Incidental Mutation 'R2877:Mslnl'
| ID |
260640 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mslnl
|
| Ensembl Gene |
ENSMUSG00000041062 |
| Gene Name |
mesothelin-like |
| Synonyms |
|
| MMRRC Submission |
040465-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2877 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
25955016-25967304 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 25961908 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 128
(V128M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
|
| AlphaFold |
Q8C160 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047098
AA Change: V128M
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: V128M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
|
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000102319
|
| Meta Mutation Damage Score |
0.2148 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
96% (66/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 58 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
C |
5: 109,886,811 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
C |
T |
11: 9,241,889 (GRCm39) |
L1251F |
possibly damaging |
Het |
| Accsl |
A |
T |
2: 93,689,755 (GRCm39) |
M384K |
probably damaging |
Het |
| Adss1 |
A |
C |
12: 112,600,623 (GRCm39) |
K197N |
probably damaging |
Het |
| Alg11 |
A |
G |
8: 22,555,374 (GRCm39) |
N170D |
possibly damaging |
Het |
| Ambn |
T |
C |
5: 88,608,559 (GRCm39) |
|
probably benign |
Het |
| Anapc7 |
T |
C |
5: 122,566,219 (GRCm39) |
Y43H |
probably benign |
Het |
| Anxa10 |
T |
A |
8: 62,513,373 (GRCm39) |
I255F |
probably damaging |
Het |
| Atg2b |
A |
T |
12: 105,630,268 (GRCm39) |
Y374* |
probably null |
Het |
| Axl |
T |
A |
7: 25,465,949 (GRCm39) |
M563L |
probably damaging |
Het |
| Carmil2 |
A |
G |
8: 106,422,055 (GRCm39) |
E1108G |
probably damaging |
Het |
| Casp1 |
T |
C |
9: 5,303,110 (GRCm39) |
M188T |
probably damaging |
Het |
| Chd3 |
A |
T |
11: 69,251,998 (GRCm39) |
C87* |
probably null |
Het |
| Col6a3 |
G |
A |
1: 90,703,321 (GRCm39) |
T2475I |
unknown |
Het |
| Creb3l4 |
A |
T |
3: 90,149,615 (GRCm39) |
S83R |
probably damaging |
Het |
| Cyp2a4 |
G |
A |
7: 26,011,612 (GRCm39) |
E278K |
possibly damaging |
Het |
| Dync1li2 |
A |
C |
8: 105,156,047 (GRCm39) |
Y265D |
probably damaging |
Het |
| Eif3f |
G |
A |
7: 108,534,019 (GRCm39) |
|
probably null |
Het |
| Eipr1 |
C |
T |
12: 28,810,091 (GRCm39) |
T22I |
possibly damaging |
Het |
| Fbxo48 |
A |
G |
11: 16,903,382 (GRCm39) |
K3E |
possibly damaging |
Het |
| Fbxw13 |
A |
G |
9: 109,010,534 (GRCm39) |
F368S |
probably damaging |
Het |
| Fbxw19 |
A |
T |
9: 109,315,038 (GRCm39) |
W175R |
probably damaging |
Het |
| Fibcd1 |
G |
A |
2: 31,728,678 (GRCm39) |
P60S |
probably benign |
Het |
| Foxa3 |
A |
T |
7: 18,748,805 (GRCm39) |
M107K |
probably benign |
Het |
| Foxj2 |
G |
A |
6: 122,819,791 (GRCm39) |
D560N |
probably damaging |
Het |
| Gfm2 |
A |
G |
13: 97,289,757 (GRCm39) |
R181G |
possibly damaging |
Het |
| Gpr25 |
C |
T |
1: 136,188,553 (GRCm39) |
G20D |
possibly damaging |
Het |
| Grin1 |
A |
G |
2: 25,187,641 (GRCm39) |
V594A |
probably damaging |
Het |
| Itpripl1 |
A |
G |
2: 126,983,534 (GRCm39) |
V196A |
probably benign |
Het |
| Kcns1 |
A |
G |
2: 164,006,682 (GRCm39) |
I427T |
probably damaging |
Het |
| Kiz |
T |
C |
2: 146,731,476 (GRCm39) |
V322A |
possibly damaging |
Het |
| Muc19 |
T |
A |
15: 91,777,200 (GRCm39) |
|
noncoding transcript |
Het |
| Naa16 |
A |
G |
14: 79,580,738 (GRCm39) |
M592T |
probably benign |
Het |
| Naa80 |
A |
T |
9: 107,460,367 (GRCm39) |
E87D |
possibly damaging |
Het |
| Ncapd3 |
T |
A |
9: 26,955,783 (GRCm39) |
|
probably null |
Het |
| Nebl |
C |
A |
2: 17,439,740 (GRCm39) |
D178Y |
probably damaging |
Het |
| Nedd1 |
T |
A |
10: 92,549,988 (GRCm39) |
N99I |
possibly damaging |
Het |
| Nuak1 |
T |
C |
10: 84,211,209 (GRCm39) |
D293G |
possibly damaging |
Het |
| Or5b123 |
A |
T |
19: 13,596,996 (GRCm39) |
I157F |
probably damaging |
Het |
| Or5m9b |
T |
C |
2: 85,905,675 (GRCm39) |
M197T |
possibly damaging |
Het |
| Palb2 |
A |
G |
7: 121,713,652 (GRCm39) |
V877A |
probably damaging |
Het |
| Rassf6 |
C |
T |
5: 90,754,664 (GRCm39) |
V205I |
probably damaging |
Het |
| Rbak |
A |
G |
5: 143,159,860 (GRCm39) |
Y398H |
probably damaging |
Het |
| Rcbtb1 |
A |
G |
14: 59,448,041 (GRCm39) |
|
probably benign |
Het |
| Robo4 |
CGG |
CG |
9: 37,322,786 (GRCm39) |
|
probably null |
Het |
| Smpdl3a |
C |
A |
10: 57,685,181 (GRCm39) |
T317K |
probably damaging |
Het |
| Speer4e1 |
C |
T |
5: 14,987,130 (GRCm39) |
V92M |
probably damaging |
Het |
| Syne2 |
A |
G |
12: 76,047,605 (GRCm39) |
I4009V |
probably benign |
Het |
| Tarbp1 |
G |
A |
8: 127,154,571 (GRCm39) |
L1474F |
probably damaging |
Het |
| Tchh |
A |
G |
3: 93,351,535 (GRCm39) |
E325G |
unknown |
Het |
| Trpc4 |
T |
C |
3: 54,198,761 (GRCm39) |
S562P |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,567,409 (GRCm39) |
D27828G |
probably damaging |
Het |
| Ulk4 |
T |
C |
9: 121,089,105 (GRCm39) |
D258G |
probably benign |
Het |
| Vmn1r215 |
A |
G |
13: 23,260,731 (GRCm39) |
H257R |
probably benign |
Het |
| Vmn2r56 |
A |
C |
7: 12,444,954 (GRCm39) |
M433R |
probably benign |
Het |
| Vmn2r76 |
C |
A |
7: 85,875,201 (GRCm39) |
C592F |
probably benign |
Het |
| Zcchc8 |
C |
T |
5: 123,838,766 (GRCm39) |
V591I |
probably benign |
Het |
| Znhit6 |
G |
C |
3: 145,282,409 (GRCm39) |
G96A |
probably benign |
Het |
|
| Other mutations in Mslnl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01621:Mslnl
|
APN |
17 |
25,962,641 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01629:Mslnl
|
APN |
17 |
25,963,749 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02084:Mslnl
|
APN |
17 |
25,965,125 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02408:Mslnl
|
APN |
17 |
25,966,972 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02726:Mslnl
|
APN |
17 |
25,963,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03387:Mslnl
|
APN |
17 |
25,963,051 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0561:Mslnl
|
UTSW |
17 |
25,962,177 (GRCm39) |
nonsense |
probably null |
|
|
R0881:Mslnl
|
UTSW |
17 |
25,961,939 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1295:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1296:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1582:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1629:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1630:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1631:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1632:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1794:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1850:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1866:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1876:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1914:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2166:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2241:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2243:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2247:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2282:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2284:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2852:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2878:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2919:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2920:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3026:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3405:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3406:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3411:Mslnl
|
UTSW |
17 |
25,963,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3434:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3546:Mslnl
|
UTSW |
17 |
25,963,943 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3612:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3729:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3730:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3802:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3804:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3894:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3895:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4454:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4455:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4456:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4457:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4561:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4562:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4564:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4600:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4601:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4610:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4704:Mslnl
|
UTSW |
17 |
25,957,952 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5155:Mslnl
|
UTSW |
17 |
25,957,942 (GRCm39) |
nonsense |
probably null |
|
|
R5257:Mslnl
|
UTSW |
17 |
25,965,139 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5456:Mslnl
|
UTSW |
17 |
25,962,133 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5645:Mslnl
|
UTSW |
17 |
25,956,816 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6007:Mslnl
|
UTSW |
17 |
25,965,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6083:Mslnl
|
UTSW |
17 |
25,956,876 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6142:Mslnl
|
UTSW |
17 |
25,963,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6761:Mslnl
|
UTSW |
17 |
25,965,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Mslnl
|
UTSW |
17 |
25,962,186 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7156:Mslnl
|
UTSW |
17 |
25,962,184 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7467:Mslnl
|
UTSW |
17 |
25,955,895 (GRCm39) |
start codon destroyed |
probably benign |
0.33 |
|
R7687:Mslnl
|
UTSW |
17 |
25,962,157 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7807:Mslnl
|
UTSW |
17 |
25,965,751 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8682:Mslnl
|
UTSW |
17 |
25,965,962 (GRCm39) |
missense |
probably benign |
|
|
R8735:Mslnl
|
UTSW |
17 |
25,964,062 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8742:Mslnl
|
UTSW |
17 |
25,964,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9208:Mslnl
|
UTSW |
17 |
25,961,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9264:Mslnl
|
UTSW |
17 |
25,961,506 (GRCm39) |
intron |
probably benign |
|
|
RF007:Mslnl
|
UTSW |
17 |
25,962,202 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCATCAGAAGGGAGGTTTG -3'
(R):5'- ACAGGTCTGAAGCACTGAGC -3'
Sequencing Primer
(F):5'- TTTGAACCCAGGACTGAGGTGAC -3'
(R):5'- GCCCTGCCGAGACAGTAG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation