Incidental Mutation 'R2885:Mzt2'
ID 261029
Institutional Source Beutler Lab
Gene Symbol Mzt2
Ensembl Gene ENSMUSG00000022671
Gene Name mitotic spindle organizing protein 2
Synonyms 2610001E06Rik, 2410018G20Rik, Fam128b
MMRRC Submission 040473-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R2885 (G1)
Quality Score 111
Status Validated
Chromosome 16
Chromosomal Location 15666305-15681233 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 15680780 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 3 (A3E)
Ref Sequence ENSEMBL: ENSMUSP00000155739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023351] [ENSMUST00000117136] [ENSMUST00000229680]
AlphaFold Q9CQ25
Predicted Effect unknown
Transcript: ENSMUST00000023351
AA Change: A3E
SMART Domains Protein: ENSMUSP00000023351
Gene: ENSMUSG00000022671
AA Change: A3E

DomainStartEndE-ValueType
Pfam:MOZART2 1 99 1.4e-38 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000117136
AA Change: A3E
SMART Domains Protein: ENSMUSP00000113832
Gene: ENSMUSG00000022671
AA Change: A3E

DomainStartEndE-ValueType
Pfam:MOZART2 11 98 4.5e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137864
Predicted Effect unknown
Transcript: ENSMUST00000229680
AA Change: A3E
Meta Mutation Damage Score 0.0887 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 A G 7: 80,749,940 (GRCm39) S1453G probably damaging Het
Arhgap27 T C 11: 103,251,669 (GRCm39) probably null Het
Casp1 A T 9: 5,299,851 (GRCm39) H108L probably benign Het
Cerk A G 15: 86,027,084 (GRCm39) F142S probably damaging Het
Cmip A G 8: 118,111,704 (GRCm39) N145S probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cyp4b1 C T 4: 115,492,849 (GRCm39) D287N probably damaging Het
Dlx2 G A 2: 71,375,808 (GRCm39) R172* probably null Het
Dnah11 G A 12: 117,951,162 (GRCm39) Q1145* probably null Het
Dock2 A T 11: 34,580,593 (GRCm39) I659N probably damaging Het
Dync2h1 G C 9: 7,102,329 (GRCm39) F2690L probably damaging Het
Fcrl5 A G 3: 87,364,698 (GRCm39) Y566C probably damaging Het
Ift57 T C 16: 49,584,114 (GRCm39) V289A probably damaging Het
Lrrc46 G A 11: 96,925,806 (GRCm39) R219C probably damaging Het
Mapk1 A G 16: 16,844,309 (GRCm39) N269S probably benign Het
Mrgprb1 A T 7: 48,097,469 (GRCm39) Y148N probably damaging Het
Naif1 C T 2: 32,344,887 (GRCm39) P197L probably benign Het
Obscn A T 11: 58,977,574 (GRCm39) V1959E probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Phf12 T C 11: 77,914,595 (GRCm39) I130T possibly damaging Het
Plekhg3 T C 12: 76,611,735 (GRCm39) V338A probably benign Het
Prl3b1 A T 13: 27,433,505 (GRCm39) N220I probably damaging Het
Rusc2 A G 4: 43,415,456 (GRCm39) Q254R probably benign Het
Ryr1 G T 7: 28,774,223 (GRCm39) R2404S probably damaging Het
Setdb1 A G 3: 95,247,506 (GRCm39) I463T probably benign Het
Setx T G 2: 29,038,637 (GRCm39) C1707W probably damaging Het
Siglec1 A G 2: 130,914,667 (GRCm39) F1483S possibly damaging Het
Sis G A 3: 72,816,506 (GRCm39) P1515S probably benign Het
Sit1 C T 4: 43,483,314 (GRCm39) R50H possibly damaging Het
Smc6 T C 12: 11,326,294 (GRCm39) V97A probably damaging Het
Ttc39d A G 17: 80,524,144 (GRCm39) S268G probably benign Het
Ube2frt A G 12: 36,140,574 (GRCm39) probably benign Het
Utrn A T 10: 12,615,105 (GRCm39) probably null Het
Vmn2r60 T A 7: 41,790,403 (GRCm39) D463E possibly damaging Het
Vmn2r91 A T 17: 18,325,628 (GRCm39) Y82F probably benign Het
Zfp709 A T 8: 72,643,549 (GRCm39) D325V probably benign Het
Znrf3 A T 11: 5,239,693 (GRCm39) D58E probably damaging Het
Other mutations in Mzt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01155:Mzt2 APN 16 15,680,274 (GRCm39) missense possibly damaging 0.57
IGL01688:Mzt2 APN 16 15,680,793 (GRCm39) start gained probably benign
R1962:Mzt2 UTSW 16 15,666,543 (GRCm39) missense probably damaging 0.99
R6192:Mzt2 UTSW 16 15,666,551 (GRCm39) missense probably benign 0.12
R7560:Mzt2 UTSW 16 15,680,669 (GRCm39) missense possibly damaging 0.86
R9106:Mzt2 UTSW 16 15,666,568 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTATGAGCTCAAAGTCCCG -3'
(R):5'- ATCGTCAGGCAGTGATCAGC -3'

Sequencing Primer
(F):5'- GAGCTCAAAGTCCCGACCCC -3'
(R):5'- TCAGGCAGTGATCAGCTTCCC -3'
Posted On 2015-01-23