Incidental Mutation 'R2906:Snx25'
ID 261656
Institutional Source Beutler Lab
Gene Symbol Snx25
Ensembl Gene ENSMUSG00000038291
Gene Name sorting nexin 25
Synonyms LOC382008, SBBI31
MMRRC Submission 040493-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2906 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 46486298-46605196 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 46502560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127640 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041582] [ENSMUST00000041582] [ENSMUST00000110378] [ENSMUST00000110378] [ENSMUST00000170416] [ENSMUST00000170416]
AlphaFold Q3ZT31
Predicted Effect probably null
Transcript: ENSMUST00000041582
SMART Domains Protein: ENSMUSP00000035785
Gene: ENSMUSG00000038291

DomainStartEndE-ValueType
Pfam:PXA 1 163 9e-32 PFAM
RGS 287 401 6.62e-10 SMART
low complexity region 421 438 N/A INTRINSIC
PX 512 624 1.38e-10 SMART
low complexity region 658 663 N/A INTRINSIC
low complexity region 664 676 N/A INTRINSIC
Pfam:Nexin_C 701 808 1.7e-35 PFAM
low complexity region 812 828 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000041582
SMART Domains Protein: ENSMUSP00000035785
Gene: ENSMUSG00000038291

DomainStartEndE-ValueType
Pfam:PXA 1 163 9e-32 PFAM
RGS 287 401 6.62e-10 SMART
low complexity region 421 438 N/A INTRINSIC
PX 512 624 1.38e-10 SMART
low complexity region 658 663 N/A INTRINSIC
low complexity region 664 676 N/A INTRINSIC
Pfam:Nexin_C 701 808 1.7e-35 PFAM
low complexity region 812 828 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000110378
SMART Domains Protein: ENSMUSP00000106007
Gene: ENSMUSG00000038291

DomainStartEndE-ValueType
low complexity region 17 31 N/A INTRINSIC
transmembrane domain 44 66 N/A INTRINSIC
transmembrane domain 78 100 N/A INTRINSIC
Pfam:PXA 145 306 8.7e-30 PFAM
RGS 433 547 6.62e-10 SMART
low complexity region 567 584 N/A INTRINSIC
PX 658 770 1.38e-10 SMART
low complexity region 804 809 N/A INTRINSIC
low complexity region 810 822 N/A INTRINSIC
Pfam:Nexin_C 847 953 1e-28 PFAM
low complexity region 958 974 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000110378
SMART Domains Protein: ENSMUSP00000106007
Gene: ENSMUSG00000038291

DomainStartEndE-ValueType
low complexity region 17 31 N/A INTRINSIC
transmembrane domain 44 66 N/A INTRINSIC
transmembrane domain 78 100 N/A INTRINSIC
Pfam:PXA 145 306 8.7e-30 PFAM
RGS 433 547 6.62e-10 SMART
low complexity region 567 584 N/A INTRINSIC
PX 658 770 1.38e-10 SMART
low complexity region 804 809 N/A INTRINSIC
low complexity region 810 822 N/A INTRINSIC
Pfam:Nexin_C 847 953 1e-28 PFAM
low complexity region 958 974 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136097
Predicted Effect probably null
Transcript: ENSMUST00000170416
SMART Domains Protein: ENSMUSP00000127640
Gene: ENSMUSG00000038291

DomainStartEndE-ValueType
Pfam:PXA 1 163 9e-32 PFAM
RGS 287 401 6.62e-10 SMART
low complexity region 421 438 N/A INTRINSIC
PX 512 624 1.38e-10 SMART
low complexity region 658 663 N/A INTRINSIC
low complexity region 664 676 N/A INTRINSIC
Pfam:Nexin_C 701 808 1.7e-35 PFAM
low complexity region 812 828 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000170416
SMART Domains Protein: ENSMUSP00000127640
Gene: ENSMUSG00000038291

DomainStartEndE-ValueType
Pfam:PXA 1 163 9e-32 PFAM
RGS 287 401 6.62e-10 SMART
low complexity region 421 438 N/A INTRINSIC
PX 512 624 1.38e-10 SMART
low complexity region 658 663 N/A INTRINSIC
low complexity region 664 676 N/A INTRINSIC
Pfam:Nexin_C 701 808 1.7e-35 PFAM
low complexity region 812 828 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176410
Predicted Effect probably benign
Transcript: ENSMUST00000177186
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,353,520 (GRCm39) W690R probably damaging Het
Adgrg6 A G 10: 14,308,694 (GRCm39) I800T probably benign Het
Afg3l2 G A 18: 67,573,292 (GRCm39) T170M probably damaging Het
Ap1b1 T A 11: 4,981,641 (GRCm39) N516K probably damaging Het
Armcx6 A T X: 133,650,199 (GRCm39) C211S probably damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Cd96 T C 16: 45,871,850 (GRCm39) T432A possibly damaging Het
Col13a1 T C 10: 61,696,267 (GRCm39) probably benign Het
Ddx4 G T 13: 112,757,311 (GRCm39) probably benign Het
Dnm1l A T 16: 16,132,175 (GRCm39) S666T probably damaging Het
Duoxa1 C T 2: 122,135,155 (GRCm39) V197M probably benign Het
Gm6430 A T 1: 96,952,554 (GRCm39) noncoding transcript Het
Gtf2a1l G A 17: 89,002,083 (GRCm39) R313H possibly damaging Het
Gucy2c A T 6: 136,685,385 (GRCm39) V852E probably damaging Het
Kcnk1 G T 8: 126,722,538 (GRCm39) V114L probably benign Het
Klra3 G T 6: 130,310,302 (GRCm39) Q73K probably damaging Het
Lax1 A T 1: 133,616,643 (GRCm39) M1K probably null Het
Lce1k T C 3: 92,713,882 (GRCm39) S101G unknown Het
Med12l T C 3: 59,164,503 (GRCm39) L1365P probably damaging Het
Mtx2 T C 2: 74,697,253 (GRCm39) S83P probably damaging Het
Naip2 A C 13: 100,298,504 (GRCm39) C511G probably damaging Het
Nefh A G 11: 4,890,216 (GRCm39) I801T probably benign Het
Or8g24 A G 9: 38,989,669 (GRCm39) V124A probably benign Het
Oxct2b A G 4: 123,010,823 (GRCm39) I248V probably benign Het
Pcdhgb2 A T 18: 37,823,908 (GRCm39) I300F probably damaging Het
Ptprc G A 1: 137,992,272 (GRCm39) A1285V possibly damaging Het
Rassf3 A G 10: 121,250,297 (GRCm39) L172P probably damaging Het
Rbm26 T A 14: 105,380,270 (GRCm39) T516S probably benign Het
Rpusd1 T C 17: 25,949,705 (GRCm39) S292P probably benign Het
Scamp5 A G 9: 57,351,146 (GRCm39) V172A probably damaging Het
Tmprss11g A G 5: 86,640,661 (GRCm39) probably benign Het
Ttll3 G C 6: 113,369,471 (GRCm39) probably benign Het
Uggt2 C T 14: 119,256,919 (GRCm39) S1105N probably benign Het
Usp45 T A 4: 21,834,338 (GRCm39) Y805* probably null Het
Zfp639 T C 3: 32,573,900 (GRCm39) L175P probably damaging Het
Zfp995 T C 17: 22,099,247 (GRCm39) D329G probably benign Het
Other mutations in Snx25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Snx25 APN 8 46,491,513 (GRCm39) missense probably damaging 1.00
IGL01432:Snx25 APN 8 46,558,197 (GRCm39) missense probably damaging 0.96
IGL01600:Snx25 APN 8 46,569,347 (GRCm39) missense probably benign 0.00
IGL02150:Snx25 APN 8 46,569,318 (GRCm39) missense possibly damaging 0.89
IGL02386:Snx25 APN 8 46,494,386 (GRCm39) missense possibly damaging 0.93
IGL02691:Snx25 APN 8 46,558,302 (GRCm39) missense possibly damaging 0.88
IGL03338:Snx25 APN 8 46,498,247 (GRCm39) missense probably benign 0.04
IGL03377:Snx25 APN 8 46,533,338 (GRCm39) unclassified probably benign
duo UTSW 8 46,577,119 (GRCm39) start codon destroyed probably null 0.88
R0047:Snx25 UTSW 8 46,494,402 (GRCm39) missense probably damaging 0.99
R0047:Snx25 UTSW 8 46,494,402 (GRCm39) missense probably damaging 0.99
R0048:Snx25 UTSW 8 46,558,146 (GRCm39) splice site probably benign
R0048:Snx25 UTSW 8 46,558,146 (GRCm39) splice site probably benign
R0056:Snx25 UTSW 8 46,491,550 (GRCm39) missense probably damaging 1.00
R0546:Snx25 UTSW 8 46,556,667 (GRCm39) missense probably benign 0.00
R0791:Snx25 UTSW 8 46,577,119 (GRCm39) start codon destroyed probably null 0.88
R1165:Snx25 UTSW 8 46,488,752 (GRCm39) missense probably damaging 0.99
R1255:Snx25 UTSW 8 46,569,275 (GRCm39) missense probably benign 0.13
R1262:Snx25 UTSW 8 46,558,328 (GRCm39) missense probably damaging 0.98
R1522:Snx25 UTSW 8 46,577,119 (GRCm39) start codon destroyed probably null 0.88
R1652:Snx25 UTSW 8 46,502,510 (GRCm39) missense probably damaging 0.99
R1710:Snx25 UTSW 8 46,569,244 (GRCm39) missense possibly damaging 0.69
R1829:Snx25 UTSW 8 46,488,669 (GRCm39) missense possibly damaging 0.82
R2090:Snx25 UTSW 8 46,509,150 (GRCm39) missense probably damaging 1.00
R2158:Snx25 UTSW 8 46,494,444 (GRCm39) missense probably damaging 1.00
R4244:Snx25 UTSW 8 46,558,291 (GRCm39) missense probably damaging 0.98
R4394:Snx25 UTSW 8 46,488,715 (GRCm39) missense probably damaging 1.00
R4465:Snx25 UTSW 8 46,521,266 (GRCm39) missense possibly damaging 0.78
R4586:Snx25 UTSW 8 46,569,474 (GRCm39) intron probably benign
R4663:Snx25 UTSW 8 46,488,616 (GRCm39) missense probably damaging 1.00
R4961:Snx25 UTSW 8 46,521,229 (GRCm39) missense probably damaging 0.99
R5104:Snx25 UTSW 8 46,521,203 (GRCm39) makesense probably null
R5634:Snx25 UTSW 8 46,494,428 (GRCm39) missense possibly damaging 0.94
R6128:Snx25 UTSW 8 46,558,240 (GRCm39) missense probably benign 0.01
R6344:Snx25 UTSW 8 46,488,675 (GRCm39) nonsense probably null
R6382:Snx25 UTSW 8 46,509,028 (GRCm39) missense probably benign
R6523:Snx25 UTSW 8 46,508,892 (GRCm39) missense probably damaging 0.96
R6798:Snx25 UTSW 8 46,486,810 (GRCm39) missense probably damaging 0.98
R7143:Snx25 UTSW 8 46,488,752 (GRCm39) missense possibly damaging 0.92
R7147:Snx25 UTSW 8 46,558,233 (GRCm39) missense probably damaging 0.98
R7519:Snx25 UTSW 8 46,569,309 (GRCm39) missense probably damaging 1.00
R7723:Snx25 UTSW 8 46,491,516 (GRCm39) missense probably damaging 1.00
R9084:Snx25 UTSW 8 46,521,203 (GRCm39) makesense probably null
R9519:Snx25 UTSW 8 46,486,783 (GRCm39) missense probably damaging 1.00
RF002:Snx25 UTSW 8 46,569,218 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGCAATGATACCTCTGCGC -3'
(R):5'- TTGTCCCTGGGCATTCTTAGTTAA -3'

Sequencing Primer
(F):5'- CAATGATACCTCTGCGCTGGTG -3'
(R):5'- TTCCAGGCCATGAACTTAGG -3'
Posted On 2015-01-23