Mutagenetix > Incidental Mutation

Incidental Mutation 'R2893:Psma5-ps'

260676

Institutional Source

Beutler Lab

Gene Symbol

Psma5-ps

Ensembl Gene

ENSMUSG00000050490

Gene Name

proteasome subunit alpha 5, pseudogene

Synonyms

Gm8394

MMRRC Submission

040481-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.905) question?

Stock #

R2893 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85149352-85150303 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to C at 85149848 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000079684

SMART Domains

Protein: ENSMUSP00000078625
Gene: ENSMUSG00000050490

Domain	Start	End	E-Value	Type
Proteasome_A_N	8	30	6.32e-8	SMART
Pfam:Proteasome	31	220	5.6e-57	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	C	T	6: 128,557,349 (GRCm39)	A115T	probably benign	Het
Abl1	T	G	2: 31,687,624 (GRCm39)	S521R	probably benign	Het
Acox3	A	G	5: 35,757,192 (GRCm39)	I344V	probably benign	Het
Ank2	T	C	3: 127,041,892 (GRCm39)		probably null	Het
Atoh8	A	T	6: 72,211,856 (GRCm39)	F98Y	probably benign	Het
Caskin2	C	T	11: 115,692,103 (GRCm39)	G894E	probably benign	Het
Cdh15	G	A	8: 123,583,374 (GRCm39)	R59H	probably benign	Het
Cdk5rap2	T	C	4: 70,208,110 (GRCm39)	K779E	probably benign	Het
Csmd2	T	A	4: 128,432,786 (GRCm39)		probably null	Het
Cubn	T	C	2: 13,362,950 (GRCm39)	D1687G	possibly damaging	Het
F11	A	G	8: 45,701,675 (GRCm39)	S353P	probably damaging	Het
Faap100	T	C	11: 120,265,451 (GRCm39)	D475G	probably damaging	Het
Fhip2a	C	T	19: 57,372,601 (GRCm39)	P617L	probably benign	Het
Gm13090	T	A	4: 151,175,157 (GRCm39)	L78*	probably null	Het
Ikbke	G	A	1: 131,197,961 (GRCm39)	P382S	probably damaging	Het
Il4i1	A	G	7: 44,487,414 (GRCm39)	I130V	probably damaging	Het
Islr2	A	T	9: 58,105,149 (GRCm39)	S704T	probably damaging	Het
Itga10	A	G	3: 96,562,416 (GRCm39)	N733D	probably benign	Het
Itih2	C	T	2: 10,107,008 (GRCm39)	G662D	possibly damaging	Het
Kansl1l	T	C	1: 66,840,493 (GRCm39)	Q269R	probably damaging	Het
Kcnj3	A	T	2: 55,337,027 (GRCm39)	I298F	probably damaging	Het
Kdr	A	G	5: 76,107,496 (GRCm39)	F1016L	probably damaging	Het
Miga2	A	T	2: 30,268,306 (GRCm39)		probably null	Het
Or51ai2	A	T	7: 103,587,389 (GRCm39)	R267S	probably damaging	Het
Per2	C	A	1: 91,373,325 (GRCm39)	Q154H	probably damaging	Het
Pik3ap1	G	A	19: 41,364,500 (GRCm39)	A73V	probably benign	Het
Plod3	G	C	5: 137,017,000 (GRCm39)	A50P	probably benign	Het
Rad18	G	A	6: 112,652,734 (GRCm39)	Q288*	probably null	Het
Rapsn	A	T	2: 90,867,169 (GRCm39)	D157V	probably damaging	Het
Slc2a8	A	T	2: 32,864,966 (GRCm39)	W394R	probably damaging	Het
Srcap	T	C	7: 127,138,237 (GRCm39)	S1136P	probably damaging	Het
Tenm4	T	A	7: 96,544,197 (GRCm39)	V2108D	probably damaging	Het
Trappc10	C	T	10: 78,029,235 (GRCm39)	V1101M	probably benign	Het
Ttbk2	C	A	2: 120,576,091 (GRCm39)		probably null	Het
Usp8	A	T	2: 126,600,075 (GRCm39)	Q998L	probably damaging	Het
Vmn2r114	ATTT	ATT	17: 23,509,906 (GRCm39)		probably null	Het
Vmn2r80	T	C	10: 78,984,699 (GRCm39)	F17S	possibly damaging	Het

Other mutations in Psma5-ps

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01336:Psma5-ps	APN	10	85,150,028 (GRCm39)	exon	noncoding transcript
IGL01467:Psma5-ps	APN	10	85,149,986 (GRCm39)	exon	noncoding transcript
IGL02638:Psma5-ps	APN	10	85,149,698 (GRCm39)	exon	noncoding transcript
IGL03253:Psma5-ps	APN	10	85,149,556 (GRCm39)	exon	noncoding transcript
R1929:Psma5-ps	UTSW	10	85,149,595 (GRCm39)	exon	noncoding transcript
R2271:Psma5-ps	UTSW	10	85,149,595 (GRCm39)	exon	noncoding transcript
R4689:Psma5-ps	UTSW	10	85,150,065 (GRCm39)	exon	noncoding transcript
R4711:Psma5-ps	UTSW	10	85,149,667 (GRCm39)	exon	noncoding transcript
R5537:Psma5-ps	UTSW	10	85,149,913 (GRCm39)	exon	noncoding transcript
R5934:Psma5-ps	UTSW	10	85,150,145 (GRCm39)	exon	noncoding transcript
T0722:Psma5-ps	UTSW	10	85,149,457 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- AGCCTAGCAGCATTGAGAAG -3'
(R):5'- TGGCCTCCTTCAGAGTCATAG -3'

Sequencing Primer
(F):5'- AGTGGGCTAATTGCTGATGCTAAAAC -3'
(R):5'- CTCCTTCAGAGTCATAGACTTATGG -3'

Posted On

2015-01-23