Incidental Mutation 'R2907:Nek10'
ID 261706
Institutional Source Beutler Lab
Gene Symbol Nek10
Ensembl Gene ENSMUSG00000042567
Gene Name NIMA (never in mitosis gene a)- related kinase 10
Synonyms LOC238944
MMRRC Submission 040494-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2907 (G1)
Quality Score 181
Status Validated
Chromosome 14
Chromosomal Location 7457704-7666183 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 14980613 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 990 (Q990K)
Ref Sequence ENSEMBL: ENSMUSP00000153142 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112630] [ENSMUST00000112631] [ENSMUST00000224491]
AlphaFold Q3UGM2
Predicted Effect possibly damaging
Transcript: ENSMUST00000112630
AA Change: Q990K

PolyPhen 2 Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000108249
Gene: ENSMUSG00000042567
AA Change: Q990K

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000112631
AA Change: Q1001K

PolyPhen 2 Score 0.504 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000108250
Gene: ENSMUSG00000042567
AA Change: Q1001K

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000136826
SMART Domains Protein: ENSMUSP00000123151
Gene: ENSMUSG00000042567

DomainStartEndE-ValueType
Pfam:Pkinase 1 87 5.1e-13 PFAM
Pfam:Pkinase_Tyr 1 87 4.2e-8 PFAM
low complexity region 103 115 N/A INTRINSIC
low complexity region 143 167 N/A INTRINSIC
low complexity region 212 230 N/A INTRINSIC
low complexity region 257 268 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000224491
AA Change: Q990K

PolyPhen 2 Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.3204 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6b A G 5: 137,565,559 (GRCm39) E385G probably damaging Het
Adam32 A T 8: 25,353,520 (GRCm39) W690R probably damaging Het
Ap1b1 T A 11: 4,981,641 (GRCm39) N516K probably damaging Het
Arap3 G A 18: 38,123,580 (GRCm39) P452L possibly damaging Het
Armcx6 A T X: 133,650,199 (GRCm39) C211S probably damaging Het
Asns A G 6: 7,675,506 (GRCm39) S499P probably benign Het
Aspn G T 13: 49,705,374 (GRCm39) V79F probably damaging Het
Astn2 A G 4: 65,563,093 (GRCm39) I844T possibly damaging Het
Asxl3 A T 18: 22,650,330 (GRCm39) H773L possibly damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Bcl6 G A 16: 23,786,869 (GRCm39) R641W probably damaging Het
Csmd3 T A 15: 47,874,449 (GRCm39) I612F probably damaging Het
Dnm1l A T 16: 16,132,175 (GRCm39) S666T probably damaging Het
Gucy2c A T 6: 136,685,385 (GRCm39) V852E probably damaging Het
H2-T3 G A 17: 36,498,347 (GRCm39) R233C possibly damaging Het
Igfbp4 A G 11: 98,932,377 (GRCm39) probably benign Het
Igkv16-104 T C 6: 68,402,911 (GRCm39) I68T probably damaging Het
Kansl1 T A 11: 104,315,286 (GRCm39) S251C possibly damaging Het
Kcnk1 G T 8: 126,722,538 (GRCm39) V114L probably benign Het
Klra3 G T 6: 130,310,302 (GRCm39) Q73K probably damaging Het
Mcpt1 T C 14: 56,257,580 (GRCm39) V242A probably damaging Het
Nlrp4d A T 7: 10,112,354 (GRCm39) V605E probably benign Het
Or10w1 C T 19: 13,632,611 (GRCm39) P268S possibly damaging Het
Or5an1b T C 19: 12,300,032 (GRCm39) D53G probably damaging Het
Or5d46 T C 2: 88,170,827 (GRCm39) I306T probably benign Het
Osbpl1a A G 18: 13,004,129 (GRCm39) probably benign Het
Otud4 T A 8: 80,399,697 (GRCm39) S803T probably benign Het
Pax9 C T 12: 56,756,529 (GRCm39) T289I probably benign Het
Pcdha5 A C 18: 37,093,868 (GRCm39) I126L possibly damaging Het
Psmd4 G T 3: 94,941,273 (GRCm39) A55E probably damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rbm26 T A 14: 105,380,270 (GRCm39) T516S probably benign Het
Sdr42e1 G A 8: 118,389,511 (GRCm39) L377F probably damaging Het
Setdb1 T C 3: 95,234,512 (GRCm39) probably benign Het
Uba3 T C 6: 97,180,514 (GRCm39) E21G probably benign Het
Uggt2 C T 14: 119,256,919 (GRCm39) S1105N probably benign Het
Zfp113 T C 5: 138,143,219 (GRCm39) N344D probably benign Het
Zfp738 T C 13: 67,818,231 (GRCm39) I587V probably benign Het
Other mutations in Nek10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01361:Nek10 APN 14 14,850,957 (GRCm38) missense probably damaging 0.99
IGL02067:Nek10 APN 14 14,861,639 (GRCm38) missense probably benign 0.12
IGL02361:Nek10 APN 14 14,843,856 (GRCm38) missense probably damaging 1.00
IGL02687:Nek10 APN 14 14,840,570 (GRCm38) missense probably damaging 1.00
IGL02929:Nek10 APN 14 14,821,119 (GRCm38) missense possibly damaging 0.82
IGL03229:Nek10 APN 14 14,986,686 (GRCm38) missense probably benign 0.10
P0041:Nek10 UTSW 14 14,861,603 (GRCm38) missense probably benign 0.01
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0142:Nek10 UTSW 14 14,861,560 (GRCm38) missense possibly damaging 0.96
R0433:Nek10 UTSW 14 14,860,927 (GRCm38) missense probably benign 0.32
R0633:Nek10 UTSW 14 14,857,782 (GRCm38) critical splice acceptor site probably null
R1087:Nek10 UTSW 14 14,827,059 (GRCm38) missense possibly damaging 0.59
R1184:Nek10 UTSW 14 14,931,325 (GRCm38) splice site probably benign
R1250:Nek10 UTSW 14 14,853,887 (GRCm38) missense probably damaging 1.00
R1371:Nek10 UTSW 14 14,850,983 (GRCm38) missense probably damaging 0.98
R1506:Nek10 UTSW 14 14,999,078 (GRCm38) splice site probably benign
R1829:Nek10 UTSW 14 14,863,454 (GRCm38) critical splice acceptor site probably null
R1831:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1833:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1990:Nek10 UTSW 14 14,860,764 (GRCm38) missense probably benign
R1997:Nek10 UTSW 14 14,827,003 (GRCm38) missense probably benign 0.09
R2011:Nek10 UTSW 14 14,885,122 (GRCm38) missense probably damaging 1.00
R2158:Nek10 UTSW 14 14,885,047 (GRCm38) splice site probably null
R2288:Nek10 UTSW 14 14,853,956 (GRCm38) nonsense probably null
R2568:Nek10 UTSW 14 14,999,112 (GRCm38) missense possibly damaging 0.89
R2965:Nek10 UTSW 14 14,836,202 (GRCm38) missense probably damaging 1.00
R3922:Nek10 UTSW 14 14,861,585 (GRCm38) missense possibly damaging 0.88
R4032:Nek10 UTSW 14 14,853,877 (GRCm38) splice site probably null
R4700:Nek10 UTSW 14 14,842,841 (GRCm38) missense possibly damaging 0.69
R4742:Nek10 UTSW 14 14,861,624 (GRCm38) missense probably null 0.03
R4785:Nek10 UTSW 14 14,855,714 (GRCm38) missense probably benign
R4890:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4891:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4920:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4924:Nek10 UTSW 14 14,846,594 (GRCm38) splice site probably null
R4928:Nek10 UTSW 14 14,930,577 (GRCm38) missense probably damaging 1.00
R4948:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4952:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4953:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R5092:Nek10 UTSW 14 14,820,851 (GRCm38) missense possibly damaging 0.81
R5097:Nek10 UTSW 14 14,857,851 (GRCm38) missense probably benign 0.00
R5593:Nek10 UTSW 14 14,980,544 (GRCm38) nonsense probably null
R5696:Nek10 UTSW 14 14,860,736 (GRCm38) splice site probably null
R5813:Nek10 UTSW 14 14,986,704 (GRCm38) missense probably benign 0.01
R5829:Nek10 UTSW 14 14,865,404 (GRCm38) missense probably damaging 1.00
R5872:Nek10 UTSW 14 14,850,896 (GRCm38) missense probably benign 0.06
R5939:Nek10 UTSW 14 14,931,290 (GRCm38) missense possibly damaging 0.58
R6025:Nek10 UTSW 14 14,865,633 (GRCm38) missense probably benign 0.41
R6235:Nek10 UTSW 14 14,821,113 (GRCm38) nonsense probably null
R6539:Nek10 UTSW 14 14,860,789 (GRCm38) missense possibly damaging 0.94
R6542:Nek10 UTSW 14 14,999,108 (GRCm38) missense probably benign 0.44
R6561:Nek10 UTSW 14 14,828,448 (GRCm38) missense possibly damaging 0.48
R6659:Nek10 UTSW 14 14,861,684 (GRCm38) missense probably benign 0.29
R7039:Nek10 UTSW 14 14,986,700 (GRCm38) missense probably damaging 0.99
R7039:Nek10 UTSW 14 14,826,946 (GRCm38) missense possibly damaging 0.63
R7102:Nek10 UTSW 14 14,828,517 (GRCm38) missense probably damaging 1.00
R7185:Nek10 UTSW 14 14,846,621 (GRCm38) missense probably benign 0.03
R7198:Nek10 UTSW 14 14,850,947 (GRCm38) missense probably damaging 0.99
R7202:Nek10 UTSW 14 14,836,171 (GRCm38) missense probably benign 0.01
R7251:Nek10 UTSW 14 14,853,965 (GRCm38) missense probably benign
R7345:Nek10 UTSW 14 14,955,503 (GRCm38) missense probably benign
R7590:Nek10 UTSW 14 15,006,693 (GRCm38) makesense probably null
R7593:Nek10 UTSW 14 14,826,955 (GRCm38) missense probably benign 0.04
R7616:Nek10 UTSW 14 14,937,759 (GRCm38) missense probably benign 0.27
R7635:Nek10 UTSW 14 14,850,932 (GRCm38) missense probably benign 0.01
R7817:Nek10 UTSW 14 15,001,017 (GRCm38) missense probably benign 0.00
R7826:Nek10 UTSW 14 14,860,846 (GRCm38) splice site probably null
R7986:Nek10 UTSW 14 15,001,020 (GRCm38) missense probably benign 0.17
R8765:Nek10 UTSW 14 14,999,104 (GRCm38) missense probably damaging 0.97
R8856:Nek10 UTSW 14 14,937,610 (GRCm38) missense probably damaging 0.96
R8973:Nek10 UTSW 14 14,931,321 (GRCm38) critical splice donor site probably null
R9002:Nek10 UTSW 14 14,980,590 (GRCm38) missense probably damaging 1.00
R9088:Nek10 UTSW 14 14,931,314 (GRCm38) missense probably damaging 1.00
R9195:Nek10 UTSW 14 14,821,139 (GRCm38) missense probably benign 0.03
R9464:Nek10 UTSW 14 14,937,766 (GRCm38) missense probably benign
R9511:Nek10 UTSW 14 14,828,511 (GRCm38) missense probably benign 0.05
R9529:Nek10 UTSW 14 14,850,833 (GRCm38) missense probably benign
R9590:Nek10 UTSW 14 14,853,888 (GRCm38) missense probably damaging 1.00
Z1177:Nek10 UTSW 14 15,001,157 (GRCm38) nonsense probably null
Z1177:Nek10 UTSW 14 14,853,948 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CATTGTCTCGTCCGTGAGATG -3'
(R):5'- AGAAGCAACCCAGCTCTGTC -3'

Sequencing Primer
(F):5'- GAGATGAGATTTTGGCTTCCTTCTCC -3'
(R):5'- ACGTCTGTTTTAGGATGGAGAAGAC -3'
Posted On 2015-01-23