Incidental Mutation 'R1764:Rb1cc1'
| ID |
261724 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rb1cc1
|
| Ensembl Gene |
ENSMUSG00000025907 |
| Gene Name |
RB1-inducible coiled-coil 1 |
| Synonyms |
Fip200, 2900055E04Rik, 5930404L04Rik, Cc1, LaXp180 |
| MMRRC Submission |
039796-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1764 (G1)
|
| Quality Score |
60 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
6284858-6346599 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to G
at 6284904 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027040]
[ENSMUST00000159906]
[ENSMUST00000160062]
[ENSMUST00000160871]
|
| AlphaFold |
Q9ESK9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027040
|
| SMART Domains |
Protein: ENSMUSP00000027040
Gene: ENSMUSG00000025907
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1euvb_
|
1 |
51 |
7e-4 |
SMART |
|
Blast:UBQ
|
3 |
76 |
8e-12 |
BLAST |
|
low complexity region
|
471 |
486 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
658 |
674 |
N/A |
INTRINSIC |
|
coiled coil region
|
859 |
921 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1045 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1066 |
N/A |
INTRINSIC |
|
SCOP:d1eq1a_
|
1159 |
1305 |
1e-3 |
SMART |
|
low complexity region
|
1374 |
1388 |
N/A |
INTRINSIC |
|
Pfam:ATG11
|
1447 |
1583 |
5.6e-28 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000097832
|
| SMART Domains |
Protein: ENSMUSP00000095443
Gene: ENSMUSG00000073741
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
52 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
141 |
N/A |
INTRINSIC |
|
low complexity region
|
148 |
167 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159618
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159906
|
| SMART Domains |
Protein: ENSMUSP00000125396
Gene: ENSMUSG00000025907
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1euvb_
|
1 |
51 |
5e-6 |
SMART |
|
Blast:UBQ
|
3 |
76 |
3e-15 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160062
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160871
|
| SMART Domains |
Protein: ENSMUSP00000123768
Gene: ENSMUSG00000025907
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1euvb_
|
1 |
51 |
1e-5 |
SMART |
|
Blast:UBQ
|
3 |
76 |
3e-14 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162210
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191825
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 92.2%
|
| Validation Efficiency |
94% (94/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality at mid/late gestation associated with heart failure and liver degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,884,655 (GRCm39) |
V401A |
probably benign |
Het |
| Abca7 |
G |
T |
10: 79,844,784 (GRCm39) |
W1502L |
probably damaging |
Het |
| Adcy7 |
A |
G |
8: 89,035,468 (GRCm39) |
E124G |
probably benign |
Het |
| Aif1l |
G |
A |
2: 31,855,118 (GRCm39) |
E66K |
probably benign |
Het |
| Aldh8a1 |
A |
T |
10: 21,271,392 (GRCm39) |
M373L |
probably benign |
Het |
| Alg6 |
T |
C |
4: 99,629,815 (GRCm39) |
Y131H |
probably benign |
Het |
| Arhgef6 |
T |
C |
X: 56,383,922 (GRCm39) |
M5V |
probably benign |
Het |
| Arrdc4 |
A |
T |
7: 68,391,622 (GRCm39) |
I215K |
probably damaging |
Het |
| Asb4 |
A |
G |
6: 5,390,798 (GRCm39) |
|
probably null |
Het |
| Astn1 |
T |
C |
1: 158,331,821 (GRCm39) |
I305T |
probably benign |
Het |
| Atp5f1b |
T |
A |
10: 127,919,949 (GRCm39) |
|
probably benign |
Het |
| Atp8a1 |
C |
A |
5: 67,788,910 (GRCm39) |
M1044I |
probably benign |
Het |
| Atp9b |
C |
T |
18: 80,952,806 (GRCm39) |
|
probably null |
Het |
| Brd10 |
T |
A |
19: 29,696,560 (GRCm39) |
T978S |
possibly damaging |
Het |
| Btaf1 |
A |
G |
19: 36,928,518 (GRCm39) |
H113R |
probably benign |
Het |
| C87436 |
G |
T |
6: 86,430,594 (GRCm39) |
C338F |
possibly damaging |
Het |
| Casz1 |
T |
C |
4: 149,027,357 (GRCm39) |
|
probably benign |
Het |
| Cbr3 |
T |
A |
16: 93,487,370 (GRCm39) |
H184Q |
probably damaging |
Het |
| Cct8l1 |
T |
C |
5: 25,722,097 (GRCm39) |
S271P |
possibly damaging |
Het |
| Cdc34 |
A |
G |
10: 79,521,174 (GRCm39) |
K77R |
probably benign |
Het |
| Cdc34 |
G |
T |
10: 79,521,172 (GRCm39) |
|
probably null |
Het |
| Cdh20 |
A |
G |
1: 104,862,070 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
A |
G |
9: 108,706,157 (GRCm39) |
E880G |
probably damaging |
Het |
| Cers1 |
T |
G |
8: 70,774,141 (GRCm39) |
|
probably null |
Het |
| Cntn5 |
T |
C |
9: 9,673,988 (GRCm39) |
I705V |
probably benign |
Het |
| Dennd4c |
T |
A |
4: 86,721,247 (GRCm39) |
D636E |
probably damaging |
Het |
| Dnah11 |
T |
C |
12: 118,154,560 (GRCm39) |
E240G |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,314,369 (GRCm39) |
Y4100C |
probably damaging |
Het |
| Dpysl3 |
T |
C |
18: 43,496,583 (GRCm39) |
E151G |
probably damaging |
Het |
| Efcab9 |
T |
G |
11: 32,474,457 (GRCm39) |
T9P |
possibly damaging |
Het |
| Eif4g2 |
A |
T |
7: 110,673,694 (GRCm39) |
F725Y |
probably damaging |
Het |
| Epha6 |
T |
A |
16: 59,596,091 (GRCm39) |
I867F |
probably null |
Het |
| Erbin |
T |
C |
13: 103,979,959 (GRCm39) |
|
probably benign |
Het |
| Evi5l |
A |
G |
8: 4,253,560 (GRCm39) |
E468G |
probably damaging |
Het |
| Filip1l |
C |
T |
16: 57,390,401 (GRCm39) |
R330W |
probably damaging |
Het |
| Fmo3 |
C |
T |
1: 162,786,142 (GRCm39) |
V283M |
possibly damaging |
Het |
| Gabarapl1 |
A |
T |
6: 129,510,481 (GRCm39) |
K24N |
possibly damaging |
Het |
| Gigyf1 |
C |
T |
5: 137,520,770 (GRCm39) |
|
probably benign |
Het |
| Gm5581 |
T |
A |
6: 131,158,362 (GRCm39) |
|
noncoding transcript |
Het |
| Gon4l |
G |
T |
3: 88,799,906 (GRCm39) |
K850N |
probably damaging |
Het |
| Igf2bp3 |
C |
T |
6: 49,085,980 (GRCm39) |
R233H |
probably damaging |
Het |
| Iqcf4 |
G |
A |
9: 106,445,893 (GRCm39) |
R85C |
probably benign |
Het |
| Kalrn |
C |
T |
16: 34,033,243 (GRCm39) |
R473Q |
probably damaging |
Het |
| Lmod2 |
T |
A |
6: 24,603,376 (GRCm39) |
V117E |
probably damaging |
Het |
| Mapk11 |
A |
G |
15: 89,028,594 (GRCm39) |
|
probably null |
Het |
| Mcm3 |
G |
A |
1: 20,876,103 (GRCm39) |
R664C |
probably damaging |
Het |
| Mex3d |
A |
G |
10: 80,222,770 (GRCm39) |
M162T |
probably benign |
Het |
| Mrgprb3 |
A |
G |
7: 48,292,771 (GRCm39) |
I260T |
probably benign |
Het |
| Ncor2 |
G |
T |
5: 125,105,679 (GRCm39) |
A1637D |
possibly damaging |
Het |
| Nedd4 |
T |
A |
9: 72,638,189 (GRCm39) |
D441E |
probably damaging |
Het |
| Nek5 |
A |
T |
8: 22,599,928 (GRCm39) |
C194S |
probably damaging |
Het |
| Nos1ap |
T |
C |
1: 170,146,447 (GRCm39) |
D369G |
possibly damaging |
Het |
| Ntrk1 |
G |
T |
3: 87,687,391 (GRCm39) |
T681K |
probably damaging |
Het |
| Or13a24 |
T |
C |
7: 140,154,383 (GRCm39) |
W106R |
probably damaging |
Het |
| Or4f14 |
A |
G |
2: 111,742,526 (GRCm39) |
F250L |
possibly damaging |
Het |
| Otogl |
C |
T |
10: 107,735,322 (GRCm39) |
W154* |
probably null |
Het |
| Pcdh20 |
T |
C |
14: 88,706,620 (GRCm39) |
T227A |
possibly damaging |
Het |
| Pcdhb17 |
T |
C |
18: 37,620,324 (GRCm39) |
S705P |
probably damaging |
Het |
| Piezo2 |
T |
C |
18: 63,257,713 (GRCm39) |
H335R |
possibly damaging |
Het |
| Pkn2 |
T |
C |
3: 142,499,615 (GRCm39) |
Q954R |
probably damaging |
Het |
| Pramel23 |
C |
A |
4: 143,424,840 (GRCm39) |
C201F |
probably benign |
Het |
| Prkcq |
G |
A |
2: 11,237,442 (GRCm39) |
V74M |
probably damaging |
Het |
| Prkrip1 |
A |
T |
5: 136,218,489 (GRCm39) |
|
probably null |
Het |
| Pttg1ip2 |
A |
T |
5: 5,528,943 (GRCm39) |
I24N |
possibly damaging |
Het |
| Rbm5 |
A |
T |
9: 107,644,763 (GRCm39) |
Y11* |
probably null |
Het |
| Rsf1 |
CG |
CGACGGCGGTG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Het |
| Ryr3 |
C |
A |
2: 112,690,805 (GRCm39) |
V1082L |
probably damaging |
Het |
| Scart2 |
A |
G |
7: 139,877,178 (GRCm39) |
E831G |
probably benign |
Het |
| Sel1l3 |
C |
A |
5: 53,327,789 (GRCm39) |
E497* |
probably null |
Het |
| Serpina6 |
A |
T |
12: 103,620,182 (GRCm39) |
I189N |
probably damaging |
Het |
| Serpinb11 |
A |
T |
1: 107,304,532 (GRCm39) |
T166S |
probably benign |
Het |
| Skint7 |
T |
C |
4: 111,839,270 (GRCm39) |
L188S |
probably benign |
Het |
| Slc25a45 |
C |
T |
19: 5,934,958 (GRCm39) |
A269V |
probably damaging |
Het |
| Sltm |
A |
G |
9: 70,469,082 (GRCm39) |
T114A |
probably benign |
Het |
| Sned1 |
G |
A |
1: 93,209,376 (GRCm39) |
V830M |
possibly damaging |
Het |
| Spen |
C |
A |
4: 141,200,261 (GRCm39) |
V2766L |
probably damaging |
Het |
| Srgap2 |
T |
A |
1: 131,247,275 (GRCm39) |
I445F |
possibly damaging |
Het |
| Stox2 |
A |
T |
8: 47,647,051 (GRCm39) |
Y200* |
probably null |
Het |
| Strada |
C |
A |
11: 106,055,010 (GRCm39) |
R384L |
probably damaging |
Het |
| Tctn2 |
G |
A |
5: 124,757,094 (GRCm39) |
|
noncoding transcript |
Het |
| Tgfbr3l |
G |
T |
8: 4,299,282 (GRCm39) |
R461L |
probably benign |
Het |
| Tmem65 |
A |
G |
15: 58,661,998 (GRCm39) |
|
probably benign |
Het |
| Tpst1 |
G |
T |
5: 130,143,343 (GRCm39) |
V294F |
possibly damaging |
Het |
| Trim23 |
A |
G |
13: 104,335,126 (GRCm39) |
Y384C |
probably damaging |
Het |
| Ube3b |
C |
G |
5: 114,542,678 (GRCm39) |
L512V |
possibly damaging |
Het |
| Ubxn4 |
T |
A |
1: 128,183,916 (GRCm39) |
V92E |
probably damaging |
Het |
| Vmn2r57 |
A |
T |
7: 41,050,067 (GRCm39) |
C561S |
probably damaging |
Het |
| Vwa8 |
A |
G |
14: 79,145,635 (GRCm39) |
D104G |
probably damaging |
Het |
| Wdr25 |
T |
A |
12: 108,992,364 (GRCm39) |
L73* |
probably null |
Het |
| Wnt9a |
G |
A |
11: 59,221,728 (GRCm39) |
A209T |
probably benign |
Het |
| Zcchc17 |
A |
C |
4: 130,223,388 (GRCm39) |
C133G |
probably damaging |
Het |
| Zdhhc18 |
T |
A |
4: 133,335,987 (GRCm39) |
M375L |
probably benign |
Het |
| Zfhx3 |
T |
C |
8: 109,678,276 (GRCm39) |
F3109L |
probably benign |
Het |
| Zfp202 |
T |
A |
9: 40,121,762 (GRCm39) |
D286E |
probably benign |
Het |
| Zzef1 |
T |
C |
11: 72,784,158 (GRCm39) |
L2021P |
probably benign |
Het |
|
| Other mutations in Rb1cc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00489:Rb1cc1
|
APN |
1 |
6,319,730 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00590:Rb1cc1
|
APN |
1 |
6,308,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00678:Rb1cc1
|
APN |
1 |
6,304,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00705:Rb1cc1
|
APN |
1 |
6,314,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00957:Rb1cc1
|
APN |
1 |
6,319,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01363:Rb1cc1
|
APN |
1 |
6,320,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01599:Rb1cc1
|
APN |
1 |
6,318,995 (GRCm39) |
nonsense |
probably null |
|
|
IGL01610:Rb1cc1
|
APN |
1 |
6,318,705 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01929:Rb1cc1
|
APN |
1 |
6,310,383 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01978:Rb1cc1
|
APN |
1 |
6,308,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02312:Rb1cc1
|
APN |
1 |
6,335,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02471:Rb1cc1
|
APN |
1 |
6,310,275 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02677:Rb1cc1
|
APN |
1 |
6,319,643 (GRCm39) |
missense |
probably benign |
|
|
IGL02702:Rb1cc1
|
APN |
1 |
6,310,247 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02816:Rb1cc1
|
APN |
1 |
6,333,052 (GRCm39) |
splice site |
probably benign |
|
|
IGL02899:Rb1cc1
|
APN |
1 |
6,334,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
fingerling
|
UTSW |
1 |
6,331,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
tots
|
UTSW |
1 |
6,315,861 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02988:Rb1cc1
|
UTSW |
1 |
6,318,035 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0020:Rb1cc1
|
UTSW |
1 |
6,334,772 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0254:Rb1cc1
|
UTSW |
1 |
6,333,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0390:Rb1cc1
|
UTSW |
1 |
6,318,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Rb1cc1
|
UTSW |
1 |
6,333,491 (GRCm39) |
splice site |
probably null |
|
|
R0482:Rb1cc1
|
UTSW |
1 |
6,310,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Rb1cc1
|
UTSW |
1 |
6,319,395 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0512:Rb1cc1
|
UTSW |
1 |
6,318,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0616:Rb1cc1
|
UTSW |
1 |
6,314,486 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0617:Rb1cc1
|
UTSW |
1 |
6,319,014 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0837:Rb1cc1
|
UTSW |
1 |
6,304,495 (GRCm39) |
splice site |
probably null |
|
|
R1399:Rb1cc1
|
UTSW |
1 |
6,320,042 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1532:Rb1cc1
|
UTSW |
1 |
6,319,958 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1542:Rb1cc1
|
UTSW |
1 |
6,314,473 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1746:Rb1cc1
|
UTSW |
1 |
6,333,237 (GRCm39) |
splice site |
probably null |
|
|
R1968:Rb1cc1
|
UTSW |
1 |
6,318,419 (GRCm39) |
splice site |
probably null |
|
|
R2025:Rb1cc1
|
UTSW |
1 |
6,315,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Rb1cc1
|
UTSW |
1 |
6,320,262 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2101:Rb1cc1
|
UTSW |
1 |
6,319,559 (GRCm39) |
missense |
probably benign |
|
|
R2249:Rb1cc1
|
UTSW |
1 |
6,342,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3176:Rb1cc1
|
UTSW |
1 |
6,319,590 (GRCm39) |
missense |
probably benign |
|
|
R3276:Rb1cc1
|
UTSW |
1 |
6,319,590 (GRCm39) |
missense |
probably benign |
|
|
R3716:Rb1cc1
|
UTSW |
1 |
6,340,914 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3747:Rb1cc1
|
UTSW |
1 |
6,318,966 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3850:Rb1cc1
|
UTSW |
1 |
6,320,337 (GRCm39) |
missense |
probably benign |
0.22 |
|
R3967:Rb1cc1
|
UTSW |
1 |
6,318,494 (GRCm39) |
splice site |
probably benign |
|
|
R3969:Rb1cc1
|
UTSW |
1 |
6,318,494 (GRCm39) |
splice site |
probably benign |
|
|
R3972:Rb1cc1
|
UTSW |
1 |
6,319,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4166:Rb1cc1
|
UTSW |
1 |
6,335,887 (GRCm39) |
intron |
probably benign |
|
|
R4168:Rb1cc1
|
UTSW |
1 |
6,300,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4358:Rb1cc1
|
UTSW |
1 |
6,315,861 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4370:Rb1cc1
|
UTSW |
1 |
6,318,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4869:Rb1cc1
|
UTSW |
1 |
6,285,245 (GRCm39) |
intron |
probably benign |
|
|
R4945:Rb1cc1
|
UTSW |
1 |
6,319,851 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5111:Rb1cc1
|
UTSW |
1 |
6,284,858 (GRCm39) |
intron |
probably benign |
|
|
R5175:Rb1cc1
|
UTSW |
1 |
6,318,545 (GRCm39) |
missense |
probably benign |
|
|
R5196:Rb1cc1
|
UTSW |
1 |
6,304,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5271:Rb1cc1
|
UTSW |
1 |
6,319,417 (GRCm39) |
nonsense |
probably null |
|
|
R5341:Rb1cc1
|
UTSW |
1 |
6,285,266 (GRCm39) |
intron |
probably benign |
|
|
R5952:Rb1cc1
|
UTSW |
1 |
6,318,406 (GRCm39) |
missense |
probably benign |
|
|
R5992:Rb1cc1
|
UTSW |
1 |
6,304,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6054:Rb1cc1
|
UTSW |
1 |
6,320,058 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6064:Rb1cc1
|
UTSW |
1 |
6,319,958 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6313:Rb1cc1
|
UTSW |
1 |
6,314,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6345:Rb1cc1
|
UTSW |
1 |
6,333,481 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6488:Rb1cc1
|
UTSW |
1 |
6,340,951 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6566:Rb1cc1
|
UTSW |
1 |
6,319,316 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6739:Rb1cc1
|
UTSW |
1 |
6,304,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6829:Rb1cc1
|
UTSW |
1 |
6,319,488 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6945:Rb1cc1
|
UTSW |
1 |
6,331,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6976:Rb1cc1
|
UTSW |
1 |
6,333,126 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7031:Rb1cc1
|
UTSW |
1 |
6,308,690 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7066:Rb1cc1
|
UTSW |
1 |
6,320,229 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7185:Rb1cc1
|
UTSW |
1 |
6,308,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7276:Rb1cc1
|
UTSW |
1 |
6,319,416 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7448:Rb1cc1
|
UTSW |
1 |
6,315,727 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7463:Rb1cc1
|
UTSW |
1 |
6,319,404 (GRCm39) |
missense |
probably benign |
|
|
R7484:Rb1cc1
|
UTSW |
1 |
6,344,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7496:Rb1cc1
|
UTSW |
1 |
6,318,415 (GRCm39) |
missense |
probably null |
0.02 |
|
R7618:Rb1cc1
|
UTSW |
1 |
6,335,782 (GRCm39) |
splice site |
probably null |
|
|
R7681:Rb1cc1
|
UTSW |
1 |
6,310,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7774:Rb1cc1
|
UTSW |
1 |
6,318,309 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7780:Rb1cc1
|
UTSW |
1 |
6,319,138 (GRCm39) |
nonsense |
probably null |
|
|
R7947:Rb1cc1
|
UTSW |
1 |
6,318,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8057:Rb1cc1
|
UTSW |
1 |
6,315,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8094:Rb1cc1
|
UTSW |
1 |
6,333,448 (GRCm39) |
nonsense |
probably null |
|
|
R8527:Rb1cc1
|
UTSW |
1 |
6,315,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8758:Rb1cc1
|
UTSW |
1 |
6,310,451 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8843:Rb1cc1
|
UTSW |
1 |
6,315,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8922:Rb1cc1
|
UTSW |
1 |
6,319,194 (GRCm39) |
missense |
probably benign |
|
|
R8937:Rb1cc1
|
UTSW |
1 |
6,333,441 (GRCm39) |
missense |
probably benign |
|
|
R9018:Rb1cc1
|
UTSW |
1 |
6,319,490 (GRCm39) |
missense |
probably benign |
|
|
R9106:Rb1cc1
|
UTSW |
1 |
6,319,109 (GRCm39) |
missense |
|
|
|
R9127:Rb1cc1
|
UTSW |
1 |
6,333,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Rb1cc1
|
UTSW |
1 |
6,315,109 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9311:Rb1cc1
|
UTSW |
1 |
6,310,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9365:Rb1cc1
|
UTSW |
1 |
6,315,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Rb1cc1
|
UTSW |
1 |
6,314,339 (GRCm39) |
missense |
probably benign |
|
|
R9598:Rb1cc1
|
UTSW |
1 |
6,310,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Rb1cc1
|
UTSW |
1 |
6,318,528 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9659:Rb1cc1
|
UTSW |
1 |
6,318,673 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9799:Rb1cc1
|
UTSW |
1 |
6,315,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Rb1cc1
|
UTSW |
1 |
6,319,242 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACCGAAATACCTTCCAGGGTCAG -3'
(R):5'- AAGGCATCACCTCTAGGTTCCTCC -3'
Sequencing Primer
(F):5'- CTTCCAGGGTCAGGGAAGG -3'
(R):5'- AACCCGTCAGGTGCTGAG -3'
|
| Posted On |
2015-01-26 |
Incidental Mutation