Incidental Mutation 'R2894:Olfr847'
ID 260708
Institutional Source Beutler Lab
Gene Symbol Olfr847
Ensembl Gene ENSMUSG00000059821
Gene Name olfactory receptor 847
Synonyms MOR149-2, GA_x6K02T2PVTD-13113073-13112135
MMRRC Submission 040482-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R2894 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19373668-19378669 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 19375292 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 196 (Y196*)
Ref Sequence ENSEMBL: ENSMUSP00000151112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079620] [ENSMUST00000216839]
AlphaFold Q8VFF4
Predicted Effect probably null
Transcript: ENSMUST00000079620
AA Change: Y196*
SMART Domains Protein: ENSMUSP00000078568
Gene: ENSMUSG00000059821
AA Change: Y196*

Pfam:7tm_4 31 308 1.9e-56 PFAM
Pfam:7tm_1 41 290 2.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212306
AA Change: Y196*
Predicted Effect probably null
Transcript: ENSMUST00000216839
AA Change: Y196*
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,580,386 (GRCm38) A115T probably benign Het
Acox3 A G 5: 35,599,848 (GRCm38) I344V probably benign Het
Ank2 T C 3: 127,248,243 (GRCm38) probably null Het
Ccl4 C A 11: 83,663,503 (GRCm38) probably null Het
Cdh15 G A 8: 122,856,635 (GRCm38) R59H probably benign Het
Cdk5rap2 T C 4: 70,289,873 (GRCm38) K779E probably benign Het
Cenpu C A 8: 46,576,349 (GRCm38) N212K probably damaging Het
Dcun1d2 A T 8: 13,278,649 (GRCm38) I86N probably damaging Het
Dnah1 T A 14: 31,298,761 (GRCm38) E1217V possibly damaging Het
Dusp15 T C 2: 152,949,085 (GRCm38) I31V probably benign Het
Ern2 A C 7: 122,181,587 (GRCm38) S114A possibly damaging Het
F11 A G 8: 45,248,638 (GRCm38) S353P probably damaging Het
Fmo6 C T 1: 162,922,724 (GRCm38) W254* probably null Het
Gm16494 T C 17: 47,016,706 (GRCm38) E84G unknown Het
Kdr A G 5: 75,946,836 (GRCm38) F1016L probably damaging Het
Lrrc37a G A 11: 103,497,864 (GRCm38) T2245I unknown Het
Mdga1 T C 17: 29,852,504 (GRCm38) Y381C probably damaging Het
Msh3 G T 13: 92,342,360 (GRCm38) A367D probably benign Het
Nadk A G 4: 155,587,360 (GRCm38) N232S possibly damaging Het
Olfr558 A G 7: 102,709,675 (GRCm38) T139A probably damaging Het
Per2 C A 1: 91,445,603 (GRCm38) Q154H probably damaging Het
Pik3ap1 G A 19: 41,376,061 (GRCm38) A73V probably benign Het
Pramef25 A T 4: 143,949,122 (GRCm38) M378K probably damaging Het
Rad18 G A 6: 112,675,773 (GRCm38) Q288* probably null Het
Rarb T C 14: 16,435,146 (GRCm38) D300G probably damaging Het
Ruvbl1 C T 6: 88,479,132 (GRCm38) R63W possibly damaging Het
Setdb2 T C 14: 59,426,467 (GRCm38) N77S probably benign Het
Slc22a19 C A 19: 7,692,804 (GRCm38) K228N probably benign Het
Thoc6 A G 17: 23,669,035 (GRCm38) S292P probably damaging Het
Tmem126b A T 7: 90,470,913 (GRCm38) S83R probably damaging Het
Tmem232 C T 17: 65,450,413 (GRCm38) E262K probably damaging Het
Vmn2r60 T C 7: 42,135,796 (GRCm38) V144A probably benign Het
Vpreb3 C T 10: 75,943,222 (GRCm38) probably benign Het
Vwa8 A G 14: 79,038,138 (GRCm38) N787S probably damaging Het
Other mutations in Olfr847
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Olfr847 APN 9 19,375,239 (GRCm38) missense probably damaging 1.00
IGL01293:Olfr847 APN 9 19,375,336 (GRCm38) missense probably benign 0.23
IGL01879:Olfr847 APN 9 19,375,407 (GRCm38) nonsense probably null
IGL03298:Olfr847 APN 9 19,375,062 (GRCm38) missense probably damaging 1.00
R1350:Olfr847 UTSW 9 19,375,414 (GRCm38) missense possibly damaging 0.94
R1400:Olfr847 UTSW 9 19,375,062 (GRCm38) missense probably damaging 0.98
R4468:Olfr847 UTSW 9 19,375,648 (GRCm38) missense probably benign 0.00
R4694:Olfr847 UTSW 9 19,375,398 (GRCm38) missense probably damaging 1.00
R4791:Olfr847 UTSW 9 19,375,809 (GRCm38) missense probably benign 0.28
R4794:Olfr847 UTSW 9 19,375,545 (GRCm38) missense probably benign 0.00
R5517:Olfr847 UTSW 9 19,375,767 (GRCm38) missense probably damaging 1.00
R5599:Olfr847 UTSW 9 19,375,629 (GRCm38) missense possibly damaging 0.77
R5777:Olfr847 UTSW 9 19,375,718 (GRCm38) missense probably benign 0.29
R6505:Olfr847 UTSW 9 19,374,941 (GRCm38) makesense probably null
R6509:Olfr847 UTSW 9 19,375,143 (GRCm38) missense probably benign
R7246:Olfr847 UTSW 9 19,375,465 (GRCm38) nonsense probably null
R7659:Olfr847 UTSW 9 19,375,558 (GRCm38) missense probably benign 0.03
R7789:Olfr847 UTSW 9 19,375,065 (GRCm38) missense probably benign 0.33
R7886:Olfr847 UTSW 9 19,375,906 (GRCm38) splice site probably null
R8948:Olfr847 UTSW 9 19,374,966 (GRCm38) missense probably benign 0.03
R9326:Olfr847 UTSW 9 19,375,050 (GRCm38) missense probably damaging 1.00
R9612:Olfr847 UTSW 9 19,375,381 (GRCm38) missense possibly damaging 0.69
R9784:Olfr847 UTSW 9 19,375,820 (GRCm38) missense probably damaging 0.99
R9798:Olfr847 UTSW 9 19,375,281 (GRCm38) missense probably benign 0.30
Z1088:Olfr847 UTSW 9 19,375,684 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-01-23