCm39) missense probably damaging 1.00
IGL01774:Ralgds APN 2 28,440,554 (GRCm39) nonsense probably null
IGL02747:Ralgds APN 2 28,438,122 (GRCm39) unclassified probably benign
IGL03135:Ralgds APN 2 28,439,100 (GRCm39) missense probably damaging 0.99
PIT4458001:Ralgds UTSW 2 28,432,486 (GRCm39) missense probably damaging 1.00
PIT4531001:Ralgds UTSW 2 28,435,226 (GRCm39) nonsense probably null
R0049:Ralgds UTSW 2 28,432,391 (GRCm39) synonymous silent
R0052:Ralgds UTSW 2 28,434,400 (GRCm39) critical splice donor site probably null
R0052:Ralgds UTSW 2 28,434,400 (GRCm39) critical splice donor site probably null
R0285:Ralgds UTSW 2 28,440,581 (GRCm39) splice site probably null
R0665:Ralgds UTSW 2 28,435,218 (GRCm39) missense probably damaging 0.98
R0718:Ralgds UTSW 2 28,439,128 (GRCm39) missense probably benign 0.37
R1755:Ralgds UTSW 2 28,440,558 (GRCm39) missense probably damaging 0.99
R1966:Ralgds UTSW 2 28,435,887 (GRCm39) missense probably damaging 0.96
R2873:Ralgds UTSW 2 28,438,781 (GRCm39) splice site probably null
R4082:Ralgds UTSW 2 28,442,283 (GRCm39) utr 3 prime probably benign
R4342:Ralgds UTSW 2 28,442,107 (GRCm39) missense probably damaging 1.00
R4344:Ralgds UTSW 2 28,442,107 (GRCm39) missense probably damaging 1.00
R4647:Ralgds UTSW 2 28,435,532 (GRCm39) critical splice donor site probably null
R4738:Ralgds UTSW 2 28,435,428 (GRCm39) missense probably damaging 1.00
R4762:Ralgds UTSW 2 28,442,164 (GRCm39) missense probably damaging 0.97
R5027:Ralgds UTSW 2 28,442,102 (GRCm39) critical splice acceptor site probably null
R5320:Ralgds UTSW 2 28,435,224 (GRCm39) missense probably damaging 1.00
R5738:Ralgds UTSW 2 28,432,538 (GRCm39) intron probably benign
R5969:Ralgds UTSW 2 28,432,426 (GRCm39) missense probably damaging 1.00
R6014:Ralgds UTSW 2 28,433,673 (GRCm39) missense probably damaging 0.97
R6136:Ralgds UTSW 2 28,440,577 (GRCm39) critical splice donor site probably null
R6137:Ralgds UTSW 2 28,437,600 (GRCm39) missense probably damaging 0.99
R6583:Ralgds UTSW 2 28,423,656 (GRCm39) missense probably damaging 0.99
R6618:Ralgds UTSW 2 28,440,523 (GRCm39) missense probably benign 0.09
R6801:Ralgds UTSW 2 28,438,448 (GRCm39) missense probably damaging 1.00
R7046:Ralgds UTSW 2 28,430,741 (GRCm39) missense probably damaging 1.00
R7095:Ralgds UTSW 2 28,439,320 (GRCm39) missense possibly damaging 0.83
R7276:Ralgds UTSW 2 28,435,884 (GRCm39) missense probably damaging 1.00
R7399:Ralgds UTSW 2 28,433,667 (GRCm39) missense possibly damaging 0.95
R7446:Ralgds UTSW 2 28,435,901 (GRCm39) missense probably damaging 0.99
R7560:Ralgds UTSW 2 28,437,607 (GRCm39) missense probably damaging 1.00
R8384:Ralgds UTSW 2 28,437,182 (GRCm39) missense probably damaging 1.00
R9422:Ralgds UTSW 2 28,435,184 (GRCm39) missense probably benign
X0028:Ralgds UTSW 2 28,438,711 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATGATGTCATCACTGTTGCCTG -3'
(R):5'- CAGGAAACACTTGGCTTACTCTC -3'

Sequencing Primer
(F):5'- TGGTGACAGCTGCGTATCCAG -3'
(R):5'- AAACACTTGGCTTACTCTCAGGGTC -3'
Posted On 2015-01-23