Incidental Mutation 'R2906:Rassf3'
ID 261663
Institutional Source Beutler Lab
Gene Symbol Rassf3
Ensembl Gene ENSMUSG00000025795
Gene Name Ras association (RalGDS/AF-6) domain family member 3
Synonyms
MMRRC Submission 040493-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R2906 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 121246255-121312220 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121250297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 172 (L172P)
Ref Sequence ENSEMBL: ENSMUSP00000026902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026902]
AlphaFold Q99P51
Predicted Effect probably damaging
Transcript: ENSMUST00000026902
AA Change: L172P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000026902
Gene: ENSMUSG00000025795
AA Change: L172P

DomainStartEndE-ValueType
low complexity region 14 26 N/A INTRINSIC
RA 78 181 1.98e-3 SMART
Pfam:Nore1-SARAH 186 225 1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219500
Meta Mutation Damage Score 0.8787 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 97% (37/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,353,520 (GRCm39) W690R probably damaging Het
Adgrg6 A G 10: 14,308,694 (GRCm39) I800T probably benign Het
Afg3l2 G A 18: 67,573,292 (GRCm39) T170M probably damaging Het
Ap1b1 T A 11: 4,981,641 (GRCm39) N516K probably damaging Het
Armcx6 A T X: 133,650,199 (GRCm39) C211S probably damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Cd96 T C 16: 45,871,850 (GRCm39) T432A possibly damaging Het
Col13a1 T C 10: 61,696,267 (GRCm39) probably benign Het
Ddx4 G T 13: 112,757,311 (GRCm39) probably benign Het
Dnm1l A T 16: 16,132,175 (GRCm39) S666T probably damaging Het
Duoxa1 C T 2: 122,135,155 (GRCm39) V197M probably benign Het
Gm6430 A T 1: 96,952,554 (GRCm39) noncoding transcript Het
Gtf2a1l G A 17: 89,002,083 (GRCm39) R313H possibly damaging Het
Gucy2c A T 6: 136,685,385 (GRCm39) V852E probably damaging Het
Kcnk1 G T 8: 126,722,538 (GRCm39) V114L probably benign Het
Klra3 G T 6: 130,310,302 (GRCm39) Q73K probably damaging Het
Lax1 A T 1: 133,616,643 (GRCm39) M1K probably null Het
Lce1k T C 3: 92,713,882 (GRCm39) S101G unknown Het
Med12l T C 3: 59,164,503 (GRCm39) L1365P probably damaging Het
Mtx2 T C 2: 74,697,253 (GRCm39) S83P probably damaging Het
Naip2 A C 13: 100,298,504 (GRCm39) C511G probably damaging Het
Nefh A G 11: 4,890,216 (GRCm39) I801T probably benign Het
Or8g24 A G 9: 38,989,669 (GRCm39) V124A probably benign Het
Oxct2b A G 4: 123,010,823 (GRCm39) I248V probably benign Het
Pcdhgb2 A T 18: 37,823,908 (GRCm39) I300F probably damaging Het
Ptprc G A 1: 137,992,272 (GRCm39) A1285V possibly damaging Het
Rbm26 T A 14: 105,380,270 (GRCm39) T516S probably benign Het
Rpusd1 T C 17: 25,949,705 (GRCm39) S292P probably benign Het
Scamp5 A G 9: 57,351,146 (GRCm39) V172A probably damaging Het
Snx25 T C 8: 46,502,560 (GRCm39) probably null Het
Tmprss11g A G 5: 86,640,661 (GRCm39) probably benign Het
Ttll3 G C 6: 113,369,471 (GRCm39) probably benign Het
Uggt2 C T 14: 119,256,919 (GRCm39) S1105N probably benign Het
Usp45 T A 4: 21,834,338 (GRCm39) Y805* probably null Het
Zfp639 T C 3: 32,573,900 (GRCm39) L175P probably damaging Het
Zfp995 T C 17: 22,099,247 (GRCm39) D329G probably benign Het
Other mutations in Rassf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00783:Rassf3 APN 10 121,251,985 (GRCm39) missense probably benign 0.00
IGL01955:Rassf3 APN 10 121,253,027 (GRCm39) missense probably damaging 1.00
BB005:Rassf3 UTSW 10 121,252,984 (GRCm39) splice site probably null
BB015:Rassf3 UTSW 10 121,252,984 (GRCm39) splice site probably null
R0418:Rassf3 UTSW 10 121,253,075 (GRCm39) missense probably benign 0.42
R0467:Rassf3 UTSW 10 121,253,109 (GRCm39) splice site probably benign
R1167:Rassf3 UTSW 10 121,252,159 (GRCm39) missense probably damaging 1.00
R3801:Rassf3 UTSW 10 121,250,271 (GRCm39) missense possibly damaging 0.76
R7146:Rassf3 UTSW 10 121,252,052 (GRCm39) missense probably benign 0.06
R7257:Rassf3 UTSW 10 121,248,924 (GRCm39) nonsense probably null
R7579:Rassf3 UTSW 10 121,312,103 (GRCm39) start gained probably benign
R7928:Rassf3 UTSW 10 121,252,984 (GRCm39) splice site probably null
R8783:Rassf3 UTSW 10 121,253,069 (GRCm39) missense probably benign
R9010:Rassf3 UTSW 10 121,311,991 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGTAAGCTAACTAGGGGTTCAC -3'
(R):5'- ACCTGTTACTGTGGTGTGTCAC -3'

Sequencing Primer
(F):5'- AAGCTAACTAGGGGTTCACTTTGG -3'
(R):5'- GAGAGAGAGATGTGTCCTGTTAC -3'
Posted On 2015-01-23