Incidental Mutation 'R2906:Zfp995'
ID 261673
Institutional Source Beutler Lab
Gene Symbol Zfp995
Ensembl Gene ENSMUSG00000078546
Gene Name zinc finger protein 995
Synonyms 2210404O09Rik
MMRRC Submission 040493-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R2906 (G1)
Quality Score 206
Status Validated
Chromosome 17
Chromosomal Location 22098551-22128907 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22099247 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 329 (D329G)
Ref Sequence ENSEMBL: ENSMUSP00000139581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106026] [ENSMUST00000190066]
AlphaFold E9Q6M3
Predicted Effect probably benign
Transcript: ENSMUST00000106026
AA Change: D329G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000101647
Gene: ENSMUSG00000078546
AA Change: D329G

DomainStartEndE-ValueType
KRAB 13 76 8.19e-20 SMART
ZnF_C2H2 183 205 8.81e-2 SMART
ZnF_C2H2 211 233 3.21e-4 SMART
ZnF_C2H2 239 261 4.72e-2 SMART
ZnF_C2H2 267 289 1.98e-4 SMART
ZnF_C2H2 295 317 5.59e-4 SMART
ZnF_C2H2 323 345 4.24e-4 SMART
ZnF_C2H2 351 373 9.73e-4 SMART
ZnF_C2H2 379 401 5.29e-5 SMART
ZnF_C2H2 407 429 8.02e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000190066
AA Change: D329G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000139581
Gene: ENSMUSG00000078546
AA Change: D329G

DomainStartEndE-ValueType
KRAB 13 76 8.19e-20 SMART
ZnF_C2H2 183 205 8.81e-2 SMART
ZnF_C2H2 211 233 3.21e-4 SMART
ZnF_C2H2 239 261 4.72e-2 SMART
ZnF_C2H2 267 289 1.98e-4 SMART
ZnF_C2H2 295 317 5.59e-4 SMART
ZnF_C2H2 323 345 4.24e-4 SMART
ZnF_C2H2 351 373 9.73e-4 SMART
ZnF_C2H2 379 401 5.29e-5 SMART
ZnF_C2H2 407 429 8.02e-5 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,353,520 (GRCm39) W690R probably damaging Het
Adgrg6 A G 10: 14,308,694 (GRCm39) I800T probably benign Het
Afg3l2 G A 18: 67,573,292 (GRCm39) T170M probably damaging Het
Ap1b1 T A 11: 4,981,641 (GRCm39) N516K probably damaging Het
Armcx6 A T X: 133,650,199 (GRCm39) C211S probably damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Cd96 T C 16: 45,871,850 (GRCm39) T432A possibly damaging Het
Col13a1 T C 10: 61,696,267 (GRCm39) probably benign Het
Ddx4 G T 13: 112,757,311 (GRCm39) probably benign Het
Dnm1l A T 16: 16,132,175 (GRCm39) S666T probably damaging Het
Duoxa1 C T 2: 122,135,155 (GRCm39) V197M probably benign Het
Gm6430 A T 1: 96,952,554 (GRCm39) noncoding transcript Het
Gtf2a1l G A 17: 89,002,083 (GRCm39) R313H possibly damaging Het
Gucy2c A T 6: 136,685,385 (GRCm39) V852E probably damaging Het
Kcnk1 G T 8: 126,722,538 (GRCm39) V114L probably benign Het
Klra3 G T 6: 130,310,302 (GRCm39) Q73K probably damaging Het
Lax1 A T 1: 133,616,643 (GRCm39) M1K probably null Het
Lce1k T C 3: 92,713,882 (GRCm39) S101G unknown Het
Med12l T C 3: 59,164,503 (GRCm39) L1365P probably damaging Het
Mtx2 T C 2: 74,697,253 (GRCm39) S83P probably damaging Het
Naip2 A C 13: 100,298,504 (GRCm39) C511G probably damaging Het
Nefh A G 11: 4,890,216 (GRCm39) I801T probably benign Het
Or8g24 A G 9: 38,989,669 (GRCm39) V124A probably benign Het
Oxct2b A G 4: 123,010,823 (GRCm39) I248V probably benign Het
Pcdhgb2 A T 18: 37,823,908 (GRCm39) I300F probably damaging Het
Ptprc G A 1: 137,992,272 (GRCm39) A1285V possibly damaging Het
Rassf3 A G 10: 121,250,297 (GRCm39) L172P probably damaging Het
Rbm26 T A 14: 105,380,270 (GRCm39) T516S probably benign Het
Rpusd1 T C 17: 25,949,705 (GRCm39) S292P probably benign Het
Scamp5 A G 9: 57,351,146 (GRCm39) V172A probably damaging Het
Snx25 T C 8: 46,502,560 (GRCm39) probably null Het
Tmprss11g A G 5: 86,640,661 (GRCm39) probably benign Het
Ttll3 G C 6: 113,369,471 (GRCm39) probably benign Het
Uggt2 C T 14: 119,256,919 (GRCm39) S1105N probably benign Het
Usp45 T A 4: 21,834,338 (GRCm39) Y805* probably null Het
Zfp639 T C 3: 32,573,900 (GRCm39) L175P probably damaging Het
Other mutations in Zfp995
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01800:Zfp995 APN 17 22,099,972 (GRCm39) missense possibly damaging 0.64
experienced UTSW 17 22,106,321 (GRCm39) start codon destroyed probably damaging 0.98
R2906_Zfp995_673 UTSW 17 22,099,247 (GRCm39) missense probably benign 0.00
wise UTSW 17 22,099,493 (GRCm39) missense probably benign 0.06
R1164:Zfp995 UTSW 17 22,098,960 (GRCm39) missense probably damaging 1.00
R1167:Zfp995 UTSW 17 22,098,960 (GRCm39) missense probably damaging 1.00
R1592:Zfp995 UTSW 17 22,106,321 (GRCm39) start codon destroyed probably damaging 0.98
R1669:Zfp995 UTSW 17 22,098,945 (GRCm39) missense probably benign 0.12
R1883:Zfp995 UTSW 17 22,099,622 (GRCm39) missense probably benign 0.00
R2044:Zfp995 UTSW 17 22,099,575 (GRCm39) missense probably damaging 1.00
R4454:Zfp995 UTSW 17 22,098,932 (GRCm39) missense probably benign 0.17
R4670:Zfp995 UTSW 17 22,106,320 (GRCm39) start codon destroyed probably null 1.00
R5265:Zfp995 UTSW 17 22,099,604 (GRCm39) missense possibly damaging 0.55
R5393:Zfp995 UTSW 17 22,099,473 (GRCm39) missense probably benign 0.01
R5585:Zfp995 UTSW 17 22,106,339 (GRCm39) splice site probably benign
R5735:Zfp995 UTSW 17 22,101,010 (GRCm39) missense probably benign 0.05
R6243:Zfp995 UTSW 17 22,099,269 (GRCm39) missense probably damaging 1.00
R6318:Zfp995 UTSW 17 22,099,493 (GRCm39) missense probably benign 0.06
R7311:Zfp995 UTSW 17 22,099,641 (GRCm39) missense probably benign 0.01
R7472:Zfp995 UTSW 17 22,099,181 (GRCm39) missense probably damaging 1.00
R7529:Zfp995 UTSW 17 22,099,333 (GRCm39) nonsense probably null
R7765:Zfp995 UTSW 17 22,100,984 (GRCm39) missense probably damaging 1.00
R8156:Zfp995 UTSW 17 22,099,115 (GRCm39) missense probably damaging 1.00
R8995:Zfp995 UTSW 17 22,099,172 (GRCm39) missense probably benign 0.00
Z1176:Zfp995 UTSW 17 22,101,035 (GRCm39) missense possibly damaging 0.57
Predicted Primers PCR Primer
(F):5'- GCACATGTCACATTCACATTTGTAA -3'
(R):5'- AATGTTCCAAATGTTTTGCCCA -3'

Sequencing Primer
(F):5'- ACTCTCTGGTGGACATTAAGACTGC -3'
(R):5'- CCAAATGTTTTGCCCAGAAATGCTG -3'
Posted On 2015-01-23