Incidental Mutation 'R0352:Ppp1r16a'
ID 261857
Institutional Source Beutler Lab
Gene Symbol Ppp1r16a
Ensembl Gene ENSMUSG00000033819
Gene Name protein phosphatase 1, regulatory (inhibitor) subunit 16A
Synonyms R75527, Mypt3, 2900084E10Rik
MMRRC Submission 038558-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R0352 (G1)
Quality Score 196
Status Validated
Chromosome 15
Chromosomal Location 76671615-76694919 bp(+) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 76690799 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037551] [ENSMUST00000135388] [ENSMUST00000150399] [ENSMUST00000229679] [ENSMUST00000231028]
AlphaFold Q923M0
Predicted Effect probably benign
Transcript: ENSMUST00000037551
SMART Domains Protein: ENSMUSP00000037356
Gene: ENSMUSG00000033819

DomainStartEndE-ValueType
ANK 70 99 2.5e3 SMART
ANK 103 132 3.41e-3 SMART
ANK 136 165 2.66e-5 SMART
ANK 231 260 2.58e-3 SMART
ANK 264 293 4.03e-5 SMART
low complexity region 323 346 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127674
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129396
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134449
Predicted Effect probably benign
Transcript: ENSMUST00000135388
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138951
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140730
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143274
Predicted Effect probably benign
Transcript: ENSMUST00000150399
SMART Domains Protein: ENSMUSP00000123458
Gene: ENSMUSG00000033819

DomainStartEndE-ValueType
ANK 70 99 2.5e3 SMART
ANK 103 132 3.41e-3 SMART
ANK 136 165 2.66e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000156920
Predicted Effect probably benign
Transcript: ENSMUST00000229679
Predicted Effect probably benign
Transcript: ENSMUST00000231028
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.4%
  • 20x: 90.0%
Validation Efficiency 100% (70/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik C T 12: 71,138,030 (GRCm38) T64M possibly damaging Het
3110040N11Rik G T 7: 81,788,460 (GRCm38) N49K probably benign Het
Adrb1 T A 19: 56,722,861 (GRCm38) F164I probably damaging Het
Aplf C T 6: 87,653,884 (GRCm38) V190I probably benign Het
Aqr A G 2: 114,170,052 (GRCm38) Y50H probably damaging Het
Arfgef3 A C 10: 18,661,387 (GRCm38) I182R probably benign Het
BC080695 A T 4: 143,571,308 (GRCm38) probably benign Het
Cacna1b G A 2: 24,625,232 (GRCm38) probably benign Het
Casp9 A G 4: 141,805,530 (GRCm38) T246A probably damaging Het
Clcn6 A G 4: 148,014,606 (GRCm38) S427P probably damaging Het
Cnga1 T C 5: 72,604,503 (GRCm38) N556S possibly damaging Het
Cntnap2 G A 6: 45,992,084 (GRCm38) probably null Het
Col11a2 T G 17: 34,042,527 (GRCm38) V120G probably benign Het
Cux2 A C 5: 121,884,739 (GRCm38) probably benign Het
Dmrt2 T C 19: 25,678,662 (GRCm38) S542P probably damaging Het
Dnah7b A G 1: 46,277,126 (GRCm38) H3133R probably damaging Het
Drosha G A 15: 12,837,288 (GRCm38) R286Q unknown Het
Eipr1 A G 12: 28,766,785 (GRCm38) D47G probably damaging Het
Fam192a A G 8: 94,588,011 (GRCm38) F73S probably damaging Het
Fras1 T G 5: 96,726,540 (GRCm38) Y2275D probably damaging Het
Gm13083 A T 4: 143,615,989 (GRCm38) D222V possibly damaging Het
Grm4 C T 17: 27,451,891 (GRCm38) probably benign Het
Hebp1 A G 6: 135,152,920 (GRCm38) V100A possibly damaging Het
Hivep2 G A 10: 14,143,295 (GRCm38) V1937I possibly damaging Het
Hs3st6 T C 17: 24,758,194 (GRCm38) V216A probably damaging Het
Hsd17b4 T C 18: 50,191,784 (GRCm38) I688T probably benign Het
Hydin T C 8: 110,569,901 (GRCm38) probably null Het
Iws1 A G 18: 32,084,205 (GRCm38) E426G probably damaging Het
Klrb1f T C 6: 129,053,717 (GRCm38) S64P probably damaging Het
Lacc1 C T 14: 77,035,189 (GRCm38) G56R probably damaging Het
Lcmt2 A G 2: 121,138,896 (GRCm38) S569P probably benign Het
Lipm C T 19: 34,112,875 (GRCm38) probably benign Het
Lum A G 10: 97,568,609 (GRCm38) H122R probably damaging Het
Magi2 A G 5: 20,065,666 (GRCm38) Y15C probably damaging Het
Mal A T 2: 127,640,366 (GRCm38) I39N probably damaging Het
Mgme1 A G 2: 144,276,399 (GRCm38) H197R probably benign Het
Mmrn1 A T 6: 60,944,971 (GRCm38) K137N probably benign Het
Myh3 T A 11: 67,090,428 (GRCm38) C706S possibly damaging Het
Myo18b A T 5: 112,874,523 (GRCm38) probably benign Het
Myom1 A G 17: 71,045,749 (GRCm38) E356G possibly damaging Het
Nfib A G 4: 82,504,717 (GRCm38) probably benign Het
Npc1l1 T C 11: 6,223,076 (GRCm38) M788V probably benign Het
Olfr459 C T 6: 41,772,124 (GRCm38) M58I probably damaging Het
Pdha2 A G 3: 141,211,696 (GRCm38) V17A probably benign Het
Pgap1 A T 1: 54,486,458 (GRCm38) probably benign Het
Polr1a G T 6: 71,920,763 (GRCm38) probably benign Het
Prmt2 A T 10: 76,208,503 (GRCm38) V405D possibly damaging Het
Psg26 T A 7: 18,475,256 (GRCm38) Y409F probably benign Het
Ptges G T 2: 30,903,132 (GRCm38) Y29* probably null Het
Ptrhd1 A G 12: 4,236,399 (GRCm38) T97A probably benign Het
Ripk3 T A 14: 55,786,743 (GRCm38) probably benign Het
Rnf114 A T 2: 167,511,216 (GRCm38) I136F probably benign Het
Serinc5 A G 13: 92,707,989 (GRCm38) probably null Het
Slc17a3 C T 13: 23,855,858 (GRCm38) S293F probably damaging Het
Slc23a2 C A 2: 132,060,796 (GRCm38) M495I probably benign Het
Slc52a3 T A 2: 152,007,513 (GRCm38) L360* probably null Het
Snapc1 C T 12: 73,975,032 (GRCm38) R81C probably damaging Het
Syt5 A G 7: 4,541,171 (GRCm38) V290A probably benign Het
Szt2 G A 4: 118,382,593 (GRCm38) A1931V unknown Het
Tasp1 A G 2: 139,951,458 (GRCm38) probably null Het
Tcp10a C A 17: 7,326,406 (GRCm38) D43E probably damaging Het
Tnfsf11 A T 14: 78,278,968 (GRCm38) Y187N probably benign Het
Tppp2 T A 14: 51,919,350 (GRCm38) N61K possibly damaging Het
Wwtr1 A T 3: 57,575,127 (GRCm38) W100R probably damaging Het
Zfp623 A G 15: 75,948,584 (GRCm38) D463G probably benign Het
Zfp990 A G 4: 145,536,604 (GRCm38) I57M probably damaging Het
Zmat5 G A 11: 4,722,413 (GRCm38) C10Y probably damaging Het
Other mutations in Ppp1r16a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01393:Ppp1r16a APN 15 76,694,544 (GRCm38) missense probably benign
IGL01449:Ppp1r16a APN 15 76,694,294 (GRCm38) unclassified probably benign
IGL02128:Ppp1r16a APN 15 76,693,978 (GRCm38) missense probably benign
IGL02331:Ppp1r16a APN 15 76,691,000 (GRCm38) missense probably benign
R0057:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0060:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0113:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0114:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0244:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0646:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0652:Ppp1r16a UTSW 15 76,690,799 (GRCm38) unclassified probably benign
R0722:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0744:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0833:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0834:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0835:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0836:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0885:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R0942:Ppp1r16a UTSW 15 76,694,011 (GRCm38) missense probably damaging 0.98
R1061:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R1168:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R1170:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R1171:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R1503:Ppp1r16a UTSW 15 76,694,399 (GRCm38) missense probably benign
R1572:Ppp1r16a UTSW 15 76,693,669 (GRCm38) nonsense probably null
R1914:Ppp1r16a UTSW 15 76,693,068 (GRCm38) missense probably damaging 1.00
R1915:Ppp1r16a UTSW 15 76,693,068 (GRCm38) missense probably damaging 1.00
R2085:Ppp1r16a UTSW 15 76,693,596 (GRCm38) missense probably damaging 0.99
R4823:Ppp1r16a UTSW 15 76,693,193 (GRCm38) unclassified probably benign
R5153:Ppp1r16a UTSW 15 76,694,396 (GRCm38) nonsense probably null
R5443:Ppp1r16a UTSW 15 76,694,646 (GRCm38) missense possibly damaging 0.95
R5481:Ppp1r16a UTSW 15 76,691,021 (GRCm38) missense probably damaging 1.00
R6900:Ppp1r16a UTSW 15 76,691,723 (GRCm38) missense probably damaging 1.00
R7165:Ppp1r16a UTSW 15 76,690,904 (GRCm38) missense probably damaging 1.00
R7686:Ppp1r16a UTSW 15 76,694,583 (GRCm38) missense probably benign 0.37
R8138:Ppp1r16a UTSW 15 76,691,721 (GRCm38) missense probably damaging 1.00
R9150:Ppp1r16a UTSW 15 76,690,854 (GRCm38) unclassified probably benign
Predicted Primers
Posted On 2015-02-04