Incidental Mutation 'R2895:Cmklr2'
ID |
260728 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cmklr2
|
Ensembl Gene |
ENSMUSG00000046856 |
Gene Name |
chemerin chemokine-like receptor 2 |
Synonyms |
Gpr1 |
MMRRC Submission |
040483-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R2895 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
1 |
Chromosomal Location |
63221850-63253702 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 63222321 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Leucine
at position 305
(I305L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000051417
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027108]
[ENSMUST00000050536]
[ENSMUST00000129339]
[ENSMUST00000142062]
[ENSMUST00000188524]
[ENSMUST00000135877]
[ENSMUST00000174890]
|
AlphaFold |
Q8K087 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000027108
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000050536
AA Change: I305L
PolyPhen 2
Score 0.237 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000051417 Gene: ENSMUSG00000046856 AA Change: I305L
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
55 |
302 |
3.9e-40 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000082668
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000082678
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126469
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000126795
|
SMART Domains |
Protein: ENSMUSP00000134341 Gene: ENSMUSG00000025967
Domain | Start | End | E-Value | Type |
SCOP:d1aw9_1
|
4 |
62 |
8e-5 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000129339
|
SMART Domains |
Protein: ENSMUSP00000116492 Gene: ENSMUSG00000025967
Domain | Start | End | E-Value | Type |
EF-1_beta_acid
|
103 |
130 |
2.53e-4 |
SMART |
EF1_GNE
|
139 |
225 |
3.86e-44 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000199062
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148553
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000142062
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000188524
|
SMART Domains |
Protein: ENSMUSP00000140895 Gene: ENSMUSG00000025967
Domain | Start | End | E-Value | Type |
EF-1_beta_acid
|
62 |
89 |
1.2e-8 |
SMART |
EF1_GNE
|
98 |
184 |
2.9e-48 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000135877
|
SMART Domains |
Protein: ENSMUSP00000137671 Gene: ENSMUSG00000025967
Domain | Start | End | E-Value | Type |
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000174890
|
SMART Domains |
Protein: ENSMUSP00000133545 Gene: ENSMUSG00000025967
Domain | Start | End | E-Value | Type |
Blast:WHEP
|
3 |
64 |
3e-6 |
BLAST |
SCOP:d1aw9_1
|
7 |
65 |
2e-4 |
SMART |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 45 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca6 |
A |
G |
11: 110,093,252 (GRCm39) |
V1007A |
probably benign |
Het |
Abhd14b |
C |
T |
9: 106,327,313 (GRCm39) |
R32C |
probably benign |
Het |
Akirin1 |
T |
C |
4: 123,631,864 (GRCm39) |
E168G |
probably damaging |
Het |
Apol7e |
A |
T |
15: 77,598,667 (GRCm39) |
D44V |
possibly damaging |
Het |
Asic1 |
A |
G |
15: 99,594,483 (GRCm39) |
I310V |
probably benign |
Het |
Atp6v0a1 |
A |
G |
11: 100,935,424 (GRCm39) |
H661R |
probably benign |
Het |
Caskin1 |
A |
G |
17: 24,708,016 (GRCm39) |
R25G |
probably damaging |
Het |
Cd96 |
G |
T |
16: 45,938,168 (GRCm39) |
T99K |
probably benign |
Het |
Cep250 |
C |
A |
2: 155,834,042 (GRCm39) |
A1989D |
probably benign |
Het |
Clasp1 |
T |
G |
1: 118,387,568 (GRCm39) |
V78G |
probably damaging |
Het |
Col15a1 |
T |
C |
4: 47,312,091 (GRCm39) |
V1302A |
possibly damaging |
Het |
Crygs |
C |
T |
16: 22,624,301 (GRCm39) |
G102D |
possibly damaging |
Het |
Cyb5r4 |
C |
T |
9: 86,922,452 (GRCm39) |
Q154* |
probably null |
Het |
Dnah7b |
T |
C |
1: 46,178,901 (GRCm39) |
F858S |
probably damaging |
Het |
Dysf |
G |
A |
6: 84,163,491 (GRCm39) |
|
probably null |
Het |
H3f3a |
C |
T |
1: 180,630,703 (GRCm39) |
R117H |
probably benign |
Het |
Igkv1-135 |
T |
A |
6: 67,587,332 (GRCm39) |
S68T |
probably benign |
Het |
Kmt2d |
G |
A |
15: 98,741,820 (GRCm39) |
|
probably benign |
Het |
Lonp1 |
A |
G |
17: 56,922,562 (GRCm39) |
L688P |
probably damaging |
Het |
Lpar6 |
A |
G |
14: 73,476,716 (GRCm39) |
K226E |
probably damaging |
Het |
Map3k19 |
T |
C |
1: 127,749,835 (GRCm39) |
D968G |
possibly damaging |
Het |
Med16 |
G |
A |
10: 79,739,005 (GRCm39) |
|
probably null |
Het |
Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
Mrps7 |
A |
G |
11: 115,495,865 (GRCm39) |
M98V |
probably benign |
Het |
Ms4a14 |
A |
T |
19: 11,281,595 (GRCm39) |
I321N |
possibly damaging |
Het |
Muc5ac |
A |
G |
7: 141,344,877 (GRCm39) |
D116G |
possibly damaging |
Het |
Neu1 |
A |
G |
17: 35,151,758 (GRCm39) |
D184G |
probably benign |
Het |
Nolc1 |
CCAGCAGCAGCAGCAGCAGCAGCAGC |
CCAGCAGCAGCAGCAGCAGCAGCAGCAGC |
19: 46,069,791 (GRCm39) |
|
probably benign |
Het |
Or11h23 |
T |
C |
14: 50,947,973 (GRCm39) |
F62S |
probably damaging |
Het |
Pcdh19 |
CTGTCTCCTCCA |
C |
X: 132,582,057 (GRCm39) |
|
probably null |
Het |
Pcdh19 |
TGTCTCCTCCACGTC |
TGTC |
X: 132,582,058 (GRCm39) |
|
probably null |
Het |
Plcz1 |
A |
G |
6: 139,968,877 (GRCm39) |
I187T |
possibly damaging |
Het |
Pot1b |
A |
T |
17: 55,994,939 (GRCm39) |
I241N |
probably damaging |
Het |
Ppp4r3c1 |
A |
G |
X: 88,976,005 (GRCm39) |
M64T |
possibly damaging |
Het |
Ptpre |
G |
A |
7: 135,245,587 (GRCm39) |
W11* |
probably null |
Het |
Rgsl1 |
T |
A |
1: 153,703,294 (GRCm39) |
E154V |
probably damaging |
Het |
Rnasel |
T |
C |
1: 153,636,522 (GRCm39) |
I634T |
probably damaging |
Het |
Scn10a |
A |
T |
9: 119,490,467 (GRCm39) |
S492T |
probably benign |
Het |
Sec24d |
T |
A |
3: 123,136,800 (GRCm39) |
V511E |
probably damaging |
Het |
Slc7a1 |
A |
G |
5: 148,277,402 (GRCm39) |
I371T |
probably benign |
Het |
Smg1 |
A |
G |
7: 117,788,366 (GRCm39) |
|
probably benign |
Het |
Sntg2 |
A |
T |
12: 30,276,845 (GRCm39) |
S402R |
probably benign |
Het |
Stfa3 |
C |
A |
16: 36,272,522 (GRCm39) |
L59F |
probably benign |
Het |
Tlr3 |
T |
C |
8: 45,850,629 (GRCm39) |
E756G |
possibly damaging |
Het |
Ttll4 |
T |
A |
1: 74,724,517 (GRCm39) |
H562Q |
possibly damaging |
Het |
|
Other mutations in Cmklr2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00427:Cmklr2
|
APN |
1 |
63,222,497 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01086:Cmklr2
|
APN |
1 |
63,222,650 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01490:Cmklr2
|
APN |
1 |
63,222,455 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02409:Cmklr2
|
APN |
1 |
63,222,875 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02426:Cmklr2
|
APN |
1 |
63,222,827 (GRCm39) |
missense |
probably damaging |
0.97 |
R0218:Cmklr2
|
UTSW |
1 |
63,222,690 (GRCm39) |
missense |
probably benign |
0.25 |
R2088:Cmklr2
|
UTSW |
1 |
63,222,811 (GRCm39) |
splice site |
probably null |
|
R2166:Cmklr2
|
UTSW |
1 |
63,223,107 (GRCm39) |
missense |
probably benign |
|
R2896:Cmklr2
|
UTSW |
1 |
63,222,321 (GRCm39) |
missense |
probably benign |
0.24 |
R5102:Cmklr2
|
UTSW |
1 |
63,222,326 (GRCm39) |
missense |
probably damaging |
0.99 |
R5131:Cmklr2
|
UTSW |
1 |
63,222,840 (GRCm39) |
missense |
probably damaging |
1.00 |
R5471:Cmklr2
|
UTSW |
1 |
63,223,058 (GRCm39) |
missense |
probably damaging |
1.00 |
R5652:Cmklr2
|
UTSW |
1 |
63,222,626 (GRCm39) |
missense |
probably benign |
0.00 |
R6187:Cmklr2
|
UTSW |
1 |
63,222,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R7956:Cmklr2
|
UTSW |
1 |
63,222,665 (GRCm39) |
missense |
probably damaging |
0.99 |
R8953:Cmklr2
|
UTSW |
1 |
63,222,272 (GRCm39) |
missense |
probably damaging |
1.00 |
R9031:Cmklr2
|
UTSW |
1 |
63,223,145 (GRCm39) |
missense |
probably benign |
0.03 |
X0060:Cmklr2
|
UTSW |
1 |
63,222,218 (GRCm39) |
missense |
probably benign |
0.02 |
Z1177:Cmklr2
|
UTSW |
1 |
63,222,798 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTGTGGATCAGAATGCAACCTAATC -3'
(R):5'- ATCCTGTCTGTGGTCATTGC -3'
Sequencing Primer
(F):5'- GGCTCACATGAAAACTTTGCACTG -3'
(R):5'- GCCTTCTTGGTTTGCTGGACC -3'
|
Posted On |
2015-01-23 |