Incidental Mutation 'R2884:Or52b4'
ID 260962
Institutional Source Beutler Lab
Gene Symbol Or52b4
Ensembl Gene ENSMUSG00000073979
Gene Name olfactory receptor family 52 subfamily B member 4
Synonyms MOR31-4, Olfr547, GA_x6K02T2PBJ9-5256044-5256988
MMRRC Submission 040472-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R2884 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 102183956-102184891 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102184439 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 162 (I162V)
Ref Sequence ENSEMBL: ENSMUSP00000095831 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098229]
AlphaFold E9PXN3
Predicted Effect probably benign
Transcript: ENSMUST00000098229
AA Change: I162V

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000095831
Gene: ENSMUSG00000073979
AA Change: I162V

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 1.1e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 277 6.7e-10 PFAM
Pfam:7tm_1 43 294 1.2e-20 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik G T 8: 120,872,250 (GRCm39) E59D possibly damaging Het
Arhgap27 T C 11: 103,251,669 (GRCm39) probably null Het
BC061237 A G 14: 44,738,627 (GRCm39) R9G possibly damaging Het
Brsk1 A G 7: 4,694,122 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cspg4b G T 13: 113,505,725 (GRCm39) A2285S probably benign Het
Cspg4b A T 13: 113,457,216 (GRCm39) Q1087H probably damaging Het
Dnajb5 A T 4: 42,957,355 (GRCm39) D284V probably damaging Het
Dnmt3a A G 12: 3,946,132 (GRCm39) D329G probably damaging Het
Ecd C T 14: 20,370,841 (GRCm39) G626D probably damaging Het
Exoc3l4 A G 12: 111,394,956 (GRCm39) D551G possibly damaging Het
Fam227b A T 2: 125,942,846 (GRCm39) I317N probably benign Het
Fam3c G A 6: 22,329,581 (GRCm39) R49C probably damaging Het
Fcrl5 A G 3: 87,364,698 (GRCm39) Y566C probably damaging Het
Fras1 A G 5: 96,848,127 (GRCm39) N1779S probably benign Het
Gm19965 T A 1: 116,749,313 (GRCm39) N331K probably benign Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
H2ac8 A G 13: 23,755,047 (GRCm39) I79T probably damaging Het
H2-DMa A G 17: 34,356,121 (GRCm39) N41S probably damaging Het
Habp4 A T 13: 64,330,080 (GRCm39) R328S probably benign Het
Hexb C T 13: 97,320,208 (GRCm39) G272D probably damaging Het
Lilrb4a A T 10: 51,367,709 (GRCm39) N84Y probably benign Het
Mtnr1a A G 8: 45,540,305 (GRCm39) T89A probably benign Het
Myh13 T A 11: 67,228,469 (GRCm39) N336K probably benign Het
Naca T C 10: 127,877,547 (GRCm39) probably benign Het
Naif1 C T 2: 32,344,887 (GRCm39) P197L probably benign Het
Nprl3 A G 11: 32,198,163 (GRCm39) L179P probably damaging Het
Nup93 A G 8: 95,030,266 (GRCm39) Y375C probably damaging Het
Pcdha12 G A 18: 37,153,757 (GRCm39) D159N probably damaging Het
Plekhs1 G A 19: 56,459,258 (GRCm39) G39R probably benign Het
Ppp4r3a T C 12: 101,034,936 (GRCm39) E53G probably damaging Het
Prss48 A T 3: 85,904,562 (GRCm39) M212K probably benign Het
Pth A T 7: 112,985,235 (GRCm39) L46Q probably damaging Het
Rin2 A T 2: 145,702,911 (GRCm39) T536S probably benign Het
Setx T G 2: 29,038,637 (GRCm39) C1707W probably damaging Het
Stau2 A T 1: 16,301,290 (GRCm39) F519Y possibly damaging Het
Syne2 T G 12: 76,010,533 (GRCm39) V2481G probably benign Het
Tpte C T 8: 22,825,439 (GRCm39) Q331* probably null Het
Ttn G T 2: 76,730,596 (GRCm39) probably benign Het
Utrn A T 10: 12,615,105 (GRCm39) probably null Het
Vmn2r82 A G 10: 79,232,082 (GRCm39) I694V probably benign Het
Vmn2r88 G A 14: 51,651,391 (GRCm39) C235Y probably damaging Het
Xrn2 T A 2: 146,889,576 (GRCm39) V653E probably damaging Het
Znrf3 A T 11: 5,239,693 (GRCm39) D58E probably damaging Het
Other mutations in Or52b4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Or52b4 APN 7 102,184,140 (GRCm39) missense probably benign 0.31
IGL01522:Or52b4 APN 7 102,184,391 (GRCm39) missense probably damaging 0.97
IGL02182:Or52b4 APN 7 102,184,775 (GRCm39) missense probably benign 0.00
IGL02669:Or52b4 APN 7 102,184,868 (GRCm39) missense probably benign
IGL03139:Or52b4 APN 7 102,184,517 (GRCm39) missense possibly damaging 0.95
FR4976:Or52b4 UTSW 7 102,184,888 (GRCm39) makesense probably null
R1246:Or52b4 UTSW 7 102,184,149 (GRCm39) missense probably damaging 1.00
R3852:Or52b4 UTSW 7 102,184,487 (GRCm39) missense probably benign 0.01
R4686:Or52b4 UTSW 7 102,184,356 (GRCm39) missense probably damaging 1.00
R4879:Or52b4 UTSW 7 102,183,962 (GRCm39) missense probably benign 0.00
R6169:Or52b4 UTSW 7 102,184,479 (GRCm39) missense probably benign 0.02
R6213:Or52b4 UTSW 7 102,184,139 (GRCm39) missense probably damaging 1.00
R7080:Or52b4 UTSW 7 102,184,172 (GRCm39) missense possibly damaging 0.91
R7966:Or52b4 UTSW 7 102,184,623 (GRCm39) missense probably damaging 1.00
R8510:Or52b4 UTSW 7 102,184,170 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCCTGGATCGCTGTATCAC -3'
(R):5'- AGAGCTTTGTGGCGAGCATC -3'

Sequencing Primer
(F):5'- GTATCACTCAGCTCTTCTTCATCCAC -3'
(R):5'- AGCATCCTGGGAAGGCATGC -3'
Posted On 2015-01-23