Incidental Mutation 'R2911:Or5h25'
ID 261269
Institutional Source Beutler Lab
Gene Symbol Or5h25
Ensembl Gene ENSMUSG00000060057
Gene Name olfactory receptor family 5 subfamily H member 25
Synonyms MOR113-7P, MOR183-7P, Olfr1540-ps1, MOR113-7P, GA_x54KRFPKG5P-55338697-55337768, Olfr193
MMRRC Submission 040498-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R2911 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58929988-58930996 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 58930544 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 143 (R143H)
Ref Sequence ENSEMBL: ENSMUSP00000146393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076262] [ENSMUST00000207935] [ENSMUST00000208455]
AlphaFold Q7TS43
Predicted Effect probably benign
Transcript: ENSMUST00000076262
AA Change: R143H

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000075611
Gene: ENSMUSG00000060057
AA Change: R143H

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.3e-48 PFAM
Pfam:7tm_1 41 290 5.4e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207935
Predicted Effect probably benign
Transcript: ENSMUST00000208455
AA Change: R143H

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 A G 16: 20,378,982 (GRCm39) T645A probably damaging Het
Adam10 C T 9: 70,626,005 (GRCm39) S91L probably damaging Het
Ahnak A G 19: 8,989,018 (GRCm39) D3434G probably damaging Het
Ankrd11 A T 8: 123,635,537 (GRCm39) D32E probably damaging Het
Cacna1b A T 2: 24,497,553 (GRCm39) probably null Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cep104 T A 4: 154,079,884 (GRCm39) probably null Het
Clstn2 A G 9: 97,414,775 (GRCm39) V373A probably damaging Het
Cyp2c65 T G 19: 39,076,126 (GRCm39) I359M probably damaging Het
Cyp4a12b A T 4: 115,290,723 (GRCm39) K282* probably null Het
Ddx1 C T 12: 13,281,441 (GRCm39) probably null Het
Dnah7a A T 1: 53,466,983 (GRCm39) probably null Het
Dzip1l T C 9: 99,537,655 (GRCm39) V419A probably benign Het
Epha3 A C 16: 63,472,775 (GRCm39) V370G probably benign Het
Fbxo38 T C 18: 62,652,878 (GRCm39) D523G probably benign Het
Fryl T C 5: 73,207,799 (GRCm39) D2457G probably damaging Het
Gm379 A C X: 107,708,371 (GRCm39) F43V possibly damaging Het
Grhl3 T C 4: 135,286,457 (GRCm39) I75V probably benign Het
Lcp2 G A 11: 34,018,970 (GRCm39) probably null Het
Lipo3 T A 19: 33,556,767 (GRCm39) I220F probably benign Het
Lrp1b T C 2: 41,396,704 (GRCm39) E340G probably benign Het
Lypd8l G A 11: 58,499,252 (GRCm39) Q189* probably null Het
Mbtps1 A G 8: 120,272,776 (GRCm39) I123T possibly damaging Het
Ndc80 A T 17: 71,807,371 (GRCm39) S528R probably benign Het
Odf2l A C 3: 144,830,084 (GRCm39) I19L probably benign Het
Or10d3 T C 9: 39,462,117 (GRCm39) I17V possibly damaging Het
Or7e177 A G 9: 20,211,775 (GRCm39) K94R possibly damaging Het
Pigr A G 1: 130,777,270 (GRCm39) D692G probably damaging Het
Reep2 T C 18: 34,978,743 (GRCm39) probably null Het
Rin3 T G 12: 102,339,843 (GRCm39) S598A probably benign Het
Rreb1 A T 13: 38,132,896 (GRCm39) E1690D probably benign Het
Rubcnl C T 14: 75,278,248 (GRCm39) T344I probably benign Het
Shcbp1l C A 1: 153,304,372 (GRCm39) L144I probably damaging Het
Snx2 C T 18: 53,332,946 (GRCm39) P207S probably damaging Het
Sox17 A T 1: 4,563,354 (GRCm39) D92E probably damaging Het
Spata21 A G 4: 140,830,393 (GRCm39) M288V possibly damaging Het
Sra1 T C 18: 36,809,238 (GRCm39) D273G possibly damaging Het
Syt7 T C 19: 10,420,799 (GRCm39) I448T probably benign Het
Tac1 A G 6: 7,559,097 (GRCm39) probably null Het
Tgs1 C A 4: 3,585,616 (GRCm39) N164K probably benign Het
Tmem72 T A 6: 116,675,292 (GRCm39) I67F possibly damaging Het
Ythdc1 T C 5: 86,964,418 (GRCm39) S88P possibly damaging Het
Other mutations in Or5h25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Or5h25 APN 16 58,930,961 (GRCm39) missense probably benign
IGL01613:Or5h25 APN 16 58,930,284 (GRCm39) missense probably damaging 1.00
IGL02280:Or5h25 APN 16 58,930,695 (GRCm39) missense probably damaging 1.00
IGL02533:Or5h25 APN 16 58,930,047 (GRCm39) missense probably benign
IGL02544:Or5h25 APN 16 58,930,507 (GRCm39) missense probably damaging 1.00
IGL02576:Or5h25 APN 16 58,930,134 (GRCm39) missense probably benign
IGL02719:Or5h25 APN 16 58,930,536 (GRCm39) missense probably benign 0.01
IGL03215:Or5h25 APN 16 58,930,325 (GRCm39) missense possibly damaging 0.46
IGL03272:Or5h25 APN 16 58,930,919 (GRCm39) missense probably benign 0.01
PIT4802001:Or5h25 UTSW 16 58,930,964 (GRCm39) missense probably benign
R0544:Or5h25 UTSW 16 58,930,588 (GRCm39) missense probably benign 0.03
R0783:Or5h25 UTSW 16 58,930,532 (GRCm39) nonsense probably null
R1070:Or5h25 UTSW 16 58,930,182 (GRCm39) missense probably benign 0.08
R1211:Or5h25 UTSW 16 58,930,523 (GRCm39) missense possibly damaging 0.68
R1662:Or5h25 UTSW 16 58,930,967 (GRCm39) missense probably benign 0.00
R1754:Or5h25 UTSW 16 58,930,944 (GRCm39) missense probably benign 0.03
R1765:Or5h25 UTSW 16 58,930,118 (GRCm39) missense probably damaging 1.00
R1937:Or5h25 UTSW 16 58,930,157 (GRCm39) missense probably benign 0.11
R2875:Or5h25 UTSW 16 58,930,165 (GRCm39) missense probably benign 0.01
R2910:Or5h25 UTSW 16 58,930,544 (GRCm39) missense probably benign 0.00
R5084:Or5h25 UTSW 16 58,930,436 (GRCm39) missense possibly damaging 0.90
R5700:Or5h25 UTSW 16 58,930,356 (GRCm39) missense probably damaging 0.99
R7018:Or5h25 UTSW 16 58,930,970 (GRCm39) start codon destroyed probably null 0.98
R7083:Or5h25 UTSW 16 58,930,400 (GRCm39) missense probably damaging 1.00
R7572:Or5h25 UTSW 16 58,930,793 (GRCm39) missense probably damaging 1.00
R7720:Or5h25 UTSW 16 58,930,134 (GRCm39) missense probably benign
R8045:Or5h25 UTSW 16 58,930,402 (GRCm39) missense probably benign 0.01
R8869:Or5h25 UTSW 16 58,930,121 (GRCm39) missense
R8960:Or5h25 UTSW 16 58,930,555 (GRCm39) missense probably benign 0.01
R9045:Or5h25 UTSW 16 58,930,365 (GRCm39) missense probably benign 0.13
R9049:Or5h25 UTSW 16 58,930,763 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGAATACCTGAATTGAGCCAGAG -3'
(R):5'- GTGACACCAAAGATGCTACAAG -3'

Sequencing Primer
(F):5'- TTGAGCCAGAGAAAATAAAGAGCATC -3'
(R):5'- GATGCTACAAGACATTTTTGCCAAG -3'
Posted On 2015-01-23