Incidental Mutation 'R2899:Or5b101'
ID 261427
Institutional Source Beutler Lab
Gene Symbol Or5b101
Ensembl Gene ENSMUSG00000094755
Gene Name olfactory receptor family 5 subfamily B member 101
Synonyms Olfr1453, GA_x6K02T2RE5P-3357666-3356743, MOR202-6
MMRRC Submission 040487-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R2899 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13004768-13005691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13005058 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 212 (I212F)
Ref Sequence ENSEMBL: ENSMUSP00000085071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087773]
AlphaFold Q8VFX0
Predicted Effect probably damaging
Transcript: ENSMUST00000087773
AA Change: I212F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000085071
Gene: ENSMUSG00000094755
AA Change: I212F

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 6.6e-50 PFAM
Pfam:7tm_1 39 288 2.6e-20 PFAM
Meta Mutation Damage Score 0.3386 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 97% (30/31)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,771,443 (GRCm39) K211E probably benign Het
Amigo3 T C 9: 107,931,353 (GRCm39) S259P probably benign Het
Bahd1 C T 2: 118,746,887 (GRCm39) P169S probably damaging Het
Cd200r4 T C 16: 44,653,728 (GRCm39) I175T probably damaging Het
Cep131 T C 11: 119,962,854 (GRCm39) D425G probably benign Het
Clmp T C 9: 40,693,688 (GRCm39) S302P probably damaging Het
Dusp6 T C 10: 99,099,707 (GRCm39) S52P probably damaging Het
Epha5 T A 5: 84,381,667 (GRCm39) I395F probably damaging Het
F5 A G 1: 164,014,469 (GRCm39) E580G possibly damaging Het
Fbxo3 T A 2: 103,881,480 (GRCm39) Y271N probably damaging Het
Fuca1 G A 4: 135,650,323 (GRCm39) W131* probably null Het
Gdf7 C T 12: 8,348,470 (GRCm39) A276T unknown Het
Limk1 A T 5: 134,717,154 (GRCm39) probably null Het
Lrrc37a G A 11: 103,388,690 (GRCm39) T2245I unknown Het
Neb A G 2: 52,075,335 (GRCm39) I210T probably benign Het
Nf1 T G 11: 79,303,584 (GRCm39) N420K possibly damaging Het
Pask G T 1: 93,262,269 (GRCm39) T197K probably damaging Het
Potefam1 C A 2: 111,051,015 (GRCm39) probably benign Het
Pou4f3 T C 18: 42,528,588 (GRCm39) L177P probably benign Het
Rassf1 G A 9: 107,431,393 (GRCm39) G107R probably null Het
Rdx T C 9: 51,980,211 (GRCm39) probably benign Het
Saraf T C 8: 34,628,385 (GRCm39) L77P probably damaging Het
Syngap1 A G 17: 27,178,959 (GRCm39) E483G probably damaging Het
Tsku T C 7: 98,002,124 (GRCm39) N69S probably damaging Het
Usp36 G A 11: 118,167,582 (GRCm39) probably benign Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Zc3h6 T C 2: 128,844,152 (GRCm39) V232A probably benign Het
Zfp143 T A 7: 109,671,336 (GRCm39) S99R probably damaging Het
Zkscan3 A T 13: 21,578,143 (GRCm39) L219Q probably damaging Het
Other mutations in Or5b101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00914:Or5b101 APN 19 13,004,955 (GRCm39) missense probably damaging 0.98
IGL01137:Or5b101 APN 19 13,005,394 (GRCm39) missense possibly damaging 0.52
IGL01894:Or5b101 APN 19 13,005,649 (GRCm39) missense probably damaging 1.00
IGL02579:Or5b101 APN 19 13,004,892 (GRCm39) missense probably damaging 0.99
PIT4418001:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R0099:Or5b101 UTSW 19 13,005,165 (GRCm39) missense probably damaging 1.00
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0395:Or5b101 UTSW 19 13,005,663 (GRCm39) missense probably damaging 1.00
R0453:Or5b101 UTSW 19 13,005,295 (GRCm39) missense probably damaging 0.97
R0847:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R1227:Or5b101 UTSW 19 13,005,217 (GRCm39) missense probably benign
R1823:Or5b101 UTSW 19 13,005,181 (GRCm39) missense probably benign 0.06
R2509:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2964:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R2965:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R3157:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3158:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3409:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3410:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3411:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3425:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R4018:Or5b101 UTSW 19 13,005,189 (GRCm39) missense probably benign
R4668:Or5b101 UTSW 19 13,005,445 (GRCm39) missense probably benign 0.00
R4805:Or5b101 UTSW 19 13,005,661 (GRCm39) missense probably benign 0.04
R5180:Or5b101 UTSW 19 13,004,776 (GRCm39) missense probably benign 0.01
R5391:Or5b101 UTSW 19 13,005,150 (GRCm39) missense probably damaging 1.00
R5557:Or5b101 UTSW 19 13,005,004 (GRCm39) missense probably benign 0.01
R5740:Or5b101 UTSW 19 13,004,926 (GRCm39) missense probably benign 0.24
R7472:Or5b101 UTSW 19 13,005,439 (GRCm39) missense probably benign
R7832:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R7970:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R8044:Or5b101 UTSW 19 13,004,829 (GRCm39) missense probably damaging 1.00
R8229:Or5b101 UTSW 19 13,005,561 (GRCm39) missense possibly damaging 0.55
R8474:Or5b101 UTSW 19 13,005,357 (GRCm39) missense probably damaging 1.00
R8951:Or5b101 UTSW 19 13,004,827 (GRCm39) missense
R8957:Or5b101 UTSW 19 13,004,881 (GRCm39) missense probably benign 0.03
R9046:Or5b101 UTSW 19 13,005,115 (GRCm39) missense probably benign 0.01
R9059:Or5b101 UTSW 19 13,005,277 (GRCm39) missense probably damaging 1.00
R9131:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R9266:Or5b101 UTSW 19 13,005,648 (GRCm39) missense probably damaging 1.00
R9269:Or5b101 UTSW 19 13,004,994 (GRCm39) missense probably benign
Z1088:Or5b101 UTSW 19 13,005,391 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCAGATGACCATGGTGTAGAAC -3'
(R):5'- ATCTGTGGTTTCCTCAGTGC -3'

Sequencing Primer
(F):5'- CACAGATGCAATTTTGTCAGTGTCC -3'
(R):5'- TCAGTGCTTCCATCTATACTATGG -3'
Posted On 2015-01-23