Mutagenetix > Incidental Mutation

Incidental Mutation 'R2875:Dock2'

260515

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, Hch, MBC

MMRRC Submission

040463-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2875 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

34176815-34674719 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 34609712 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 243 (S243P)

Ref Sequence

ENSEMBL: ENSMUSP00000116893 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000143540]

AlphaFold

Q8C3J5

Predicted Effect

probably damaging
Transcript: ENSMUST00000093193
AA Change: S243P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: S243P

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000101365
AA Change: S243P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: S243P

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000143540
AA Change: S243P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000116893
Gene: ENSMUSG00000020143
AA Change: S243P

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK-C2	418	617	1.8e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154178

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.3%

Validation Efficiency

100% (1/1)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam34l	T	A	8: 44,080,177 (GRCm39)	K16*	probably null	Het
Adgb	T	G	10: 10,298,463 (GRCm39)	T422P	probably damaging	Het
Adrm1	A	G	2: 179,817,411 (GRCm39)	T293A	probably damaging	Het
Baz1a	A	T	12: 54,969,904 (GRCm39)	D585E	probably damaging	Het
Ccdc152	T	C	15: 3,327,663 (GRCm39)	N38S	probably damaging	Het
Cenpf	A	G	1: 189,390,841 (GRCm39)	M997T	probably benign	Het
Dnah12	A	G	14: 26,414,625 (GRCm39)	I9V	probably benign	Het
Dnah12	A	G	14: 26,598,907 (GRCm39)	N995S	probably benign	Het
Dnah9	C	A	11: 66,059,287 (GRCm39)	G3C	possibly damaging	Het
Eif2ak3	T	C	6: 70,860,623 (GRCm39)	S400P	probably damaging	Het
Eno1b	A	G	18: 48,180,851 (GRCm39)	K343R	possibly damaging	Het
Grk6	A	G	13: 55,600,117 (GRCm39)	H271R	probably damaging	Het
H2-Ab1	A	C	17: 34,482,286 (GRCm39)	M1L	probably benign	Het
Irf8	C	A	8: 121,481,202 (GRCm39)	P262Q	probably damaging	Het
Kcnc3	G	T	7: 44,240,961 (GRCm39)	G218*	probably null	Het
Krt9	C	A	11: 100,080,031 (GRCm39)	G454*	probably null	Het
Mgrn1	C	T	16: 4,725,280 (GRCm39)	T47I	possibly damaging	Het
Ndst1	A	T	18: 60,823,119 (GRCm39)	F816I	probably damaging	Het
Or11g26	T	A	14: 50,753,269 (GRCm39)	W203R	probably benign	Het
Or5h25	A	T	16: 58,930,165 (GRCm39)	D269E	probably benign	Het
Phf12	C	A	11: 77,900,573 (GRCm39)	T223N	probably damaging	Het
Rad1	T	C	15: 10,490,417 (GRCm39)	V128A	probably benign	Het
Rad54l	C	T	4: 115,959,050 (GRCm39)	R382Q	probably benign	Het
Rhbdd1	A	G	1: 82,346,090 (GRCm39)	D215G	probably benign	Het
Sdc4	T	C	2: 164,273,211 (GRCm39)	D33G	possibly damaging	Het
Smarca4	A	T	9: 21,553,876 (GRCm39)	K387N	possibly damaging	Het
St3gal5	A	G	6: 72,124,114 (GRCm39)	M214V	possibly damaging	Het
Stk25	T	C	1: 93,556,973 (GRCm39)	D15G	possibly damaging	Het
Timm21	T	C	18: 84,969,217 (GRCm39)	D69G	probably benign	Het
Ttll4	A	G	1: 74,725,597 (GRCm39)		probably null	Het
Ttn	T	A	2: 76,589,438 (GRCm39)	N21272I	probably damaging	Het
Uchl3	A	G	14: 101,905,996 (GRCm39)	H153R	probably benign	Het
Zbed6	C	T	1: 133,584,598 (GRCm39)	C913Y	probably damaging	Het
Zcwpw1	T	C	5: 137,808,304 (GRCm39)	S251P	probably damaging	Het
Zeb1	GGA	GGAAGA	18: 5,772,859 (GRCm39)		probably benign	Het
Zscan29	T	C	2: 120,994,581 (GRCm39)	Y468C	probably damaging	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,595,488 (GRCm39)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,179,603 (GRCm39)	splice site	probably benign
IGL01061:Dock2	APN	11	34,596,653 (GRCm39)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,589,617 (GRCm39)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,260,390 (GRCm39)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,596,608 (GRCm39)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,189,528 (GRCm39)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,647,100 (GRCm39)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,212,433 (GRCm39)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,212,391 (GRCm39)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,596,668 (GRCm39)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,582,744 (GRCm39)	nonsense	probably null
IGL01835:Dock2	APN	11	34,260,435 (GRCm39)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,599,692 (GRCm39)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,623,183 (GRCm39)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,218,053 (GRCm39)	missense	probably benign
IGL02081:Dock2	APN	11	34,204,355 (GRCm39)	missense	probably benign
IGL02105:Dock2	APN	11	34,605,352 (GRCm39)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,180,670 (GRCm39)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,217,949 (GRCm39)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,622,337 (GRCm39)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,589,567 (GRCm39)	splice site	probably benign
IGL02409:Dock2	APN	11	34,451,204 (GRCm39)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,199,801 (GRCm39)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,451,168 (GRCm39)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,218,048 (GRCm39)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,260,448 (GRCm39)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,583,086 (GRCm39)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,578,360 (GRCm39)	missense	probably damaging	0.99
Arches	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
denali	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
dew	UTSW	11	34,198,636 (GRCm39)	nonsense	probably null
Dinghy	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
Dry	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
frazz	UTSW	11	34,198,572 (GRCm39)	critical splice donor site	probably benign
frizz	UTSW	11	34,208,184 (GRCm39)	splice site	probably benign
gildenstern	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
godsgrace	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
Harborside	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
Landing	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
latest	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
Launch	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
liaoning	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
lucre	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
midas	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
muelle	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
narrowest	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
pier	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
Plank	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
riches	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
skiff	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
Slip	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
toothskin	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
Touch	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
wassup	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
Wharf	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,182,853 (GRCm39)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,611,835 (GRCm39)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,262,453 (GRCm39)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,579,392 (GRCm39)	intron	probably benign
R0149:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,218,052 (GRCm39)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,579,380 (GRCm39)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,595,545 (GRCm39)	splice site	probably benign
R0543:Dock2	UTSW	11	34,244,325 (GRCm39)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,198,621 (GRCm39)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,586,063 (GRCm39)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,414,970 (GRCm39)	splice site	probably benign
R0801:Dock2	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,206,535 (GRCm39)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,586,068 (GRCm39)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,223,309 (GRCm39)	splice site	probably benign
R1445:Dock2	UTSW	11	34,189,705 (GRCm39)	missense	probably benign
R1494:Dock2	UTSW	11	34,232,761 (GRCm39)	nonsense	probably null
R1589:Dock2	UTSW	11	34,597,288 (GRCm39)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,595,474 (GRCm39)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,212,480 (GRCm39)	splice site	probably null
R1749:Dock2	UTSW	11	34,182,767 (GRCm39)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,414,934 (GRCm39)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,618,297 (GRCm39)	splice site	probably benign
R2045:Dock2	UTSW	11	34,244,106 (GRCm39)	splice site	probably null
R2098:Dock2	UTSW	11	34,609,832 (GRCm39)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,216,279 (GRCm39)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,618,242 (GRCm39)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34,262,485 (GRCm39)	missense	probably benign	0.04
R2885:Dock2	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,182,910 (GRCm39)	splice site	probably benign
R3081:Dock2	UTSW	11	34,181,610 (GRCm39)	missense	probably benign
R3418:Dock2	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,611,787 (GRCm39)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,599,722 (GRCm39)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,244,118 (GRCm39)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,586,298 (GRCm39)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,223,767 (GRCm39)	splice site	probably null
R4884:Dock2	UTSW	11	34,216,248 (GRCm39)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,586,078 (GRCm39)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,178,643 (GRCm39)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,618,233 (GRCm39)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,204,391 (GRCm39)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,199,836 (GRCm39)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
R5860:Dock2	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,599,614 (GRCm39)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,244,123 (GRCm39)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,197,789 (GRCm39)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,179,476 (GRCm39)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,453,396 (GRCm39)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,598,152 (GRCm39)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,182,874 (GRCm39)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,312,822 (GRCm39)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,670 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,669 (GRCm39)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,177,684 (GRCm39)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,260,363 (GRCm39)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,189,675 (GRCm39)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,181,677 (GRCm39)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,605,340 (GRCm39)	nonsense	probably null
R7250:Dock2	UTSW	11	34,586,120 (GRCm39)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,586,032 (GRCm39)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,180,672 (GRCm39)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,609,816 (GRCm39)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,586,105 (GRCm39)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,262,542 (GRCm39)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,611,778 (GRCm39)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,605,282 (GRCm39)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,223,698 (GRCm39)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,598,154 (GRCm39)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,596,677 (GRCm39)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,260,362 (GRCm39)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,609,795 (GRCm39)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,180,825 (GRCm39)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,181,622 (GRCm39)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,212,457 (GRCm39)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
R8743:Dock2	UTSW	11	34,223,252 (GRCm39)	nonsense	probably null
R8757:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,451,215 (GRCm39)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
R8885:Dock2	UTSW	11	34,260,396 (GRCm39)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,599,646 (GRCm39)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,589,670 (GRCm39)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,260,398 (GRCm39)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,622,366 (GRCm39)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,244,139 (GRCm39)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,589,582 (GRCm39)	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34,599,638 (GRCm39)	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34,178,607 (GRCm39)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,218,054 (GRCm39)	missense	probably benign
R9697:Dock2	UTSW	11	34,204,417 (GRCm39)	missense	probably benign
R9753:Dock2	UTSW	11	34,223,673 (GRCm39)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,208,128 (GRCm39)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,216,271 (GRCm39)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,182,833 (GRCm39)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,206,564 (GRCm39)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,260,357 (GRCm39)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,583,209 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,388,300 (GRCm39)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,586,039 (GRCm39)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,609,751 (GRCm39)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,262,553 (GRCm39)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- TCATCACCATAAATCCGCTGAG -3'
(R):5'- AGTGGCATTGGGATAGCATG -3'

Sequencing Primer
(F):5'- GCCTCCAAAAGGGTTCTCC -3'
(R):5'- GCATTGGGATAGCATGTTATATCTTC -3'

Posted On

2015-01-23