Incidental Mutation 'R2906:Klra3'
ID 261652
Institutional Source Beutler Lab
Gene Symbol Klra3
Ensembl Gene ENSMUSG00000067591
Gene Name killer cell lectin-like receptor, subfamily A, member 3
Synonyms NK-2.1, Nk2.1, Ly49c, Nk2, 5E6, Ly49C, Nk-2
MMRRC Submission 040493-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R2906 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 130300252-130314537 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 130310302 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 73 (Q73K)
Ref Sequence ENSEMBL: ENSMUSP00000107629 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088017] [ENSMUST00000111998]
AlphaFold Q64329
Predicted Effect probably damaging
Transcript: ENSMUST00000088017
AA Change: Q73K

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000085333
Gene: ENSMUSG00000067591
AA Change: Q73K

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 117 1e-7 BLAST
CLECT 143 258 7.11e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000111998
AA Change: Q73K

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000107629
Gene: ENSMUSG00000067591
AA Change: Q73K

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 117 1e-7 BLAST
CLECT 143 258 7.11e-16 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,353,520 (GRCm39) W690R probably damaging Het
Adgrg6 A G 10: 14,308,694 (GRCm39) I800T probably benign Het
Afg3l2 G A 18: 67,573,292 (GRCm39) T170M probably damaging Het
Ap1b1 T A 11: 4,981,641 (GRCm39) N516K probably damaging Het
Armcx6 A T X: 133,650,199 (GRCm39) C211S probably damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Cd96 T C 16: 45,871,850 (GRCm39) T432A possibly damaging Het
Col13a1 T C 10: 61,696,267 (GRCm39) probably benign Het
Ddx4 G T 13: 112,757,311 (GRCm39) probably benign Het
Dnm1l A T 16: 16,132,175 (GRCm39) S666T probably damaging Het
Duoxa1 C T 2: 122,135,155 (GRCm39) V197M probably benign Het
Gm6430 A T 1: 96,952,554 (GRCm39) noncoding transcript Het
Gtf2a1l G A 17: 89,002,083 (GRCm39) R313H possibly damaging Het
Gucy2c A T 6: 136,685,385 (GRCm39) V852E probably damaging Het
Kcnk1 G T 8: 126,722,538 (GRCm39) V114L probably benign Het
Lax1 A T 1: 133,616,643 (GRCm39) M1K probably null Het
Lce1k T C 3: 92,713,882 (GRCm39) S101G unknown Het
Med12l T C 3: 59,164,503 (GRCm39) L1365P probably damaging Het
Mtx2 T C 2: 74,697,253 (GRCm39) S83P probably damaging Het
Naip2 A C 13: 100,298,504 (GRCm39) C511G probably damaging Het
Nefh A G 11: 4,890,216 (GRCm39) I801T probably benign Het
Or8g24 A G 9: 38,989,669 (GRCm39) V124A probably benign Het
Oxct2b A G 4: 123,010,823 (GRCm39) I248V probably benign Het
Pcdhgb2 A T 18: 37,823,908 (GRCm39) I300F probably damaging Het
Ptprc G A 1: 137,992,272 (GRCm39) A1285V possibly damaging Het
Rassf3 A G 10: 121,250,297 (GRCm39) L172P probably damaging Het
Rbm26 T A 14: 105,380,270 (GRCm39) T516S probably benign Het
Rpusd1 T C 17: 25,949,705 (GRCm39) S292P probably benign Het
Scamp5 A G 9: 57,351,146 (GRCm39) V172A probably damaging Het
Snx25 T C 8: 46,502,560 (GRCm39) probably null Het
Tmprss11g A G 5: 86,640,661 (GRCm39) probably benign Het
Ttll3 G C 6: 113,369,471 (GRCm39) probably benign Het
Uggt2 C T 14: 119,256,919 (GRCm39) S1105N probably benign Het
Usp45 T A 4: 21,834,338 (GRCm39) Y805* probably null Het
Zfp639 T C 3: 32,573,900 (GRCm39) L175P probably damaging Het
Zfp995 T C 17: 22,099,247 (GRCm39) D329G probably benign Het
Other mutations in Klra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Klra3 APN 6 130,304,107 (GRCm39) missense probably benign 0.26
R0004:Klra3 UTSW 6 130,300,650 (GRCm39) missense probably damaging 1.00
R1532:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1533:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1534:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1536:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1547:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1548:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1566:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1567:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R1769:Klra3 UTSW 6 130,307,226 (GRCm39) critical splice acceptor site probably null
R1772:Klra3 UTSW 6 130,300,671 (GRCm39) missense probably benign
R1806:Klra3 UTSW 6 130,304,033 (GRCm39) missense probably damaging 0.99
R2131:Klra3 UTSW 6 130,312,738 (GRCm39) missense probably benign 0.07
R2138:Klra3 UTSW 6 130,310,121 (GRCm39) missense probably benign 0.00
R2152:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R2154:Klra3 UTSW 6 130,310,107 (GRCm39) missense probably benign 0.12
R2907:Klra3 UTSW 6 130,310,302 (GRCm39) missense probably damaging 0.99
R4287:Klra3 UTSW 6 130,311,265 (GRCm39) missense probably benign 0.08
R4732:Klra3 UTSW 6 130,304,095 (GRCm39) missense possibly damaging 0.94
R4733:Klra3 UTSW 6 130,304,095 (GRCm39) missense possibly damaging 0.94
R4829:Klra3 UTSW 6 130,300,579 (GRCm39) missense probably benign 0.05
R5308:Klra3 UTSW 6 130,311,270 (GRCm39) splice site probably null
R6701:Klra3 UTSW 6 130,307,216 (GRCm39) missense probably benign 0.01
R7019:Klra3 UTSW 6 130,304,087 (GRCm39) missense probably damaging 1.00
R7174:Klra3 UTSW 6 130,312,941 (GRCm39) splice site probably null
R8542:Klra3 UTSW 6 130,310,096 (GRCm39) critical splice donor site probably null
R8924:Klra3 UTSW 6 130,312,732 (GRCm39) missense probably benign 0.24
R9235:Klra3 UTSW 6 130,311,218 (GRCm39) nonsense probably null
R9716:Klra3 UTSW 6 130,300,602 (GRCm39) missense probably damaging 1.00
X0052:Klra3 UTSW 6 130,310,143 (GRCm39) missense probably damaging 0.99
Z1176:Klra3 UTSW 6 130,312,684 (GRCm39) nonsense probably null
Z1177:Klra3 UTSW 6 130,307,084 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TGCTACATACCTGTGTCCCG -3'
(R):5'- CAGGCTGTGCTGAAACATAAC -3'

Sequencing Primer
(F):5'- TACATACCTGTGTCCCGTGAGG -3'
(R):5'- GCTGTGCTGAAACATAACAATGC -3'
Posted On 2015-01-23