|Institutional Source||Beutler Lab|
|Gene Name||ubiquitin specific peptidase 36|
|Essential gene?||Probably essential (E-score: 0.964)|
|Stock #||R2899 (G1)|
|Chromosomal Location||118259651-118290244 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||G to A at 118276756 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000122761 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000092382] [ENSMUST00000106296] [ENSMUST00000144153]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||97% (30/31)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
PHENOTYPE: Mice homozygous for a gene trap allele display lethality before implantation and arrest at the morula stage. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Usp36||
(F):5'- ACAGAAATTTGCATAGGAGAACTGC -3'
(R):5'- AACCTGGCCTCACCTGTATC -3'
(F):5'- CAGACAGATGCAAATGTTGGCCTG -3'
(R):5'- CCAGTTGGTGGGTCAGTCAC -3'