Incidental Mutation 'R2906:Naip2'
ID 261666
Institutional Source Beutler Lab
Gene Symbol Naip2
Ensembl Gene ENSMUSG00000078945
Gene Name NLR family, apoptosis inhibitory protein 2
Synonyms Naip-rs6, Birc1b, Naip2
MMRRC Submission 040493-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R2906 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 100280571-100338600 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 100298504 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Glycine at position 511 (C511G)
Ref Sequence ENSEMBL: ENSMUSP00000125852 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067975] [ENSMUST00000117913] [ENSMUST00000167986]
AlphaFold Q9QUK4
Predicted Effect probably damaging
Transcript: ENSMUST00000067975
AA Change: C511G

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000070827
Gene: ENSMUSG00000078945
AA Change: C511G

DomainStartEndE-ValueType
BIR 58 129 7.95e-18 SMART
BIR 157 229 5.31e-37 SMART
BIR 276 347 4.22e-31 SMART
Pfam:NACHT 508 662 1.9e-36 PFAM
low complexity region 954 964 N/A INTRINSIC
low complexity region 1116 1126 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000117913
AA Change: C511G

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000113890
Gene: ENSMUSG00000078945
AA Change: C511G

DomainStartEndE-ValueType
BIR 58 129 7.95e-18 SMART
BIR 157 229 5.31e-37 SMART
BIR 276 347 4.22e-31 SMART
Pfam:NACHT 508 662 1.9e-36 PFAM
low complexity region 954 964 N/A INTRINSIC
low complexity region 1116 1126 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000167986
AA Change: C511G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000125852
Gene: ENSMUSG00000078945
AA Change: C511G

DomainStartEndE-ValueType
BIR 58 129 7.95e-18 SMART
BIR 157 229 5.31e-37 SMART
BIR 276 347 4.22e-31 SMART
Pfam:NACHT 508 662 8.6e-35 PFAM
low complexity region 954 964 N/A INTRINSIC
low complexity region 1116 1126 N/A INTRINSIC
Meta Mutation Damage Score 0.3502 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 97% (37/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,353,520 (GRCm39) W690R probably damaging Het
Adgrg6 A G 10: 14,308,694 (GRCm39) I800T probably benign Het
Afg3l2 G A 18: 67,573,292 (GRCm39) T170M probably damaging Het
Ap1b1 T A 11: 4,981,641 (GRCm39) N516K probably damaging Het
Armcx6 A T X: 133,650,199 (GRCm39) C211S probably damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Cd96 T C 16: 45,871,850 (GRCm39) T432A possibly damaging Het
Col13a1 T C 10: 61,696,267 (GRCm39) probably benign Het
Ddx4 G T 13: 112,757,311 (GRCm39) probably benign Het
Dnm1l A T 16: 16,132,175 (GRCm39) S666T probably damaging Het
Duoxa1 C T 2: 122,135,155 (GRCm39) V197M probably benign Het
Gm6430 A T 1: 96,952,554 (GRCm39) noncoding transcript Het
Gtf2a1l G A 17: 89,002,083 (GRCm39) R313H possibly damaging Het
Gucy2c A T 6: 136,685,385 (GRCm39) V852E probably damaging Het
Kcnk1 G T 8: 126,722,538 (GRCm39) V114L probably benign Het
Klra3 G T 6: 130,310,302 (GRCm39) Q73K probably damaging Het
Lax1 A T 1: 133,616,643 (GRCm39) M1K probably null Het
Lce1k T C 3: 92,713,882 (GRCm39) S101G unknown Het
Med12l T C 3: 59,164,503 (GRCm39) L1365P probably damaging Het
Mtx2 T C 2: 74,697,253 (GRCm39) S83P probably damaging Het
Nefh A G 11: 4,890,216 (GRCm39) I801T probably benign Het
Or8g24 A G 9: 38,989,669 (GRCm39) V124A probably benign Het
Oxct2b A G 4: 123,010,823 (GRCm39) I248V probably benign Het
Pcdhgb2 A T 18: 37,823,908 (GRCm39) I300F probably damaging Het
Ptprc G A 1: 137,992,272 (GRCm39) A1285V possibly damaging Het
Rassf3 A G 10: 121,250,297 (GRCm39) L172P probably damaging Het
Rbm26 T A 14: 105,380,270 (GRCm39) T516S probably benign Het
Rpusd1 T C 17: 25,949,705 (GRCm39) S292P probably benign Het
Scamp5 A G 9: 57,351,146 (GRCm39) V172A probably damaging Het
Snx25 T C 8: 46,502,560 (GRCm39) probably null Het
Tmprss11g A G 5: 86,640,661 (GRCm39) probably benign Het
Ttll3 G C 6: 113,369,471 (GRCm39) probably benign Het
Uggt2 C T 14: 119,256,919 (GRCm39) S1105N probably benign Het
Usp45 T A 4: 21,834,338 (GRCm39) Y805* probably null Het
Zfp639 T C 3: 32,573,900 (GRCm39) L175P probably damaging Het
Zfp995 T C 17: 22,099,247 (GRCm39) D329G probably benign Het
Other mutations in Naip2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00515:Naip2 APN 13 100,291,395 (GRCm39) missense probably benign 0.00
IGL00676:Naip2 APN 13 100,289,140 (GRCm39) missense probably damaging 1.00
IGL00870:Naip2 APN 13 100,288,568 (GRCm39) splice site probably benign
IGL00908:Naip2 APN 13 100,297,157 (GRCm39) missense probably benign 0.01
IGL00916:Naip2 APN 13 100,297,939 (GRCm39) missense probably damaging 0.97
IGL00949:Naip2 APN 13 100,298,099 (GRCm39) missense probably damaging 1.00
IGL01010:Naip2 APN 13 100,291,446 (GRCm39) missense probably damaging 0.99
IGL01642:Naip2 APN 13 100,297,445 (GRCm39) missense probably damaging 0.97
IGL01884:Naip2 APN 13 100,325,329 (GRCm39) splice site probably benign
IGL01917:Naip2 APN 13 100,298,591 (GRCm39) missense probably benign 0.00
IGL02015:Naip2 APN 13 100,298,115 (GRCm39) missense possibly damaging 0.57
IGL02315:Naip2 APN 13 100,297,744 (GRCm39) missense probably damaging 1.00
IGL02328:Naip2 APN 13 100,297,877 (GRCm39) missense probably damaging 1.00
IGL02735:Naip2 APN 13 100,296,722 (GRCm39) missense probably damaging 0.99
IGL02738:Naip2 APN 13 100,325,685 (GRCm39) missense probably benign 0.01
IGL02887:Naip2 APN 13 100,298,020 (GRCm39) missense possibly damaging 0.90
IGL02894:Naip2 APN 13 100,320,297 (GRCm39) missense probably benign
IGL02894:Naip2 APN 13 100,297,505 (GRCm39) missense probably damaging 1.00
IGL02974:Naip2 APN 13 100,298,186 (GRCm39) missense probably damaging 1.00
IGL03024:Naip2 APN 13 100,325,862 (GRCm39) missense possibly damaging 0.50
IGL03056:Naip2 APN 13 100,298,795 (GRCm39) missense possibly damaging 0.90
IGL03281:Naip2 APN 13 100,298,128 (GRCm39) missense probably damaging 0.99
R0131:Naip2 UTSW 13 100,320,296 (GRCm39) missense probably benign 0.01
R0131:Naip2 UTSW 13 100,320,296 (GRCm39) missense probably benign 0.01
R0132:Naip2 UTSW 13 100,320,296 (GRCm39) missense probably benign 0.01
R0310:Naip2 UTSW 13 100,285,350 (GRCm39) missense probably damaging 1.00
R0367:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0368:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0422:Naip2 UTSW 13 100,297,621 (GRCm39) missense probably benign 0.10
R0441:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0445:Naip2 UTSW 13 100,298,395 (GRCm39) missense possibly damaging 0.91
R0446:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0464:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0466:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0467:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0486:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0533:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R0853:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R0853:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R0855:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R0855:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R0904:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R0904:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R0906:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R0906:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R0908:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R0908:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R0959:Naip2 UTSW 13 100,291,419 (GRCm39) missense probably benign 0.03
R0959:Naip2 UTSW 13 100,291,386 (GRCm39) missense probably benign 0.01
R0962:Naip2 UTSW 13 100,315,893 (GRCm39) missense probably damaging 1.00
R1024:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1024:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1186:Naip2 UTSW 13 100,298,545 (GRCm39) frame shift probably null
R1186:Naip2 UTSW 13 100,298,489 (GRCm39) missense possibly damaging 0.63
R1217:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1217:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1340:Naip2 UTSW 13 100,325,630 (GRCm39) missense possibly damaging 0.80
R1342:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1342:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1404:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1423:Naip2 UTSW 13 100,291,355 (GRCm39) intron probably benign
R1423:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1423:Naip2 UTSW 13 100,291,386 (GRCm39) missense probably benign 0.01
R1423:Naip2 UTSW 13 100,291,380 (GRCm39) missense possibly damaging 0.59
R1426:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1426:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1472:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1575:Naip2 UTSW 13 100,291,537 (GRCm39) intron probably benign
R1575:Naip2 UTSW 13 100,291,529 (GRCm39) missense probably benign 0.00
R1576:Naip2 UTSW 13 100,291,529 (GRCm39) missense probably benign 0.00
R1576:Naip2 UTSW 13 100,291,537 (GRCm39) intron probably benign
R1599:Naip2 UTSW 13 100,298,489 (GRCm39) missense possibly damaging 0.63
R1640:Naip2 UTSW 13 100,298,489 (GRCm39) missense possibly damaging 0.63
R1641:Naip2 UTSW 13 100,298,489 (GRCm39) missense possibly damaging 0.63
R1642:Naip2 UTSW 13 100,298,489 (GRCm39) missense possibly damaging 0.63
R1643:Naip2 UTSW 13 100,298,489 (GRCm39) missense possibly damaging 0.63
R1644:Naip2 UTSW 13 100,319,437 (GRCm39) missense possibly damaging 0.83
R1681:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1681:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1891:Naip2 UTSW 13 100,291,395 (GRCm39) missense probably benign 0.00
R1913:Naip2 UTSW 13 100,288,665 (GRCm39) critical splice acceptor site probably null
R1937:Naip2 UTSW 13 100,298,368 (GRCm39) missense probably benign 0.00
R1937:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign
R1993:Naip2 UTSW 13 100,298,515 (GRCm39) missense probably benign 0.03
R2001:Naip2 UTSW 13 100,281,096 (GRCm39) missense probably damaging 1.00
R2055:Naip2 UTSW 13 100,315,880 (GRCm39) missense probably benign 0.07
R2198:Naip2 UTSW 13 100,289,100 (GRCm39) missense probably damaging 1.00
R2931:Naip2 UTSW 13 100,291,529 (GRCm39) missense probably benign 0.00
R3014:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R3016:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R3037:Naip2 UTSW 13 100,291,457 (GRCm39) missense probably benign 0.08
R3414:Naip2 UTSW 13 100,325,771 (GRCm39) nonsense probably null
R3437:Naip2 UTSW 13 100,291,419 (GRCm39) missense probably benign 0.03
R3713:Naip2 UTSW 13 100,298,410 (GRCm39) missense probably damaging 1.00
R3806:Naip2 UTSW 13 100,289,142 (GRCm39) missense possibly damaging 0.92
R3847:Naip2 UTSW 13 100,315,940 (GRCm39) missense probably damaging 1.00
R3847:Naip2 UTSW 13 100,315,941 (GRCm39) missense probably damaging 1.00
R3848:Naip2 UTSW 13 100,315,940 (GRCm39) missense probably damaging 1.00
R3848:Naip2 UTSW 13 100,315,941 (GRCm39) missense probably damaging 1.00
R3849:Naip2 UTSW 13 100,315,940 (GRCm39) missense probably damaging 1.00
R3849:Naip2 UTSW 13 100,315,941 (GRCm39) missense probably damaging 1.00
R3850:Naip2 UTSW 13 100,315,940 (GRCm39) missense probably damaging 1.00
R3850:Naip2 UTSW 13 100,315,941 (GRCm39) missense probably damaging 1.00
R3891:Naip2 UTSW 13 100,297,606 (GRCm39) missense probably damaging 0.99
R4419:Naip2 UTSW 13 100,297,133 (GRCm39) missense probably benign 0.03
R4456:Naip2 UTSW 13 100,291,419 (GRCm39) missense probably benign 0.03
R4458:Naip2 UTSW 13 100,291,419 (GRCm39) missense probably benign 0.03
R4689:Naip2 UTSW 13 100,285,320 (GRCm39) missense probably damaging 1.00
R4797:Naip2 UTSW 13 100,298,243 (GRCm39) missense probably damaging 1.00
R4852:Naip2 UTSW 13 100,298,044 (GRCm39) missense probably benign
R4922:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R5135:Naip2 UTSW 13 100,315,948 (GRCm39) missense probably damaging 0.98
R5185:Naip2 UTSW 13 100,325,859 (GRCm39) missense probably damaging 1.00
R5265:Naip2 UTSW 13 100,289,068 (GRCm39) missense probably damaging 1.00
R5451:Naip2 UTSW 13 100,325,368 (GRCm39) missense probably benign 0.12
R5521:Naip2 UTSW 13 100,291,422 (GRCm39) missense probably damaging 1.00
R5737:Naip2 UTSW 13 100,298,362 (GRCm39) missense probably benign 0.38
R6244:Naip2 UTSW 13 100,288,645 (GRCm39) missense probably damaging 1.00
R6478:Naip2 UTSW 13 100,298,549 (GRCm39) missense probably benign
R6480:Naip2 UTSW 13 100,298,549 (GRCm39) missense probably benign
R6481:Naip2 UTSW 13 100,298,549 (GRCm39) missense probably benign
R6490:Naip2 UTSW 13 100,297,193 (GRCm39) missense probably benign
R6653:Naip2 UTSW 13 100,288,644 (GRCm39) missense probably benign 0.00
R6653:Naip2 UTSW 13 100,298,352 (GRCm39) missense probably benign
R6768:Naip2 UTSW 13 100,314,832 (GRCm39) nonsense probably null
R6791:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R6793:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R6890:Naip2 UTSW 13 100,298,549 (GRCm39) missense probably benign
R7036:Naip2 UTSW 13 100,291,529 (GRCm39) missense probably benign 0.00
R7213:Naip2 UTSW 13 100,323,991 (GRCm39) missense probably damaging 1.00
R7342:Naip2 UTSW 13 100,325,864 (GRCm39) missense probably benign 0.09
R7445:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R7572:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R7699:Naip2 UTSW 13 100,296,877 (GRCm39) missense probably benign 0.00
R7840:Naip2 UTSW 13 100,280,917 (GRCm39) missense probably benign 0.14
R7874:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R7874:Naip2 UTSW 13 100,291,459 (GRCm39) missense probably benign 0.00
R8038:Naip2 UTSW 13 100,298,570 (GRCm39) missense probably benign 0.00
R8065:Naip2 UTSW 13 100,325,730 (GRCm39) missense probably damaging 1.00
R8094:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R8166:Naip2 UTSW 13 100,298,515 (GRCm39) missense probably benign 0.03
R8378:Naip2 UTSW 13 100,298,290 (GRCm39) missense probably benign 0.01
R8669:Naip2 UTSW 13 100,325,477 (GRCm39) missense probably benign 0.05
R8691:Naip2 UTSW 13 100,297,676 (GRCm39) missense probably damaging 1.00
R8716:Naip2 UTSW 13 100,280,914 (GRCm39) missense probably benign
R8720:Naip2 UTSW 13 100,298,630 (GRCm39) missense probably benign 0.04
R8888:Naip2 UTSW 13 100,325,644 (GRCm39) missense probably benign 0.01
R8895:Naip2 UTSW 13 100,325,644 (GRCm39) missense probably benign 0.01
R9031:Naip2 UTSW 13 100,314,776 (GRCm39) missense possibly damaging 0.55
R9072:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R9072:Naip2 UTSW 13 100,291,459 (GRCm39) missense probably benign 0.00
R9074:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R9074:Naip2 UTSW 13 100,291,459 (GRCm39) missense probably benign 0.00
R9077:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
R9077:Naip2 UTSW 13 100,291,459 (GRCm39) missense probably benign 0.00
R9176:Naip2 UTSW 13 100,298,707 (GRCm39) missense probably damaging 1.00
R9219:Naip2 UTSW 13 100,297,213 (GRCm39) missense probably benign 0.06
R9358:Naip2 UTSW 13 100,298,080 (GRCm39) missense probably damaging 1.00
R9371:Naip2 UTSW 13 100,298,354 (GRCm39) nonsense probably null
R9414:Naip2 UTSW 13 100,298,243 (GRCm39) missense probably damaging 1.00
R9415:Naip2 UTSW 13 100,298,243 (GRCm39) missense probably damaging 1.00
R9416:Naip2 UTSW 13 100,298,243 (GRCm39) missense probably damaging 1.00
R9708:Naip2 UTSW 13 100,298,087 (GRCm39) missense probably damaging 0.99
V5622:Naip2 UTSW 13 100,291,537 (GRCm39) intron probably benign
V5622:Naip2 UTSW 13 100,291,529 (GRCm39) missense probably benign 0.00
V5622:Naip2 UTSW 13 100,291,529 (GRCm39) missense probably benign 0.00
X0063:Naip2 UTSW 13 100,298,266 (GRCm39) missense probably damaging 1.00
Y5405:Naip2 UTSW 13 100,291,468 (GRCm39) missense probably benign
Z1088:Naip2 UTSW 13 100,298,417 (GRCm39) missense probably benign
Z1176:Naip2 UTSW 13 100,298,417 (GRCm39) missense probably benign
Z1176:Naip2 UTSW 13 100,298,101 (GRCm39) missense probably benign 0.02
Z1177:Naip2 UTSW 13 100,298,417 (GRCm39) missense probably benign
Z1177:Naip2 UTSW 13 100,289,137 (GRCm39) missense possibly damaging 0.65
Z1177:Naip2 UTSW 13 100,299,373 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGGATGATGCTGCTCAGAC -3'
(R):5'- AGCAGCTGAGAGACACCTAC -3'

Sequencing Primer
(F):5'- GATGATGCTGCTCAGACACACTTC -3'
(R):5'- TACACCAAAGCTACTTTCCGC -3'
Posted On 2015-01-23