Mutagenetix > Incidental Mutations

Incidental Mutation 'R0411:Cd101'

261877

Institutional Source

Beutler Lab

Gene Symbol

Cd101

Ensembl Gene

ENSMUSG00000086564

Gene Name

CD101 antigen

Synonyms

Igsf2, LOC381460

MMRRC Submission

038613-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0411 (G1)

Quality Score

163

Status

Not validated

Chromosome

Chromosomal Location

100993529-101029556 bp(-) (GRCm38)

Type of Mutation

splice site (46 bp from exon)

DNA Base Change (assembly)

A to T at 101018527 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000126027 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000147399] [ENSMUST00000167086]

Predicted Effect

probably null
Transcript: ENSMUST00000147399

SMART Domains

Protein: ENSMUSP00000116643
Gene: ENSMUSG00000086564

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
IG	28	143	4.96e-8	SMART
IG	153	266	4.74e-5	SMART
IG_like	274	379	2.19e-1	SMART
IG	289	395	3.25e-3	SMART
IG	417	533	4.85e-11	SMART
IG	545	659	1.52e-3	SMART
IG	680	805	3.16e-1	SMART
IG_like	827	927	2.95e-1	SMART
IG	856	955	1.04e-1	SMART
transmembrane domain	971	993	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000167086

SMART Domains

Protein: ENSMUSP00000126027
Gene: ENSMUSG00000086564

Domain	Start	End	E-Value	Type
IG	24	139	4.96e-8	SMART
IG	149	262	4.74e-5	SMART
IG_like	270	375	2.19e-1	SMART
IG	285	391	3.25e-3	SMART
IG	413	529	4.85e-11	SMART
IG	541	655	1.52e-3	SMART
IG	676	801	3.16e-1	SMART
IG_like	823	923	2.95e-1	SMART
IG	852	951	1.04e-1	SMART
transmembrane domain	967	989	N/A	INTRINSIC

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.1%
20x: 95.0%

Validation Efficiency

97% (66/68)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Gr-1+ cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	A	G	5: 63,896,491		probably benign	Het
6030469F06Rik	A	T	12: 31,184,731		noncoding transcript	Het
Acad11	T	C	9: 104,116,296	F541L	probably damaging	Het
Acin1	G	T	14: 54,646,774	R92S	probably damaging	Het
Appl1	A	G	14: 26,940,256	S490P	probably benign	Het
Aqp9	C	A	9: 71,130,444	V184L	probably benign	Het
Arih1	A	T	9: 59,485,983	I122N	possibly damaging	Het
Bmi1	T	C	2: 18,683,172		probably benign	Het
Bmpr1a	G	A	14: 34,415,877	T391I	possibly damaging	Het
Cacna1s	A	G	1: 136,113,303	K1256E	probably damaging	Het
Cacng3	C	T	7: 122,768,572	P225L	probably damaging	Het
Cd55	A	G	1: 130,462,557		probably benign	Het
Cenpe	T	C	3: 135,222,255	I258T	probably damaging	Het
Cma2	A	G	14: 55,973,678		probably benign	Het
Ddost	T	A	4: 138,309,653	S176T	probably benign	Het
Ddx19b	A	T	8: 111,023,964		probably null	Het
Dmxl2	A	G	9: 54,378,939	I2681T	probably damaging	Het
Ern1	C	T	11: 106,398,586	E964K	probably benign	Het
Galntl5	C	T	5: 25,220,174	R430C	probably benign	Het
Gga3	A	G	11: 115,587,433	L511P	probably damaging	Het
Gm7271	G	T	5: 76,500,487	V47L	possibly damaging	Het
Gria2	C	T	3: 80,710,858		probably benign	Het
Hmbs	A	T	9: 44,341,652	L28*	probably null	Het
Iffo2	A	G	4: 139,603,221	E220G	probably damaging	Het
Ifi30	A	G	8: 70,764,918		probably benign	Het
Irf2	T	A	8: 46,846,061	C297S	probably benign	Het
Izumo4	T	C	10: 80,703,084	Y94H	probably damaging	Het
Klhdc9	A	G	1: 171,359,785	V215A	probably benign	Het
Kmt2a	T	C	9: 44,819,964		probably benign	Het
Kmt2c	A	T	5: 25,375,957	C513S	probably damaging	Het
Lyg1	A	T	1: 37,949,896	M81K	possibly damaging	Het
Maip1	T	G	1: 57,415,693	W279G	probably damaging	Het
Myo7a	T	C	7: 98,071,937	T1263A	probably benign	Het
Naa15	T	A	3: 51,465,639	I701N	possibly damaging	Het
Ncoa3	A	G	2: 166,068,543	N1292S	probably benign	Het
Necab2	T	A	8: 119,454,240		probably benign	Het
Nfatc1	T	A	18: 80,698,042	I234F	possibly damaging	Het
Olfm1	G	A	2: 28,208,211	R95K	possibly damaging	Het
Olfr1118	A	G	2: 87,309,058	T90A	probably benign	Het
Olfr1329	A	T	4: 118,916,626	N280K	possibly damaging	Het
Otoa	T	C	7: 121,156,527		probably null	Het
Padi4	GCTGCGTACCTCCAC	GC	4: 140,748,449		probably benign	Het
Pard6g	A	G	18: 80,117,122	D150G	probably damaging	Het
Pax5	A	G	4: 44,609,783	L215S	probably damaging	Het
Pja2	A	T	17: 64,287,521		probably benign	Het
Plk4	T	A	3: 40,811,219		probably benign	Het
Polr1a	A	T	6: 71,978,421	H1687L	possibly damaging	Het
Ptcd2	G	A	13: 99,343,391	L41F	probably damaging	Het
Ropn1	T	A	16: 34,669,964	S62T	probably benign	Het
Setd1a	T	C	7: 127,796,051		probably benign	Het
Setdb1	T	C	3: 95,327,686	D902G	probably damaging	Het
Sik3	T	A	9: 46,208,770	L719Q	probably damaging	Het
Slc36a1	G	T	11: 55,232,507	V433F	probably benign	Het
Slc6a3	T	C	13: 73,557,050	V220A	possibly damaging	Het
Slc6a5	A	T	7: 49,911,791	R24W	probably damaging	Het
Smox	G	T	2: 131,520,644	R281L	probably benign	Het
Sulf2	G	T	2: 166,093,516	H226N	probably damaging	Het
Syne2	C	T	12: 76,059,584		probably null	Het
Tenm3	C	T	8: 48,287,791	S1210N	possibly damaging	Het
Tns1	A	T	1: 73,925,761	V1237E	probably damaging	Het
Trf	C	T	9: 103,217,501	V92M	probably damaging	Het
Ttn	A	G	2: 76,709,373	V34423A	possibly damaging	Het
Vmn2r118	A	G	17: 55,611,021		probably benign	Het
Vmn2r19	A	G	6: 123,309,744	Y112C	probably damaging	Het
Wdr66	C	T	5: 123,290,054	T538M	probably damaging	Het
Zfp326	G	T	5: 105,878,775	A15S	possibly damaging	Het

Other mutations in Cd101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00958:Cd101	APN	3	101003702	missense	probably damaging	1.00
IGL01443:Cd101	APN	3	101003571	missense	probably benign
IGL02000:Cd101	APN	3	101012082	missense	probably benign	0.11
IGL02178:Cd101	APN	3	100993766	missense	probably damaging	1.00
IGL02224:Cd101	APN	3	101017002	missense	probably benign
IGL02450:Cd101	APN	3	100993738	missense	probably damaging	0.99
IGL02502:Cd101	APN	3	101011825	missense	probably damaging	0.99
IGL02536:Cd101	APN	3	101003597	missense	probably damaging	1.00
IGL02749:Cd101	APN	3	101020399	missense	probably damaging	1.00
IGL02818:Cd101	APN	3	101011929	missense	probably damaging	1.00
IGL02829:Cd101	APN	3	101018565	splice site	probably benign
IGL02902:Cd101	APN	3	101018994	splice site	probably benign
tax_day	UTSW	3	101003705	missense	possibly damaging	0.86
R0069:Cd101	UTSW	3	101008217	missense	probably benign	0.08
R0069:Cd101	UTSW	3	101008217	missense	probably benign	0.08
R0486:Cd101	UTSW	3	101008092	missense	possibly damaging	0.94
R0556:Cd101	UTSW	3	101020654	missense	probably damaging	1.00
R0726:Cd101	UTSW	3	101020622	missense	possibly damaging	0.95
R0966:Cd101	UTSW	3	101008222	missense	probably benign	0.13
R1344:Cd101	UTSW	3	101018775	nonsense	probably null
R1418:Cd101	UTSW	3	101018775	nonsense	probably null
R1547:Cd101	UTSW	3	101018951	missense	possibly damaging	0.94
R1551:Cd101	UTSW	3	101012013	missense	probably damaging	0.99
R1845:Cd101	UTSW	3	101029448	splice site	probably null
R1919:Cd101	UTSW	3	101018917	missense	probably damaging	1.00
R1976:Cd101	UTSW	3	101008061	missense	probably damaging	0.96
R2260:Cd101	UTSW	3	101016945	missense	possibly damaging	0.82
R2679:Cd101	UTSW	3	100993763	missense	probably benign	0.00
R2873:Cd101	UTSW	3	101003848	missense	probably benign	0.00
R3606:Cd101	UTSW	3	101020597	missense	probably damaging	1.00
R4201:Cd101	UTSW	3	101018685	missense	probably damaging	1.00
R4202:Cd101	UTSW	3	101018685	missense	probably damaging	1.00
R4205:Cd101	UTSW	3	101018685	missense	probably damaging	1.00
R4349:Cd101	UTSW	3	101013314	missense	possibly damaging	0.93
R4574:Cd101	UTSW	3	101013153	missense	probably benign	0.02
R4601:Cd101	UTSW	3	100993888	missense	possibly damaging	0.84
R4820:Cd101	UTSW	3	101022155	missense	probably benign	0.01
R4910:Cd101	UTSW	3	100993889	missense	probably benign	0.13
R5014:Cd101	UTSW	3	101003823	missense	probably damaging	0.99
R5081:Cd101	UTSW	3	101003705	missense	possibly damaging	0.86
R5396:Cd101	UTSW	3	101018810	missense	probably damaging	1.00
R5425:Cd101	UTSW	3	101018686	missense	probably damaging	1.00
R6193:Cd101	UTSW	3	101020462	missense	probably damaging	1.00
R6210:Cd101	UTSW	3	101018643	missense	probably damaging	1.00
R6732:Cd101	UTSW	3	101008199	missense	probably benign	0.01
R6830:Cd101	UTSW	3	100993696	missense	probably benign	0.12
R6897:Cd101	UTSW	3	101013060	missense	probably damaging	1.00
R6940:Cd101	UTSW	3	101003702	missense	probably damaging	1.00
R7335:Cd101	UTSW	3	101018729	missense	probably benign	0.01
R7565:Cd101	UTSW	3	101018792	missense	probably benign	0.00
R7880:Cd101	UTSW	3	101007866	missense	probably benign	0.00
R8121:Cd101	UTSW	3	101020582	missense	probably damaging	1.00
R8233:Cd101	UTSW	3	100993673	missense	unknown
X0018:Cd101	UTSW	3	101018632	missense	possibly damaging	0.95
X0023:Cd101	UTSW	3	101018855	missense	probably benign
X0058:Cd101	UTSW	3	101020421	missense	probably damaging	1.00
Z1177:Cd101	UTSW	3	101011916	missense	probably benign	0.03
Z1177:Cd101	UTSW	3	101017140	missense	probably benign	0.02

Predicted Primers

Posted On

2015-02-04