Incidental Mutation 'R2905:Cuedc2'
ID 261636
Institutional Source Beutler Lab
Gene Symbol Cuedc2
Ensembl Gene ENSMUSG00000036748
Gene Name CUE domain containing 2
Synonyms 3010002G01Rik
MMRRC Submission 040492-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.300) question?
Stock # R2905 (G1)
Quality Score 110
Status Validated
Chromosome 19
Chromosomal Location 46318251-46327141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 46321088 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 15 (V15I)
Ref Sequence ENSEMBL: ENSMUSP00000129589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026256] [ENSMUST00000051234] [ENSMUST00000167861] [ENSMUST00000177667]
AlphaFold Q9CXX9
Predicted Effect probably benign
Transcript: ENSMUST00000026256
SMART Domains Protein: ENSMUSP00000026256
Gene: ENSMUSG00000025226

DomainStartEndE-ValueType
Pfam:F-box 18 63 1.9e-6 PFAM
low complexity region 76 84 N/A INTRINSIC
LRR 113 138 1.01e1 SMART
LRR 139 164 1.89e-1 SMART
LRR 165 190 2.27e-4 SMART
LRR 192 217 3.47e0 SMART
LRR 218 243 2.57e-3 SMART
LRR 244 269 2.05e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000051234
AA Change: V15I

PolyPhen 2 Score 0.161 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000053469
Gene: ENSMUSG00000036748
AA Change: V15I

DomainStartEndE-ValueType
Pfam:CUE 144 183 4.6e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000167861
AA Change: V15I

PolyPhen 2 Score 0.161 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000129589
Gene: ENSMUSG00000036748
AA Change: V15I

DomainStartEndE-ValueType
Pfam:CUE 144 183 5.7e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177667
SMART Domains Protein: ENSMUSP00000137489
Gene: ENSMUSG00000025226

DomainStartEndE-ValueType
Pfam:F-box 18 63 2.1e-6 PFAM
low complexity region 76 84 N/A INTRINSIC
LRR 113 138 1.01e1 SMART
LRR 139 164 1.89e-1 SMART
LRR 165 190 2.27e-4 SMART
LRR 192 217 3.47e0 SMART
LRR 218 243 2.57e-3 SMART
LRR 244 269 2.05e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180538
Meta Mutation Damage Score 0.0685 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ajap1 C A 4: 153,517,284 (GRCm39) R19L probably benign Het
Alk A C 17: 72,292,489 (GRCm39) S496R probably benign Het
Arhgap15 T C 2: 43,953,798 (GRCm39) F175L probably damaging Het
Col12a1 G T 9: 79,559,307 (GRCm39) S1860R probably damaging Het
Dennd3 T A 15: 73,429,495 (GRCm39) L4Q probably damaging Het
Dusp8 T A 7: 141,637,126 (GRCm39) K234* probably null Het
Dzip1l A G 9: 99,545,722 (GRCm39) E657G probably damaging Het
F7 C T 8: 13,084,775 (GRCm39) T267I probably benign Het
Gm9791 T C 3: 34,059,336 (GRCm39) noncoding transcript Het
Hmcn1 A G 1: 150,624,786 (GRCm39) S1040P probably damaging Het
Ift56 T C 6: 38,378,037 (GRCm39) V283A possibly damaging Het
Jtb C G 3: 90,139,799 (GRCm39) P62R probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Ly6m T A 15: 74,751,716 (GRCm39) Y106F probably benign Het
Ly75 A G 2: 60,164,898 (GRCm39) V760A probably benign Het
Nudt4 T G 10: 95,399,571 (GRCm39) K17Q probably benign Het
Or6c217 T C 10: 129,738,269 (GRCm39) I103M possibly damaging Het
Pde4a A T 9: 21,112,645 (GRCm39) T274S probably benign Het
Pou6f1 C T 15: 100,483,839 (GRCm39) V220I probably benign Het
Relch T C 1: 105,619,719 (GRCm39) V316A probably benign Het
Rif1 T C 2: 51,988,516 (GRCm39) S752P probably damaging Het
Ror2 A G 13: 53,286,031 (GRCm39) I73T probably benign Het
Samhd1 A T 2: 156,965,335 (GRCm39) F160Y possibly damaging Het
Tas2r118 A G 6: 23,969,801 (GRCm39) F87L possibly damaging Het
Thop1 T C 10: 80,915,425 (GRCm39) L295P probably damaging Het
Tlr12 A G 4: 128,509,802 (GRCm39) M816T probably damaging Het
Trip12 T C 1: 84,732,064 (GRCm39) N970S probably benign Het
Ttll8 A T 15: 88,798,680 (GRCm39) M685K probably benign Het
Ushbp1 G A 8: 71,840,179 (GRCm39) R491* probably null Het
Other mutations in Cuedc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Cuedc2 APN 19 46,320,359 (GRCm39) missense probably damaging 1.00
IGL01155:Cuedc2 APN 19 46,321,088 (GRCm39) missense probably damaging 1.00
IGL01733:Cuedc2 APN 19 46,321,112 (GRCm39) missense probably damaging 1.00
R1656:Cuedc2 UTSW 19 46,320,427 (GRCm39) missense probably damaging 0.99
R1778:Cuedc2 UTSW 19 46,320,079 (GRCm39) missense probably benign 0.00
R5801:Cuedc2 UTSW 19 46,319,796 (GRCm39) missense probably damaging 0.99
R5874:Cuedc2 UTSW 19 46,319,824 (GRCm39) missense possibly damaging 0.71
R8511:Cuedc2 UTSW 19 46,319,358 (GRCm39) critical splice donor site probably null
R9483:Cuedc2 UTSW 19 46,319,399 (GRCm39) missense probably benign 0.10
R9742:Cuedc2 UTSW 19 46,319,727 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CCATGGTTAAGAGTGCTCGCTG -3'
(R):5'- TTCTAGAGACAGTGCTGGACC -3'

Sequencing Primer
(F):5'- CGCTGTTCTTGCAGGACTCAG -3'
(R):5'- AGACAGTGCTGGACCCTGTC -3'
Posted On 2015-01-23