Incidental Mutation 'R0524:Ppp1cc'
ID 261910
Institutional Source Beutler Lab
Gene Symbol Ppp1cc
Ensembl Gene ENSMUSG00000004455
Gene Name protein phosphatase 1 catalytic subunit gamma
Synonyms PP1, PP1C gamma, PP1C gamma 2, PP1C gamma 1
MMRRC Submission 038717-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0524 (G1)
Quality Score 110
Status Not validated
Chromosome 5
Chromosomal Location 122296341-122313336 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 122310833 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 142 (R142*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086294] [ENSMUST00000102528] [ENSMUST00000128309] [ENSMUST00000132555]
AlphaFold P63087
Predicted Effect probably null
Transcript: ENSMUST00000086294
AA Change: R188*
SMART Domains Protein: ENSMUSP00000083474
Gene: ENSMUSG00000004455
AA Change: R188*

DomainStartEndE-ValueType
PP2Ac 30 300 6.44e-164 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102528
AA Change: R188*
SMART Domains Protein: ENSMUSP00000099587
Gene: ENSMUSG00000004455
AA Change: R188*

DomainStartEndE-ValueType
PP2Ac 30 300 6.44e-164 SMART
Predicted Effect probably null
Transcript: ENSMUST00000128309
AA Change: R188*
SMART Domains Protein: ENSMUSP00000142415
Gene: ENSMUSG00000004455
AA Change: R188*

DomainStartEndE-ValueType
PP2Ac 30 272 1.5e-116 SMART
Predicted Effect probably null
Transcript: ENSMUST00000132555
AA Change: R188*
SMART Domains Protein: ENSMUSP00000143509
Gene: ENSMUSG00000004455
AA Change: R188*

DomainStartEndE-ValueType
PP2Ac 30 272 1.5e-116 SMART
Predicted Effect silent
Transcript: ENSMUST00000133568
Predicted Effect probably null
Transcript: ENSMUST00000134719
AA Change: R13*
Predicted Effect probably null
Transcript: ENSMUST00000151184
AA Change: R14*
Predicted Effect probably null
Transcript: ENSMUST00000197730
AA Change: R142*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135090
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199354
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142562
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.7%
  • 10x: 96.4%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation exhibit male infertility due to severely impaired spermiogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd3 CGAGGAGGAGGAGGAGGA CGAGGAGGAGGAGGA 1: 180,574,624 (GRCm39) probably benign Het
Adamts16 T C 13: 70,949,013 (GRCm39) E216G probably benign Het
Aoc3 C A 11: 101,228,337 (GRCm39) P715T probably damaging Het
Bnipl T C 3: 95,157,140 (GRCm39) D33G probably benign Het
Celsr2 T C 3: 108,308,903 (GRCm39) H1701R probably damaging Het
Clca3b T A 3: 144,531,082 (GRCm39) H756L probably benign Het
Clca4a A G 3: 144,675,154 (GRCm39) W159R probably damaging Het
Ddx49 A T 8: 70,749,574 (GRCm39) I252N probably damaging Het
Duox2 T C 2: 122,112,317 (GRCm39) T1290A possibly damaging Het
Fam111a T A 19: 12,565,412 (GRCm39) I431K probably damaging Het
Fam135b A T 15: 71,334,133 (GRCm39) D1020E probably benign Het
Flii A G 11: 60,610,887 (GRCm39) V514A probably damaging Het
Frmpd1 A G 4: 45,283,774 (GRCm39) D865G probably benign Het
Frmpd1 G A 4: 45,256,902 (GRCm39) V157M probably damaging Het
Gsr G A 8: 34,159,208 (GRCm39) probably null Het
H1f11-ps T A 19: 47,158,933 (GRCm39) K214M unknown Het
Hps3 A T 3: 20,066,940 (GRCm39) V542E probably damaging Het
Kcnj5 A G 9: 32,234,270 (GRCm39) I15T probably benign Het
Kif2b T C 11: 91,466,550 (GRCm39) R578G probably benign Het
Lamb2 A G 9: 108,361,571 (GRCm39) R676G possibly damaging Het
Mrpl40 A G 16: 18,692,302 (GRCm39) F94S possibly damaging Het
Myo7b C T 18: 32,146,477 (GRCm39) V103M possibly damaging Het
Nmt2 T A 2: 3,306,474 (GRCm39) W69R probably benign Het
Nsd3 C A 8: 26,190,605 (GRCm39) Q1130K possibly damaging Het
Olfml1 T C 7: 107,189,384 (GRCm39) S150P probably damaging Het
Or2g1 A T 17: 38,106,496 (GRCm39) K54* probably null Het
Or5b116 A G 19: 13,423,228 (GRCm39) N284S probably damaging Het
Pask A T 1: 93,238,556 (GRCm39) W1310R probably damaging Het
Pcdh18 T C 3: 49,710,091 (GRCm39) Q408R probably damaging Het
Pfkm A G 15: 98,029,488 (GRCm39) I700V probably benign Het
Pias1 A G 9: 62,859,460 (GRCm39) V16A probably damaging Het
Pnpla8 C T 12: 44,330,401 (GRCm39) Q318* probably null Het
Pygl T A 12: 70,254,498 (GRCm39) N149I probably damaging Het
Rapgef6 T A 11: 54,581,110 (GRCm39) S1285T probably benign Het
Rdh13 A C 7: 4,447,296 (GRCm39) C10W probably damaging Het
Rgr A T 14: 36,760,252 (GRCm39) C273S probably benign Het
Ripk4 G T 16: 97,556,487 (GRCm39) Y22* probably null Het
Slc34a2 G A 5: 53,222,215 (GRCm39) W302* probably null Het
Smarce1 G A 11: 99,104,888 (GRCm39) T263M probably damaging Het
Sypl1 C T 12: 33,017,564 (GRCm39) P94L possibly damaging Het
Tet3 A G 6: 83,356,924 (GRCm39) I878T probably damaging Het
Tmem232 A G 17: 65,792,937 (GRCm39) S87P probably damaging Het
Tmem260 A G 14: 48,709,935 (GRCm39) T163A probably benign Het
Ttn T C 2: 76,555,796 (GRCm39) Y30403C probably damaging Het
Ubash3b A T 9: 40,927,904 (GRCm39) M468K probably benign Het
Ulk4 A G 9: 121,081,717 (GRCm39) probably null Het
Vmn1r72 A G 7: 11,403,719 (GRCm39) F243S probably benign Het
Wrap73 A G 4: 154,229,764 (GRCm39) Y45C probably damaging Het
Zfp704 T C 3: 9,674,424 (GRCm39) D119G unknown Het
Zfp719 A G 7: 43,238,677 (GRCm39) probably null Het
Other mutations in Ppp1cc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02747:Ppp1cc APN 5 122,312,136 (GRCm39) missense probably benign 0.02
R1223:Ppp1cc UTSW 5 122,306,277 (GRCm39) missense probably damaging 1.00
R2926:Ppp1cc UTSW 5 122,312,151 (GRCm39) missense probably benign
R2999:Ppp1cc UTSW 5 122,312,151 (GRCm39) missense probably benign
R4133:Ppp1cc UTSW 5 122,306,289 (GRCm39) missense probably benign 0.08
R8031:Ppp1cc UTSW 5 122,312,151 (GRCm39) missense probably benign
R9063:Ppp1cc UTSW 5 122,306,279 (GRCm39) missense probably benign
Z1088:Ppp1cc UTSW 5 122,310,816 (GRCm39) missense possibly damaging 0.91
Predicted Primers
Posted On 2015-02-04