Incidental Mutation 'R2893:Vmn2r80'
ID 260675
Institutional Source Beutler Lab
Gene Symbol Vmn2r80
Ensembl Gene ENSMUSG00000091888
Gene Name vomeronasal 2, receptor 80
Synonyms EG624765
MMRRC Submission 040481-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R2893 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 78984650-79030767 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78984699 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 17 (F17S)
Ref Sequence ENSEMBL: ENSMUSP00000132299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165834]
AlphaFold E9Q1L0
Predicted Effect possibly damaging
Transcript: ENSMUST00000165834
AA Change: F17S

PolyPhen 2 Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: F17S

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 79 474 1.5e-36 PFAM
Pfam:NCD3G 517 570 7.9e-22 PFAM
Pfam:7tm_3 603 838 6.2e-49 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Abl1 T G 2: 31,687,624 (GRCm39) S521R probably benign Het
Acox3 A G 5: 35,757,192 (GRCm39) I344V probably benign Het
Ank2 T C 3: 127,041,892 (GRCm39) probably null Het
Atoh8 A T 6: 72,211,856 (GRCm39) F98Y probably benign Het
Caskin2 C T 11: 115,692,103 (GRCm39) G894E probably benign Het
Cdh15 G A 8: 123,583,374 (GRCm39) R59H probably benign Het
Cdk5rap2 T C 4: 70,208,110 (GRCm39) K779E probably benign Het
Csmd2 T A 4: 128,432,786 (GRCm39) probably null Het
Cubn T C 2: 13,362,950 (GRCm39) D1687G possibly damaging Het
F11 A G 8: 45,701,675 (GRCm39) S353P probably damaging Het
Faap100 T C 11: 120,265,451 (GRCm39) D475G probably damaging Het
Fhip2a C T 19: 57,372,601 (GRCm39) P617L probably benign Het
Gm13090 T A 4: 151,175,157 (GRCm39) L78* probably null Het
Ikbke G A 1: 131,197,961 (GRCm39) P382S probably damaging Het
Il4i1 A G 7: 44,487,414 (GRCm39) I130V probably damaging Het
Islr2 A T 9: 58,105,149 (GRCm39) S704T probably damaging Het
Itga10 A G 3: 96,562,416 (GRCm39) N733D probably benign Het
Itih2 C T 2: 10,107,008 (GRCm39) G662D possibly damaging Het
Kansl1l T C 1: 66,840,493 (GRCm39) Q269R probably damaging Het
Kcnj3 A T 2: 55,337,027 (GRCm39) I298F probably damaging Het
Kdr A G 5: 76,107,496 (GRCm39) F1016L probably damaging Het
Miga2 A T 2: 30,268,306 (GRCm39) probably null Het
Or51ai2 A T 7: 103,587,389 (GRCm39) R267S probably damaging Het
Per2 C A 1: 91,373,325 (GRCm39) Q154H probably damaging Het
Pik3ap1 G A 19: 41,364,500 (GRCm39) A73V probably benign Het
Plod3 G C 5: 137,017,000 (GRCm39) A50P probably benign Het
Psma5-ps T C 10: 85,149,848 (GRCm39) noncoding transcript Het
Rad18 G A 6: 112,652,734 (GRCm39) Q288* probably null Het
Rapsn A T 2: 90,867,169 (GRCm39) D157V probably damaging Het
Slc2a8 A T 2: 32,864,966 (GRCm39) W394R probably damaging Het
Srcap T C 7: 127,138,237 (GRCm39) S1136P probably damaging Het
Tenm4 T A 7: 96,544,197 (GRCm39) V2108D probably damaging Het
Trappc10 C T 10: 78,029,235 (GRCm39) V1101M probably benign Het
Ttbk2 C A 2: 120,576,091 (GRCm39) probably null Het
Usp8 A T 2: 126,600,075 (GRCm39) Q998L probably damaging Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Other mutations in Vmn2r80
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Vmn2r80 APN 10 79,030,433 (GRCm39) missense probably damaging 1.00
IGL01325:Vmn2r80 APN 10 79,030,081 (GRCm39) missense possibly damaging 0.62
IGL01611:Vmn2r80 APN 10 79,007,488 (GRCm39) missense probably damaging 1.00
IGL01799:Vmn2r80 APN 10 79,007,385 (GRCm39) missense possibly damaging 0.95
IGL01877:Vmn2r80 APN 10 79,007,334 (GRCm39) splice site probably null
IGL02673:Vmn2r80 APN 10 79,005,318 (GRCm39) missense probably benign 0.02
IGL02756:Vmn2r80 APN 10 79,030,145 (GRCm39) missense probably damaging 1.00
IGL02820:Vmn2r80 APN 10 79,007,439 (GRCm39) missense probably benign 0.04
IGL03382:Vmn2r80 APN 10 79,005,362 (GRCm39) missense probably damaging 1.00
R0071:Vmn2r80 UTSW 10 79,007,566 (GRCm39) missense possibly damaging 0.83
R0071:Vmn2r80 UTSW 10 79,007,566 (GRCm39) missense possibly damaging 0.83
R0129:Vmn2r80 UTSW 10 79,005,330 (GRCm39) missense probably damaging 1.00
R0325:Vmn2r80 UTSW 10 78,984,773 (GRCm39) missense possibly damaging 0.89
R0567:Vmn2r80 UTSW 10 79,030,665 (GRCm39) missense possibly damaging 0.89
R1510:Vmn2r80 UTSW 10 79,005,553 (GRCm39) missense possibly damaging 0.69
R1519:Vmn2r80 UTSW 10 79,030,053 (GRCm39) missense probably damaging 1.00
R1520:Vmn2r80 UTSW 10 79,030,594 (GRCm39) missense probably damaging 1.00
R1627:Vmn2r80 UTSW 10 79,030,249 (GRCm39) missense probably damaging 1.00
R1709:Vmn2r80 UTSW 10 79,030,223 (GRCm39) missense probably benign 0.04
R2116:Vmn2r80 UTSW 10 79,030,558 (GRCm39) missense probably benign 0.09
R2237:Vmn2r80 UTSW 10 79,004,104 (GRCm39) missense probably damaging 1.00
R2308:Vmn2r80 UTSW 10 79,007,455 (GRCm39) missense probably damaging 1.00
R3408:Vmn2r80 UTSW 10 79,004,227 (GRCm39) missense possibly damaging 0.95
R4502:Vmn2r80 UTSW 10 78,984,764 (GRCm39) missense probably benign 0.00
R4685:Vmn2r80 UTSW 10 79,030,162 (GRCm39) missense possibly damaging 0.95
R4851:Vmn2r80 UTSW 10 79,030,156 (GRCm39) missense possibly damaging 0.68
R4947:Vmn2r80 UTSW 10 79,030,532 (GRCm39) missense probably damaging 1.00
R5112:Vmn2r80 UTSW 10 79,030,292 (GRCm39) missense possibly damaging 0.61
R5217:Vmn2r80 UTSW 10 79,004,980 (GRCm39) missense possibly damaging 0.62
R5226:Vmn2r80 UTSW 10 79,029,874 (GRCm39) missense probably benign 0.36
R5512:Vmn2r80 UTSW 10 79,004,066 (GRCm39) missense probably benign 0.00
R5618:Vmn2r80 UTSW 10 78,984,755 (GRCm39) missense probably benign
R5959:Vmn2r80 UTSW 10 79,005,313 (GRCm39) missense probably benign 0.00
R6104:Vmn2r80 UTSW 10 78,984,854 (GRCm39) missense probably benign 0.00
R6110:Vmn2r80 UTSW 10 79,017,837 (GRCm39) missense probably damaging 1.00
R6270:Vmn2r80 UTSW 10 79,030,159 (GRCm39) missense probably benign 0.00
R6508:Vmn2r80 UTSW 10 79,030,290 (GRCm39) missense probably benign 0.03
R6843:Vmn2r80 UTSW 10 79,005,502 (GRCm39) missense probably benign 0.08
R6894:Vmn2r80 UTSW 10 79,005,438 (GRCm39) missense probably benign 0.06
R7048:Vmn2r80 UTSW 10 79,030,153 (GRCm39) missense probably damaging 1.00
R7149:Vmn2r80 UTSW 10 79,030,654 (GRCm39) missense probably benign 0.00
R7262:Vmn2r80 UTSW 10 79,005,579 (GRCm39) missense probably damaging 0.98
R7559:Vmn2r80 UTSW 10 79,030,459 (GRCm39) missense probably benign 0.00
R7622:Vmn2r80 UTSW 10 79,030,097 (GRCm39) missense probably damaging 1.00
R8003:Vmn2r80 UTSW 10 78,984,711 (GRCm39) missense probably benign 0.16
R8207:Vmn2r80 UTSW 10 79,030,150 (GRCm39) nonsense probably null
R8330:Vmn2r80 UTSW 10 79,007,550 (GRCm39) missense probably damaging 1.00
R8337:Vmn2r80 UTSW 10 78,984,707 (GRCm39) missense probably benign 0.00
R8354:Vmn2r80 UTSW 10 78,984,710 (GRCm39) missense probably benign
R8688:Vmn2r80 UTSW 10 79,004,069 (GRCm39) missense probably damaging 1.00
R8903:Vmn2r80 UTSW 10 79,017,928 (GRCm39) missense probably damaging 1.00
R9088:Vmn2r80 UTSW 10 79,005,378 (GRCm39) missense probably benign 0.05
R9125:Vmn2r80 UTSW 10 78,984,760 (GRCm39) missense probably benign 0.12
R9147:Vmn2r80 UTSW 10 79,030,687 (GRCm39) missense probably damaging 0.98
R9148:Vmn2r80 UTSW 10 79,030,687 (GRCm39) missense probably damaging 0.98
R9187:Vmn2r80 UTSW 10 79,030,438 (GRCm39) missense probably benign 0.20
R9218:Vmn2r80 UTSW 10 79,030,270 (GRCm39) missense possibly damaging 0.61
R9553:Vmn2r80 UTSW 10 78,984,743 (GRCm39) missense probably benign
R9612:Vmn2r80 UTSW 10 79,030,712 (GRCm39) missense probably damaging 1.00
R9677:Vmn2r80 UTSW 10 78,984,672 (GRCm39) missense probably benign 0.15
R9769:Vmn2r80 UTSW 10 79,005,443 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r80 UTSW 10 79,030,441 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r80 UTSW 10 79,030,232 (GRCm39) missense possibly damaging 0.65
Z1176:Vmn2r80 UTSW 10 79,005,311 (GRCm39) missense not run
Z1176:Vmn2r80 UTSW 10 79,030,605 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r80 UTSW 10 79,005,311 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- AAGGATCCCTGAAAACGTCTC -3'
(R):5'- ATATATGGAGCCTCGTGATGAG -3'

Sequencing Primer
(F):5'- GGATCCCTGAAAACGTCTCTAGATG -3'
(R):5'- CGTGATGAGAAATACTTGGGAAAATG -3'
Posted On 2015-01-23